Annotations: 1XM3

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1xm3a_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	ThiG-like	ThiG-like	Thiazole biosynthesis protein ThiG	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
B	d1xm3b_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	ThiG-like	ThiG-like	Thiazole biosynthesis protein ThiG	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
C	d1xm3c_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	ThiG-like	ThiG-like	Thiazole biosynthesis protein ThiG	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
D	d1xm3d_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	ThiG-like	ThiG-like	Thiazole biosynthesis protein ThiG	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ThiG-like	8043996	3000645	SCOP2B (2022-06-29)
B	SCOP2 Family	ThiG-like	8031618	4001971	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	ThiG-like	8043996	3000645	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	ThiG-like	8043996	3000645	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ThiG-like	8043996	3000645	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ThiG	e1xm3A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: ThiG	ECOD (1.6)
B	ThiG	e1xm3B1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: ThiG	ECOD (1.6)
C	ThiG	e1xm3C1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: ThiG	ECOD (1.6)
D	ThiG	e1xm3D1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: ThiG	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
C	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
D	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF05690	Thiazole biosynthesis protein ThiG (ThiG)	Thiazole biosynthesis protein ThiG	This family consists of several bacterial thiazole biosynthesis protein G sequences. ThiG , together with ThiF and ThiH, is proposed to be involved in the synthesis of 4-methyl-5-(b-hydroxyethyl)thiazole (THZ) which is an intermediate in the thiazole ...	This family consists of several bacterial thiazole biosynthesis protein G sequences. ThiG , together with ThiF and ThiH, is proposed to be involved in the synthesis of 4-methyl-5-(b-hydroxyethyl)thiazole (THZ) which is an intermediate in the thiazole production pathway [1]. This family also includes triosephosphate isomerase and pyridoxal 5'-phosphate synthase subunit PdxS.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Thiazole biosynthesis protein thiG	thiazole synthase activity sulfurtransferase activity transferase activity, transferring sulphur-containing groups transferase activity catalytic activity	cellular biosynthetic process organonitrogen compound biosynthetic process thiamine-containing compound metabolic process vitamin biosynthetic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process thiamine diphosphate metabolic process small molecule metabolic process sulfur compound metabolic process pyrimidine-containing compound biosynthetic process water-soluble vitamin metabolic process phosphorus metabolic process pyrimidine-containing compound metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process thiamine-containing compound metabolic process vitamin biosynthetic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process thiamine diphosphate metabolic process small molecule metabolic process sulfur compound metabolic process pyrimidine-containing compound biosynthetic process water-soluble vitamin metabolic process phosphorus metabolic process pyrimidine-containing compound metabolic process organonitrogen compound metabolic process water-soluble vitamin biosynthetic process small molecule biosynthetic process cellular metabolic process vitamin metabolic process organic cyclic compound metabolic process sulfur compound biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process thiamine diphosphate biosynthetic process thiamine-containing compound biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A, B, C, D	IPR033983	Thiazole synthase ThiG	Domain
A, B, C, D	IPR008867	Thiazole synthase	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.