1XK4

Crystal structure of human calprotectin(S100A8/S100A9)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
L	d1xk4l_	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1xk4c_	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1xk4d_	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d1xk4g_	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d1xk4h_	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d1xk4k_	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1xk4a1	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1xk4b_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1xk4e_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1xk4f_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d1xk4i_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d1xk4j_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
L	SCOP2B Superfamily	EF-hand	8033752	3001983	SCOP2B (2022-06-29)
C	SCOP2 Family	S100 proteins	8021372	4000919	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	EF-hand	8033752	3001983	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	EF-hand	8033752	3001983	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	EF-hand	8033752	3001983	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	EF-hand	8033752	3001983	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	EF-hand	8033752	3001983	SCOP2B (2022-06-29)
A	SCOP2 Family	S100 proteins	8021367	4000919	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	EF-hand	8033747	3001983	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	EF-hand	8033747	3001983	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	EF-hand	8033747	3001983	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	EF-hand	8033747	3001983	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	EF-hand	8033747	3001983	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	EF-hand	8033747	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
L	S_100	e1xk4L1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
C	S_100	e1xk4C1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
D	S_100	e1xk4D1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
G	S_100	e1xk4G1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
H	S_100	e1xk4H1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
K	S_100	e1xk4K1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
A	S_100	e1xk4A1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
B	S_100	e1xk4B1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
E	S_100	e1xk4E1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
F	S_100	e1xk4F1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
I	S_100	e1xk4I1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
J	S_100	e1xk4J1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
L	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
D	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
G	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
H	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
K	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
E	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
F	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
I	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
J	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, D, G, H, K C, D, G, H, K, L	PF01023	S-100/ICaBP type calcium binding domain (S_100)	S-100/ICaBP type calcium binding domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	Domain
A, B, E, F, I A, B, E, F, I, J	PF01023	S-100/ICaBP type calcium binding domain (S_100)	S-100/ICaBP type calcium binding domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, D, G, H, K C, D, G, H, K, L	Calgranulin B	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding cation binding ion binding calcium ion binding metal ion binding small molecule binding antioxidant activity Toll-like receptor 4 binding signaling receptor binding Toll-like receptor binding cytoskeletal protein binding microtubule binding protein binding binding tubulin binding cation binding ion binding calcium ion binding metal ion binding small molecule binding antioxidant activity Toll-like receptor 4 binding signaling receptor binding Toll-like receptor binding fatty acid binding icosanoid binding organic acid binding arachidonic acid binding long-chain fatty acid binding icosatetraenoic acid binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding RAGE receptor binding calcium-dependent protein binding transition metal ion binding zinc ion binding	regulation of immune effector process multicellular organismal process regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus regulation of respiratory burst involved in inflammatory response response to stress regulation of response to stress innate immune response regulation of immune system process regulation of multicellular organismal process regulation of immune effector process multicellular organismal process regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus regulation of respiratory burst involved in inflammatory response response to stress regulation of response to stress innate immune response regulation of immune system process regulation of multicellular organismal process response to external biotic stimulus regulation of respiratory burst production of molecular mediator involved in inflammatory response regulation of biological process respiratory burst involved in defense response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of inflammatory response immune effector process respiratory burst regulation of response to stimulus immune system process defense response to other organism respiratory burst involved in inflammatory response regulation of immune response metabolic process inflammatory response regulation of metabolic process positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response positive regulation of defense response modulation of process of another organism cellular catabolic process catabolic process cellular metabolic process autophagy cellular process process utilizing autophagic mechanism epithelium migration tissue migration endothelial cell migration ameboidal-type cell migration epithelial cell migration cell migration cell motility cell chemotaxis cellular response to stimulus chemotaxis neutrophil chemotaxis neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis granulocyte chemotaxis response to chemical myeloid leukocyte migration leukocyte chemotaxis locomotion apoptotic process cell death programmed cell death signaling cell-cell signaling cell communication defense response to bacterium response to bacterium leukocyte migration involved in inflammatory response positive regulation of response to biotic stimulus regulation of cellular process pattern recognition receptor signaling pathway toll-like receptor signaling pathway regulation of signal transduction immune response-activating signaling pathway positive regulation of immune response signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of pattern recognition receptor signaling pathway activation of innate immune response regulation of toll-like receptor signaling pathway activation of immune response immune response-regulating signaling pathway regulation of signaling positive regulation of innate immune response regulation of cell communication developmental process cellular developmental process astrocyte differentiation cell development nervous system development glial cell development multicellular organism development neurogenesis astrocyte development central nervous system development gliogenesis glial cell differentiation cell differentiation anatomical structure development system development autocrine signaling regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cell projection organization neuron projection development cellular component organization neuron differentiation positive regulation of neuron projection development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process plasma membrane bounded cell projection organization regulation of cell projection organization generation of neurons neuron development regulation of plasma membrane bounded cell projection organization neutrophil aggregation cell adhesion cell-cell adhesion leukocyte cell-cell adhesion leukocyte aggregation positive regulation of DNA-binding transcription factor activity cellular biosynthetic process positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process positive regulation of cell communication positive regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction positive regulation of apoptotic signaling pathway regulation of intracellular signal transduction intrinsic apoptotic signaling pathway positive regulation of programmed cell death regulation of apoptotic process positive regulation of intracellular signal transduction positive regulation of apoptotic process apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling regulation of growth growth positive regulation of cell growth regulation of cell growth cell growth positive regulation of growth cellular localization inorganic ion homeostasis homeostatic process sequestering of metal ion maintenance of location in cell maintenance of location localization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis intracellular zinc ion homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis sequestering of zinc ion intracellular monoatomic ion homeostasis regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process protein metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis chronic inflammatory response regulation of cytoskeleton organization regulation of organelle organization organelle organization cytoskeleton organization peptidyl-cysteine modification peptidyl-cysteine S-nitrosylation peptidyl-cysteine S-trans-nitrosylation macromolecule modification peptidyl-amino acid modification protein modification process protein nitrosylation humoral immune response antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide defense response to fungus response to fungus plasma membrane organization integrin biosynthetic process endomembrane system organization membrane organization regulation of integrin biosynthetic process response to organic substance response to lipid response to oxygen-containing compound response to lipopolysaccharide response to molecule of bacterial origin	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol protein-containing complex transmembrane transporter complex S100A9 complex membrane membrane protein complex transporter complex intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle plasma membrane calprotectin complex vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen cytoplasmic vesicle organelle lumen secretory granule secretory vesicle nucleus
A, B, E, F, I A, B, E, F, I, J	Calgranulin A	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding cation binding ion binding calcium ion binding metal ion binding small molecule binding Toll-like receptor 4 binding signaling receptor binding Toll-like receptor binding fatty acid binding cytoskeletal protein binding microtubule binding protein binding binding tubulin binding cation binding ion binding calcium ion binding metal ion binding small molecule binding Toll-like receptor 4 binding signaling receptor binding Toll-like receptor binding fatty acid binding icosanoid binding organic acid binding arachidonic acid binding long-chain fatty acid binding icosatetraenoic acid binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding RAGE receptor binding calcium-dependent protein binding transition metal ion binding zinc ion binding	regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response cellular catabolic process catabolic process cellular metabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism cell chemotaxis cellular response to stimulus chemotaxis neutrophil chemotaxis neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis immune system process granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion apoptotic process cell death programmed cell death biological process involved in interspecies interaction between organisms immune response response to other organism defense response to symbiont response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus defense response to bacterium response to bacterium leukocyte migration involved in inflammatory response positive regulation of response to biotic stimulus regulation of cellular process pattern recognition receptor signaling pathway toll-like receptor signaling pathway regulation of signal transduction cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of innate immune response regulation of pattern recognition receptor signaling pathway activation of innate immune response regulation of immune response regulation of toll-like receptor signaling pathway activation of immune response regulation of response to biotic stimulus signaling immune response-regulating signaling pathway regulation of signaling positive regulation of innate immune response regulation of cell communication developmental process multicellular organismal process cellular developmental process astrocyte differentiation cell development nervous system development glial cell development multicellular organism development neurogenesis astrocyte development central nervous system development gliogenesis glial cell differentiation cell differentiation anatomical structure development system development cell-cell signaling autocrine signaling organonitrogen compound metabolic process peptidyl-cysteine modification primary metabolic process peptidyl-cysteine S-nitrosylation organic substance metabolic process macromolecule modification peptidyl-amino acid modification protein metabolic process macromolecule metabolic process protein modification process protein nitrosylation neutrophil aggregation cell adhesion cell-cell adhesion leukocyte cell-cell adhesion leukocyte aggregation peptide transport peptide secretion localization nitrogen compound transport secretion transport amide transport organic substance transport establishment of localization response to metal ion response to zinc ion response to inorganic substance positive regulation of DNA-binding transcription factor activity cellular biosynthetic process positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of cell communication positive regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction positive regulation of apoptotic signaling pathway regulation of intracellular signal transduction intrinsic apoptotic signaling pathway positive regulation of cellular process positive regulation of programmed cell death regulation of apoptotic process positive regulation of intracellular signal transduction positive regulation of apoptotic process apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling regulation of growth regulation of cellular component organization growth positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular component organization or biogenesis cellular localization inorganic ion homeostasis homeostatic process sequestering of metal ion maintenance of location in cell maintenance of location cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis intracellular zinc ion homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis sequestering of zinc ion intracellular monoatomic ion homeostasis regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis chronic inflammatory response positive regulation of peptide secretion regulation of localization regulation of peptide secretion regulation of transport regulation of peptide transport regulation of secretion positive regulation of secretion positive regulation of transport regulation of cytoskeleton organization regulation of organelle organization organelle organization cytoskeleton organization response to organic substance response to alcohol response to oxygen-containing compound response to ethanol defense response to fungus response to fungus response to lipid response to lipopolysaccharide response to molecule of bacterial origin	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle intermediate filament cytoskeleton plasma membrane membrane calprotectin complex protein-containing complex vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen cytoplasmic vesicle organelle lumen secretory granule secretory vesicle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, D, G, H, K C, D, G, H, K, L	IPR001751	S100/Calcium binding protein 7/8-like, conserved site	Conserved Site
C, D, G, H, K C, D, G, H, K, L	IPR002048	EF-hand domain	Domain
C, D, G, H, K C, D, G, H, K, L	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
C, D, G, H, K C, D, G, H, K, L	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain	Domain
C, D, G, H, K C, D, G, H, K, L	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B, E, F, I A, B, E, F, I, J	IPR001751	S100/Calcium binding protein 7/8-like, conserved site	Conserved Site
A, B, E, F, I A, B, E, F, I, J	IPR002048	EF-hand domain	Domain
A, B, E, F, I A, B, E, F, I, J	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B, E, F, I A, B, E, F, I, J	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain	Domain
A, B, E, F, I A, B, E, F, I, J	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C, D, G, H, K C, D, G, H, K, L	Pharos: P06702	malignant colon neoplasm adult acute respiratory distress syndrome keloid Liver Cirrhosis, Experimental nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sinusitis B-cell chronic lymphocytic leukemia colonic neoplasm cystic fibrosis gastric carcinoma lung cancer MALT lymphoma osteosarcoma psoriasis malignant colon neoplasm adult acute respiratory distress syndrome keloid Liver Cirrhosis, Experimental nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sinusitis B-cell chronic lymphocytic leukemia colonic neoplasm cystic fibrosis gastric carcinoma lung cancer MALT lymphoma osteosarcoma psoriasis tuberculosis asthma benign colon neoplasm Crohn disease dermatomyositis glioblastoma large cell medulloblastoma lung carcinoma myopathy ovarian cancer schizophrenia ulcerative colitis atopic eczema breast carcinoma cutaneous lupus erythematosus esophageal adenocarcinoma interstitial cystitis
A, B, E, F, I A, B, E, F, I, J	Pharos: P05109	acute myeloid leukemia keloid atopic eczema contact dermatitis gastric cancer interstitial cystitis large cell medulloblastoma lung carcinoma Mammary Carcinoma, Animal adrenal cortex adenoma myopathy atypical teratoid rhabdoid tumor osteosarcoma breast carcinoma pancreatic intraductal papillary-mucinous carcinoma acute myeloid leukemia keloid atopic eczema contact dermatitis gastric cancer interstitial cystitis large cell medulloblastoma lung carcinoma Mammary Carcinoma, Animal adrenal cortex adenoma myopathy atypical teratoid rhabdoid tumor osteosarcoma breast carcinoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer tuberculosis dermatitis, atopic gastritis invasive ductal breast carcinoma lung adenocarcinoma lymphoplasmacytic lymphoma mammary neoplasms, animal nasopharyngeal carcinoma B-cell chronic lymphocytic leukemia ovarian cancer congestive heart failure pancreatic intraductal papillary-mucinous neoplasm psoriasis Crohn disease type 2 diabetes mellitus dermatomyositis esophageal adenocarcinoma glioblastoma lung cancer MALT lymphoma medulloblastoma non-small cell lung carcinoma breast cancer pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome cutaneous lupus erythematosus ulcerative colitis duodenal ulcer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.