Annotations: 1XI5

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1xi5a_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1xi5b_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d1xi5c_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d1xi5d_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
E	d1xi5e_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
F	d1xi5f_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
G	d1xi5g_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
H	d1xi5h_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
I	d1xi5i_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
J	d1xi5j_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
K	d1xi5k_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
L	d1xi5l_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
M	d1xi5m_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
N	d1xi5n_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
O	d1xi5o_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
P	d1xi5p_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
Q	d1xi5q_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
R	d1xi5r_	Low resolution protein structures	clathrin assemblies	clathrin assemblies	clathrin assemblies	Clathrin D6 coat	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Chaperone J-domain	8033756	3000721	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Chaperone J-domain	8033756	3000721	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Chaperone J-domain	8033756	3000721	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Chaperone J-domain	8033756	3000721	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Chaperone J-domain	8033756	3000721	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Chaperone J-domain	8033756	3000721	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Chaperone J-domain	8033756	3000721	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Chaperone J-domain	8033756	3000721	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Chaperone J-domain	8033756	3000721	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Clathrin_propel	e1xi5A2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
A	Clathrin_H_link	e1xi5A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
B	Clathrin_propel	e1xi5B2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
B	Clathrin_H_link	e1xi5B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
C	Clathrin_propel	e1xi5C2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
C	Clathrin_H_link	e1xi5C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
D	Clathrin_propel	e1xi5D2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
D	Clathrin_H_link	e1xi5D1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
E	Clathrin_propel	e1xi5E2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
E	Clathrin_H_link	e1xi5E1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
F	Clathrin_propel	e1xi5F2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
F	Clathrin_H_link	e1xi5F1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
G	Clathrin_propel	e1xi5G2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
G	Clathrin_H_link	e1xi5G1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
H	Clathrin_propel	e1xi5H2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
H	Clathrin_H_link	e1xi5H1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
I	Clathrin_propel	e1xi5I2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
I	Clathrin_H_link	e1xi5I1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
J	DnaJ	e1xi5J1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
K	DnaJ	e1xi5K1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
L	DnaJ	e1xi5L1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
M	DnaJ	e1xi5M1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
N	DnaJ	e1xi5N1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
O	DnaJ	e1xi5O1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
P	DnaJ	e1xi5P1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
Q	DnaJ	e1xi5Q1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
R	DnaJ	e1xi5R1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I	PF09268	Clathrin, heavy-chain linker (Clathrin-link)	Clathrin, heavy-chain linker	-	Repeat
A, B, C, D, E A, B, C, D, E, F, G, H, I	PF00637	Region in Clathrin and VPS (Clathrin)	Region in Clathrin and VPS	-	Repeat
A, B, C, D, E A, B, C, D, E, F, G, H, I	PF13838	Clathrin-H-link (Clathrin_H_link)	Clathrin-H-link	-	Repeat
A, B, C, D, E A, B, C, D, E, F, G, H, I	PF01394	Clathrin propeller repeat (Clathrin_propel)	Clathrin propeller repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I	Clathrin heavy chain	clathrin binding protein binding binding clathrin light chain binding protein domain specific binding arrestin family protein binding structural molecule activity disordered domain specific binding identical protein binding	cellular process cell cycle mitotic cell cycle cell division cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism cellular component disassembly clathrin coat disassembly transport protein-containing complex organization cellular process cell cycle mitotic cell cycle cell division cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism cellular component disassembly clathrin coat disassembly transport protein-containing complex organization protein-containing complex disassembly establishment of localization vesicle-mediated transport vesicle uncoating cellular component organization localization cellular component organization or biogenesis protein depolymerization protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport clathrin coat assembly cellular component biogenesis cellular component assembly protein-containing complex assembly regulation of cellular process negative regulation of biological process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance biosynthetic process glycosaminoglycan biosynthetic process negative regulation of carbohydrate metabolic process regulation of biological process negative regulation of metabolic process carbohydrate biosynthetic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process hyaluronan biosynthetic process biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process mucopolysaccharide metabolic process cellular biosynthetic process glycosaminoglycan metabolic process regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process negative regulation of hyaluronan biosynthetic process organic substance metabolic process hyaluronan metabolic process polysaccharide metabolic process negative regulation of cellular process regulation of carbohydrate metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process organonitrogen compound metabolic process polysaccharide biosynthetic process biological regulation regulation of macromolecule metabolic process macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan metabolic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process import into cell receptor-mediated endocytosis endocytosis	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex coated membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit clathrin coat of coated pit pigment granule intracellular vesicle melanosome cytoplasmic vesicle vesicle clathrin complex cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle clathrin-coated endocytic vesicle clathrin-coated vesicle coated vesicle endocytic vesicle vesicle coat transport vesicle membrane clathrin coat of trans-Golgi network vesicle bounding membrane of organelle trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle vesicle membrane clathrin vesicle coat Golgi-associated vesicle clathrin-coated vesicle membrane transport vesicle Golgi apparatus coated vesicle membrane cytoplasmic vesicle membrane Golgi-associated vesicle membrane organelle membrane
J, K, L, M, N J, K, L, M, N, O, P, Q, R	Auxilin J-domain	clathrin binding protein binding binding protein domain specific binding heat shock protein binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity clathrin heavy chain binding clathrin binding protein binding binding protein domain specific binding heat shock protein binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity clathrin heavy chain binding SH3 domain binding molecular adaptor activity	synaptic vesicle recycling localization cellular localization transport establishment of localization in cell synaptic vesicle cycle cellular process establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse cellular component disassembly clathrin coat disassembly protein-containing complex organization protein-containing complex disassembly synaptic vesicle recycling localization cellular localization transport establishment of localization in cell synaptic vesicle cycle cellular process establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse cellular component disassembly clathrin coat disassembly protein-containing complex organization protein-containing complex disassembly vesicle uncoating cellular component organization cellular component organization or biogenesis protein depolymerization import into cell clathrin-dependent endocytosis receptor-mediated endocytosis endocytosis intracellular transport synaptic vesicle uncoating presynaptic endocytosis synaptic vesicle endocytosis regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation regulation of clathrin coat assembly regulation of cellular component biogenesis clathrin coat assembly cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly dephosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process	membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle clathrin-coated vesicle coated vesicle cytoplasm presynapse synapse membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle clathrin-coated vesicle coated vesicle cytoplasm presynapse synapse cell junction postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR016341	Clathrin, heavy chain	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR015348	Clathrin, heavy chain, linker, core motif	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR016025	Clathrin heavy chain, N-terminal	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat	Repeat
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR022365	Clathrin, heavy chain, propeller repeat	Repeat
J, K, L, M, N J, K, L, M, N, O, P, Q, R	IPR001623	DnaJ domain	Domain
J, K, L, M, N J, K, L, M, N, O, P, Q, R	IPR029023	Tensin-type phosphatase domain	Domain
J, K, L, M, N J, K, L, M, N, O, P, Q, R	IPR014020	Tensin phosphatase, C2 domain	Domain
J, K, L, M, N J, K, L, M, N, O, P, Q, R	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
J, K, L, M, N J, K, L, M, N, O, P, Q, R	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily
J, K, L, M, N J, K, L, M, N, O, P, Q, R	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
J, K, L, M, N J, K, L, M, N, O, P, Q, R	IPR035892	C2 domain superfamily	Homologous Superfamily