1X9Z

Crystal structure of the MutL C-terminal domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1x9za_	Alpha and beta proteins (a+b)	DNA mismatch repair protein MutL	DNA mismatch repair protein MutL	DNA mismatch repair protein MutL	DNA mismatch repair protein MutL	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1x9zb_	Alpha and beta proteins (a+b)	DNA mismatch repair protein MutL	DNA mismatch repair protein MutL	DNA mismatch repair protein MutL	DNA mismatch repair protein MutL	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DNA mismatch repair protein MutL	8031359	4003837	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DNA mismatch repair protein MutL	8043737	3001605	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	DNA mismatch repair protein MutL	8043737	3001605	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08676	e1x9zA2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: DNA mismatch repair protein MutL regulatory subdomain (From Topology)	T: DNA mismatch repair protein MutL regulatory subdomain	F: PF08676	ECOD (1.6)
A	F_UNCLASSIFIED	e1x9zA3	A: a+b two layers	X: DNA mismatch repair protein MutL dimerization subdomain (From Topology)	H: DNA mismatch repair protein MutL dimerization subdomain (From Topology)	T: DNA mismatch repair protein MutL dimerization subdomain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF08676	e1x9zB2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: DNA mismatch repair protein MutL regulatory subdomain (From Topology)	T: DNA mismatch repair protein MutL regulatory subdomain	F: PF08676	ECOD (1.6)
B	F_UNCLASSIFIED	e1x9zB1	A: a+b two layers	X: DNA mismatch repair protein MutL dimerization subdomain (From Topology)	H: DNA mismatch repair protein MutL dimerization subdomain (From Topology)	T: DNA mismatch repair protein MutL dimerization subdomain	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1540.20	Alpha Beta	2-Layer Sandwich	formyl-coa transferase, domain 3	MutL, C-terminal domain, dimerisation subdomain	CATH (4.3.0)
A	3.30.1370.100	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (4.3.0)
B	3.30.1540.20	Alpha Beta	2-Layer Sandwich	formyl-coa transferase, domain 3	MutL, C-terminal domain, dimerisation subdomain	CATH (4.3.0)
B	3.30.1370.100	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08676	MutL C terminal dimerisation domain (MutL_C)	MutL C terminal dimerisation domain	MutL and MutS are key components of the DNA repair machinery that corrects replication errors [1]. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The ...	MutL and MutS are key components of the DNA repair machinery that corrects replication errors [1]. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The N terminal region of MutL contains the ATPase domain and the C terminal is involved in dimerisation [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	DNA mismatch repair protein mutL	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding double-stranded DNA binding mismatched DNA binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding ATP-dependent activity, acting on DNA DNA damage sensor activity catalytic activity, acting on DNA small molecule sensor activity ATP-dependent DNA damage sensor activity catalytic activity, acting on a nucleic acid	cellular response to stimulus mismatch repair DNA-templated DNA replication response to stimulus DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication DNA replication organic substance metabolic process cellular response to stress DNA damage response cellular response to stimulus mismatch repair DNA-templated DNA replication response to stimulus DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication DNA replication organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair DNA geometric change DNA conformation change cellular component organization nucleotide-excision repair cellular component organization or biogenesis DNA duplex unwinding chromosome organization nucleotide-excision repair, DNA duplex unwinding organelle organization regulation of DNA recombination regulation of biological process DNA recombination biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA metabolic process	protein-containing complex catalytic complex DNA helicase complex single-stranded DNA-dependent ATP-dependent DNA helicase complex intracellular anatomical structure cellular anatomical entity mismatch repair complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR038973	DNA mismatch repair protein MutL/Mlh/Pms-like	Family
A, B	IPR037198	MutL, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR013507	DNA mismatch repair protein, S5 domain 2-like	Domain
A, B	IPR014790	MutL, C-terminal, dimerisation	Domain
A, B	IPR002099	DNA mismatch repair protein MutL/Mlh/PMS	Family
A, B	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B	IPR042121	MutL, C-terminal domain, regulatory subdomain	Homologous Superfamily
A, B	IPR042120	MutL, C-terminal domain, dimerisation subdomain	Homologous Superfamily
A, B	IPR014762	DNA mismatch repair, conserved site	Conserved Site
A, B	IPR020667	DNA mismatch repair protein, MutL	Family
A, B	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
A, B	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.