1X8M

X-ray structure of pectin degrading enzyme 5-keto 4-deoxyuronate isomerase from Escherichia coli

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1x8ma1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	KduI-like	5-keto-4-deoxyuronate isomerase KduI	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1x8ma2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1x8mb1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	KduI-like	5-keto-4-deoxyuronate isomerase KduI	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1x8mb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1x8mc1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	KduI-like	5-keto-4-deoxyuronate isomerase KduI	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1x8mc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1x8md1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	KduI-like	5-keto-4-deoxyuronate isomerase KduI	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1x8md2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d1x8me1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	KduI-like	5-keto-4-deoxyuronate isomerase KduI	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d1x8me2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d1x8mf1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	KduI-like	5-keto-4-deoxyuronate isomerase KduI	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d1x8mf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RmlC-like cupins	8033872	3001825	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RmlC-like cupins	8033872	3001825	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RmlC-like cupins	8033872	3001825	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RmlC-like cupins	8033872	3001825	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	RmlC-like cupins	8033872	3001825	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	RmlC-like cupins	8033872	3001825	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KduI_1	e1x8mA2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: KduI_1	ECOD (1.6)
B	KduI_1	e1x8mB2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: KduI_1	ECOD (1.6)
C	KduI_1	e1x8mC2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: KduI_1	ECOD (1.6)
D	KduI_1	e1x8mD2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: KduI_1	ECOD (1.6)
E	KduI_1	e1x8mE2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: KduI_1	ECOD (1.6)
F	KduI_1	e1x8mF2	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: KduI_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.520	Mainly Beta	Sandwich	Jelly Rolls	pectin degrading enzyme 5-keto 4- deoxyuronate isomerase, domain 1	CATH (4.3.0)
A	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
B	2.60.120.520	Mainly Beta	Sandwich	Jelly Rolls	pectin degrading enzyme 5-keto 4- deoxyuronate isomerase, domain 1	CATH (4.3.0)
B	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
C	2.60.120.520	Mainly Beta	Sandwich	Jelly Rolls	pectin degrading enzyme 5-keto 4- deoxyuronate isomerase, domain 1	CATH (4.3.0)
C	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
D	2.60.120.520	Mainly Beta	Sandwich	Jelly Rolls	pectin degrading enzyme 5-keto 4- deoxyuronate isomerase, domain 1	CATH (4.3.0)
D	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
E	2.60.120.520	Mainly Beta	Sandwich	Jelly Rolls	pectin degrading enzyme 5-keto 4- deoxyuronate isomerase, domain 1	CATH (4.3.0)
E	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
F	2.60.120.520	Mainly Beta	Sandwich	Jelly Rolls	pectin degrading enzyme 5-keto 4- deoxyuronate isomerase, domain 1	CATH (4.3.0)
F	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF04962	KduI/IolB family (KduI)	KduI/IolB family	This family includes the 5-keto 4-deoxyuronate isomerase enzyme EC:5.3.1.17 that is involved in pectin degradation. This family aldo includes bacterial Myo-inositol catabolism (IolB) proteins. The Bacillus subtilis inositol operon (iolABCDEFGHIJ) is ...	This family includes the 5-keto 4-deoxyuronate isomerase enzyme EC:5.3.1.17 that is involved in pectin degradation. This family aldo includes bacterial Myo-inositol catabolism (IolB) proteins. The Bacillus subtilis inositol operon (iolABCDEFGHIJ) is involved in myo-inositol catabolism. Glucose repression of the iol operon induced by inositol is exerted through catabolite repression mediated by CcpA and the iol induction system mediated by IolR [2]. The exact function of IolB is unknown. Members of this family possess a Cupin like structure.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity glucose-6-phosphate isomerase activity catalytic activity 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity cation binding transition metal ion binding zinc ion binding identical protein binding protein binding binding protein homodimerization activity protein dimerization activity isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity glucose-6-phosphate isomerase activity catalytic activity 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	catabolic process oxoacid metabolic process uronic acid metabolic process cellular metabolic process carboxylic acid metabolic process organic acid metabolic process organic acid catabolic process cellular catabolic process organic substance metabolic process monocarboxylic acid catabolic process D-glucuronate catabolic process glucuronate metabolic process carboxylic acid catabolic process small molecule metabolic process catabolic process oxoacid metabolic process uronic acid metabolic process cellular metabolic process carboxylic acid metabolic process organic acid metabolic process organic acid catabolic process cellular catabolic process organic substance metabolic process monocarboxylic acid catabolic process D-glucuronate catabolic process glucuronate metabolic process carboxylic acid catabolic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process small molecule catabolic process organic substance catabolic process D-glucuronate metabolic process glucuronate catabolic process monosaccharide metabolic process D-galacturonate catabolic process carbohydrate catabolic process D-galacturonate metabolic process galacturonate metabolic process carbohydrate metabolic process primary metabolic process monosaccharide catabolic process galacturonate catabolic process galacturonan metabolic process pectin metabolic process macromolecule catabolic process pectin catabolic process polysaccharide metabolic process polysaccharide catabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR021120	KduI/IolB isomerase	Family
A, B, C, D, E A, B, C, D, E, F	IPR007045	5-keto 4-deoxyuronate isomerase	Family
A, B, C, D, E A, B, C, D, E, F	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR027449	5-keto-4-deoxyuronate isomerase, N-terminal	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR011051	RmlC-like cupin domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.