1X51

Solution structure of the NUDIX domain from human A/G-specific adenine DNA glycosylase alpha-3 splice isoform

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1x51a1	Alpha and beta proteins (a+b)	Nudix	Nudix	MutY C-terminal domain-like	A/G-specific adenine DNA glycosylase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1x51a3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1x51a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	MutY C-terminal domain-like	8021224	4001553	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nudix	8033604	3000098	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	NUDIX_4	e1x51A1	A: a+b two layers	X: beta-Grasp	H: Nudix (From Topology)	T: Nudix	F: NUDIX_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.79.10	Alpha Beta	Alpha-Beta Complex	Nucleoside Triphosphate Pyrophosphohydrolase	Nucleoside Triphosphate Pyrophosphohydrolase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14815	NUDIX domain (NUDIX_4)	NUDIX domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	A/G-specific adenine DNA glycosylase	protein-containing complex binding binding MutSalpha complex binding mismatch repair complex binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding hydrolase activity, acting on glycosyl bonds oxidized base lesion DNA N-glycosylase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid oxidized purine nucleobase lesion DNA N-glycosylase activity hydrolase activity protein-containing complex binding binding MutSalpha complex binding mismatch repair complex binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding hydrolase activity, acting on glycosyl bonds oxidized base lesion DNA N-glycosylase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid oxidized purine nucleobase lesion DNA N-glycosylase activity hydrolase activity 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity DNA N-glycosylase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity DNA binding adenine/guanine mispair binding double-stranded DNA binding organic cyclic compound binding mismatched DNA binding nucleic acid binding purine-specific mismatch base pair DNA N-glycosylase activity mismatch base pair DNA N-glycosylase activity oxidized DNA binding oxidized purine DNA binding damaged DNA binding cation binding ion binding metal ion binding	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process base-excision repair organic substance metabolic process DNA modification cellular response to stress DNA damage response depurination response to stress macromolecule modification cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process base-excision repair organic substance metabolic process DNA modification cellular response to stress DNA damage response depurination response to stress macromolecule modification metabolic process cellular process macromolecule metabolic process base-excision repair, AP site formation DNA repair mismatch repair regulation of biological process regulation of cellular process necroptotic process negative regulation of programmed cell death negative regulation of necroptotic process biological regulation negative regulation of biological process programmed necrotic cell death regulation of programmed cell death cell death regulation of necroptotic process negative regulation of programmed necrotic cell death negative regulation of cellular process regulation of programmed necrotic cell death programmed cell death	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003265	HhH-GPD domain	Domain
A	IPR000445	Helix-hairpin-helix motif	Conserved Site
A	IPR023170	Helix-hairpin-helix, base-excision DNA repair, C-terminal	Homologous Superfamily
A	IPR015797	NUDIX hydrolase-like domain superfamily	Homologous Superfamily
A	IPR029119	Adenine DNA glycosylase, C-terminal	Domain
A	IPR011257	DNA glycosylase	Homologous Superfamily
A	IPR004036	Endonuclease III-like, conserved site-2	Conserved Site
A	IPR000086	NUDIX hydrolase domain	Domain
A	IPR044298	Adenine/Thymine-DNA glycosylase	Family
A	IPR004035	Endonuclease III, iron-sulphur binding site	Binding Site
A	IPR003651	Endonuclease III-like, iron-sulphur cluster loop motif	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UIF7	classic familial adenomatous polyposis MUTYH-related attenuated familial adenomatous polyposis pilomatrixoma gastric cancer malignant colon neoplasm colorectal cancer hereditary diffuse gastric adenocarcinoma malignant mesothelioma medulloblastoma peripheral nervous system disease Polyposis, Adenomatous Intestinal adenoma cancer colonic neoplasm endometrial cancer classic familial adenomatous polyposis MUTYH-related attenuated familial adenomatous polyposis pilomatrixoma gastric cancer malignant colon neoplasm colorectal cancer hereditary diffuse gastric adenocarcinoma malignant mesothelioma medulloblastoma peripheral nervous system disease Polyposis, Adenomatous Intestinal adenoma cancer colonic neoplasm endometrial cancer gastric carcinoma genetic intestinal polyposis Lynch syndrome peripheral neuropathy stomach carcinoma in situ benign colon neoplasm colorectal adenocarcinoma gastric neoplasm hereditary breast carcinoma benign neoplasm of stomach colon carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.