Annotations: 1X4K

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1x4ka1	Small proteins	Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	LIM domain	Four and a half LIM domains protein 2, FHL2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1x4ka4	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1x4ka3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	LIM domain	8021223	4003634	SCOP2 (2022-06-29)
A	SCOP2 Family	LIM domain	8021225	4003634	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Glucocorticoid receptor-like (DNA-binding domain)	8033603	3000068	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Glucocorticoid receptor-like (DNA-binding domain)	8033605	3000068	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e1x4kA1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00412	e1x4kA2	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: PF00412	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00412	LIM domain (LIM)	LIM domain	This family represents two copies of the LIM structural domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Skeletal muscle LIM-protein 3	transcription factor binding protein binding binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cation binding ion binding metal ion binding small molecule binding bHLH transcription factor binding DNA-binding transcription factor binding transcription factor binding protein binding binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cation binding ion binding metal ion binding small molecule binding bHLH transcription factor binding DNA-binding transcription factor binding identical protein binding	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation ventricular cardiac muscle cell differentiation cardiac muscle cell development cell development muscle cell differentiation striated muscle tissue development muscle structure development multicellular organism development developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation ventricular cardiac muscle cell differentiation cardiac muscle cell development cell development muscle cell differentiation striated muscle tissue development muscle structure development multicellular organism development muscle cell development anatomical structure development muscle tissue development cardiac cell development system development heart development cardiac muscle tissue development cardiac muscle cell differentiation animal organ development tissue development ventricular cardiac muscle cell development cardiocyte differentiation circulatory system development striated muscle cell differentiation atrial cardiac muscle cell differentiation atrial cardiac muscle cell development regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process calcineurin-NFAT signaling cascade cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication negative regulation of calcineurin-NFAT signaling cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of calcineurin-mediated signaling regulation of calcium-mediated signaling signal transduction regulation of calcineurin-NFAT signaling cascade regulation of signaling negative regulation of response to stimulus negative regulation of calcium-mediated signaling negative regulation of signal transduction calcium-mediated signaling regulation of response to stimulus regulation of cell communication negative regulation of calcineurin-mediated signaling calcineurin-mediated signaling cardiac chamber morphogenesis heart trabecula formation heart morphogenesis anatomical structure morphogenesis anatomical structure formation involved in morphogenesis cardiac chamber development animal organ morphogenesis heart trabecula morphogenesis trabecula formation trabecula morphogenesis response to organic substance response to hormone response to chemical response to endogenous stimulus	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001781	Zinc finger, LIM-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14192	acute myeloid leukemia breast carcinoma breast cancer Cardiomegaly malignant pancreatic neoplasm medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Pick disease adrenal cortex carcinoma ulcerative colitis familial isolated dilated cardiomyopathy lung adenocarcinoma malignant mesothelioma nasopharyngeal carcinoma acute myeloid leukemia breast carcinoma breast cancer Cardiomegaly malignant pancreatic neoplasm medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Pick disease adrenal cortex carcinoma ulcerative colitis familial isolated dilated cardiomyopathy lung adenocarcinoma malignant mesothelioma nasopharyngeal carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer astrocytic tumor dilated cardiomyopathy hepatocellular carcinoma lung cancer non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia spina bifida familial dilated cardiomyopathy malignant ependymoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.