Annotations: 1X3H

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1x3ha1	Small proteins	Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	LIM domain	Leupaxin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1x3ha4	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1x3ha3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	LIM domain	8021201	4003634	SCOP2 (2022-06-29)
A	SCOP2 Family	LIM domain	8021202	4003634	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Glucocorticoid receptor-like (DNA-binding domain)	8033581	3000068	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Glucocorticoid receptor-like (DNA-binding domain)	8033582	3000068	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LIM_C	e1x3hA2	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: LIM_C	ECOD (1.6)
A	LIM_N_1	e1x3hA1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: LIM_N_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.110.10	Mainly Beta	Ribbon	Cysteine Rich Protein	Cysteine Rich Protein	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00412	LIM domain (LIM)	LIM domain	This family represents two copies of the LIM structural domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Leupaxin	transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cation binding ion binding binding metal ion binding small molecule binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis cellular response to stimulus regulation of B cell receptor signaling pathway immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling negative regulation of signaling cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis cellular response to stimulus regulation of B cell receptor signaling pathway immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling negative regulation of signaling positive regulation of biological process negative regulation of biological process regulation of signal transduction regulation of antigen receptor-mediated signaling pathway negative regulation of antigen receptor-mediated signaling pathway negative regulation of cell communication cell communication negative regulation of B cell receptor signaling pathway positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response negative regulation of cellular process regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process regulation of signaling cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response negative regulation of response to stimulus B cell receptor signaling pathway biological regulation negative regulation of signal transduction regulation of response to stimulus negative regulation of immune system process immune system process regulation of immune response regulation of cell communication antigen receptor-mediated signaling pathway activation of immune response cell adhesion cell adhesion mediated by integrin regulation of cell adhesion mediated by integrin regulation of cell adhesion epithelium migration multicellular organismal process tissue migration endothelial cell migration ameboidal-type cell migration epithelial cell migration cell migration cell motility substrate adhesion-dependent cell spreading cell-substrate adhesion cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway negative regulation of cell adhesion	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen podosome cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm cytosol perinuclear region of cytoplasm cell periphery plasma membrane cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017305	Leupaxin/Paxillin/TGFB1I1	Family
A	IPR001781	Zinc finger, LIM-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O60711	ulcerative colitis Liver Cirrhosis, Experimental tuberculosis astrocytic tumor ductal breast carcinoma in situ interstitial cystitis lung cancer malignant glioma osteosarcoma Sjogren syndrome cutaneous lupus erythematosus glioblastoma invasive ductal breast carcinoma lung carcinoma malignant mesothelioma ulcerative colitis Liver Cirrhosis, Experimental tuberculosis astrocytic tumor ductal breast carcinoma in situ interstitial cystitis lung cancer malignant glioma osteosarcoma Sjogren syndrome cutaneous lupus erythematosus glioblastoma invasive ductal breast carcinoma lung carcinoma malignant mesothelioma ovarian cancer subependymal giant cell astrocytoma cystic fibrosis inflammatory bowel disease malignant colon neoplasm non-small cell lung carcinoma pilocytic astrocytoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.