Annotations: 1WR8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1wr8b_	Alpha and beta proteins (a/b)	HAD-like	HAD-like	Predicted hydrolases Cof	Phosphoglycolate phosphatase, PGPase	(Pyrococcus horikoshii OT3 ) [TaxId: 70601 ],	SCOPe (2.08)
A	d1wr8a_	Alpha and beta proteins (a/b)	HAD-like	HAD-like	Predicted hydrolases Cof	Phosphoglycolate phosphatase, PGPase	(Pyrococcus horikoshii OT3 ) [TaxId: 70601 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	HAD-like	8043682	3001890	SCOP2B (2022-06-29)
A	SCOP2 Family	Predicted hydrolases Cof	8031304	4002994	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HAD-like	8043682	3001890	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	F_UNCLASSIFIED	e1wr8B1	A: a+b two layers	X: Cof C2 cap domain (From Topology)	H: Cof C2 cap domain (From Topology)	T: Cof C2 cap domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF08282	e1wr8B2	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: PF08282	ECOD (1.6)
A	F_UNCLASSIFIED	e1wr8A2	A: a+b two layers	X: Cof C2 cap domain (From Topology)	H: Cof C2 cap domain (From Topology)	T: Cof C2 cap domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF08282	e1wr8A3	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: PF08282	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
B	3.90.1070.10	Alpha Beta	Alpha-Beta Complex	Hypothetical Protein Ta0175	Chain: A, domain 2	CATH (4.3.0)
A	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
A	3.90.1070.10	Alpha Beta	Alpha-Beta Complex	Hypothetical Protein Ta0175	Chain: A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00702	haloacid dehalogenase-like hydrolase (Hydrolase)	haloacid dehalogenase-like hydrolase	This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted fo ...	This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain [1]. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Phosphoglycolate phosphatase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding phosphoglycolate phosphatase activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity	carbohydrate metabolic process organic substance metabolic process primary metabolic process metabolic process dephosphorylation cellular metabolic process phosphate-containing compound metabolic process cellular process phosphorus metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036412	HAD-like superfamily	Homologous Superfamily
A, B	IPR023214	HAD superfamily	Homologous Superfamily
A, B	IPR006382	Phosphoglycolate phosphatase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.