1WMI

Crystal structure of archaeal RelE-RelB complex from Pyrococcus horikoshii OT3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1wmia1	Alpha and beta proteins (a+b)	RelE-like	RelE-like	RelE-like	Hypothetical protein PHS013	(Pyrococcus horikoshii OT3 ) [TaxId: 70601 ],	SCOPe (2.08)
C	d1wmic_	Alpha and beta proteins (a+b)	RelE-like	RelE-like	RelE-like	automated matches	(Pyrococcus horikoshii OT3 ) [TaxId: 70601 ],	SCOPe (2.08)
D	d1wmid_	All alpha proteins	Non-globular all-alpha subunits of globular proteins	RelB-like	automated matches	automated matches	(Pyrococcus horikoshii OT3 ) [TaxId: 70601 ],	SCOPe (2.08)
B	d1wmib1	All alpha proteins	Non-globular all-alpha subunits of globular proteins	RelB-like	RelB-like	Hypothetical protein PHS014	(Pyrococcus horikoshii OT3 ) [TaxId: 70601 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	RelE-like	8020727	4003388	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RelE-like	8033107	3000741	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	RelE-like	8033107	3000741	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RelB-like	8033108	3001878	SCOP2B (2022-06-29)
B	SCOP2 Family	relb-like	8020728	4001580	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	RelB-like	8033108	3001878	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ParE_toxin_1	e1wmiA1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: ParE_toxin_1	ECOD (1.6)
C	ParE_toxin_1	e1wmiC1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: ParE_toxin_1	ECOD (1.6)
D	EUF08775	e1wmiD1	A: extended segments	X: RelB-like (From Topology)	H: RelB-like (From Topology)	T: RelB-like	F: EUF08775	ECOD (1.6)
B	EUF08775	e1wmiB1	A: extended segments	X: RelB-like (From Topology)	H: RelB-like (From Topology)	T: RelB-like	F: EUF08775	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
C	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
D	6.10.250.250	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	6.10.250.250	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF05016	ParE toxin of type II toxin-antitoxin system, parDE (ParE_toxin)	ParE toxin of type II toxin-antitoxin system, parDE	ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralised by the antitoxin ParD. The family also encompasses RelE/ParE described in [2].	Domain
B, D	PF18881	Family of unknown function (DUF5646) (DUF5646)	Family of unknown function (DUF5646)	-	Family

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR007712	Toxin-antitoxin system, RelE/ParE toxin family	Family
A, C	IPR035093	Toxin-antitoxin system, RelE/ParE toxin domain superfamily	Homologous Superfamily
B, D	IPR043706	Protein of unknown function DUF5646	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.