Annotations: 1WAB

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1waba_	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Acetylhydrolase	Platelet-activating factor acetylhydrolase	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SGNH hydrolase-like	8044119	3001315	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13472	e1wabA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: PF13472	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	SGNH hydrolase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13472	GDSL-like Lipase/Acylhydrolase family (Lipase_GDSL_2)	GDSL-like Lipase/Acylhydrolase family	This family of presumed lipases and related enzymes are similar to Pfam:PF00657.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE	hydrolase activity, acting on ester bonds 1-alkyl-2-acetylglycerophosphocholine esterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity protein heterodimerization activity protein binding binding protein dimerization activity platelet-activating factor acetyltransferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity hydrolase activity, acting on ester bonds 1-alkyl-2-acetylglycerophosphocholine esterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity protein heterodimerization activity protein binding binding protein dimerization activity platelet-activating factor acetyltransferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity identical protein binding protein homodimerization activity	lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation	intracellular anatomical structure cytoplasm cellular anatomical entity protein-containing complex catalytic complex 1-alkyl-2-acetylglycerophosphocholine esterase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013830	SGNH hydrolase-type esterase domain	Domain
A	IPR036514	SGNH hydrolase superfamily	Homologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	1-alkyl-2-acetylglycerophosphocholine esterase M-CSA #94	2-acetyl-1-alkylglycerophosphocholine esterase, also known as known as platelet-activating factor acetylhydrolase (PAF-AH). Mammalian brain contains significant levels of platelet activating-factor (PAF), these act as a synapse messenger and transcription inducer of the early response genes c-fos and c-jun. The platelet-activating factor PAF is a potent lipid first messenger active in general cell activation, fertilisation, inflammatory and allergic reactions, asthma, HIV pathogenesis, carcinogenesis, and apoptosis. PAF has also been implicated as a messenger in long-term potentiation, a cellular model of memory formation. Inactivation of this factor is carried out by PAF-AH, a subfamily of phospholipases A2 that remove the sn-2 acetyl group. Mammalian brain contains at least three intracellular isoforms, 1b being the best characterised. From experimentation it can be assumed that PAF-AH maintains the PAF concentration within a certain range during brain development. The protein is an unusual G-protein like (alpha1/alpha2)beta trimer. PAF-AH is a heterotrimer composed of 26-,26-, and 45-Kda polypeptides. The alpha (26KDa) is the catalytic subunit. The active site is made up of a trypsin-like triad of Ser 47, His 195 and Asp 192. The other subunit is not essential for the catalytic activity. The catalytic subunit contains a single alpha/beta domain with a central, parallel, 6-stranded beta sheet. This fold is very like that found in GTPase. Experimental data has demonstrated that the catalytic subunit of brain PAF acetylhydrolase is a novel type of serine esterase.	Defined by 5 residues: SER:A-47GLY:A-74ASN:A-104ASP:A-192HIS:A-195 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 3.1.1.47 (PDB Primary Data) Search M-CSA Motif + EC 3.1.1.47

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.