Annotations: 1WA5

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1wa5a_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Ran	Dog (Canis lupus familiaris ) [TaxId: 9615 ],	SCOPe (2.08)
B	d1wa5b_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	Karyopherin alpha	Baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d1wa5c_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	Exportin Cse1p	Baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ras-like monodomain GTPases	8060225	4004043	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ras-like P-loop GTPases	8060226	3002022	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8043374	3000116	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ARM repeat-like	8043375	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ras	e1wa5A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
B	Arm	e1wa5B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Arm	ECOD (1.6)
C	Cse1	e1wa5C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Cse1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
C	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain
B	PF00514	Armadillo/beta-catenin-like repeat (Arm)	Armadillo/beta-catenin-like repeat	-	Repeat
B	PF01749	Importin beta binding domain (IBB)	Importin beta binding domain	-	Repeat
B	PF16186	Atypical Arm repeat (Arm_3)	Atypical Arm repeat	-	Repeat
C	PF03378	CAS/CSE protein, C-terminus (CAS_CSE1)	CAS/CSE protein, C-terminus	-	Repeat
C	PF08506	Cse1 (Cse1)	Cse1	-	Repeat
C	PF03810	Importin-beta N-terminal domain (IBN_N)	Importin-beta N-terminal domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	GTP-binding nuclear protein Ran	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding nucleocytoplasmic carrier activity nuclear export signal receptor activity molecular carrier activity cation binding magnesium ion binding metal ion binding RISC complex binding ribonucleoprotein complex binding protein-containing complex binding RNA binding nucleic acid binding pre-miRNA binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	nitrogen compound transport regulation of cellular process nucleocytoplasmic transport nuclear transport negative regulation of biological process negative regulation of cellular metabolic process localization post-transcriptional regulation of gene expression establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export regulation of biological process RNA transport nitrogen compound transport regulation of cellular process nucleocytoplasmic transport nuclear transport negative regulation of biological process negative regulation of cellular metabolic process localization post-transcriptional regulation of gene expression establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export regulation of biological process RNA transport organic substance transport cellular metabolic process negative regulation of metabolic process pre-miRNA export from nucleus intracellular transport regulation of cellular metabolic process establishment of localization negative regulation of cellular biosynthetic process RNA export from nucleus miRNA-mediated post-transcriptional gene silencing regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular localization transport cellular biosynthetic process organic substance metabolic process negative regulation of cellular process nucleobase-containing compound transport negative regulation of macromolecule metabolic process regulation of biosynthetic process nucleic acid transport biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process establishment of RNA localization negative regulation of biosynthetic process macromolecule localization cellular process protein localization establishment of protein localization protein export from nucleus protein transport cellular macromolecule localization intracellular protein transport cell division establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus protein-containing complex localization cellular component biogenesis ribosome biogenesis organelle localization cellular component organization or biogenesis ribosome localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein localization to organelle protein import into nucleus mitotic nuclear division organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process mitotic sister chromatid segregation nuclear chromosome segregation cell cycle chromosome segregation cell cycle process regulation of localization regulation of protein localization positive regulation of nucleocytoplasmic transport positive regulation of biological process positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of intracellular transport regulation of protein export from nucleus positive regulation of cellular process regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of nucleocytoplasmic transport regulation of protein transport positive regulation of protein export from nucleus positive regulation of transport regulation of cellular localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport RNA import into nucleus snRNA import into nucleus snRNA transport ribose phosphate metabolic process GTP metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process purine nucleoside triphosphate metabolic process organonitrogen compound metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process	protein-containing complex ribonucleoprotein complex RNAi effector complex RISC complex membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle protein-containing complex ribonucleoprotein complex RNAi effector complex RISC complex membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle organelle envelope nuclear envelope nucleus endomembrane system cytosol
B	SRP1 isoform 1	protein-containing complex binding binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity disordered domain specific binding protein binding protein domain specific binding nuclear localization sequence binding signal sequence binding peptide binding	localization cellular localization import into nucleus nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization protein localization establishment of protein localization NLS-bearing protein import into nucleus nitrogen compound transport localization cellular localization import into nucleus nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization protein localization establishment of protein localization NLS-bearing protein import into nucleus nitrogen compound transport cellular macromolecule localization protein import into nucleus organic substance transport protein localization to nucleus establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle intracellular protein transport proteasome localization protein-containing complex localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane protein targeting to membrane	protein-containing complex nucleocytoplasmic transport complex NLS-dependent protein nuclear import complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm protein-containing complex nucleocytoplasmic transport complex NLS-dependent protein nuclear import complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol perinuclear region of cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
C	Importin alpha re-exporter	small GTPase binding protein binding binding enzyme binding GTPase binding nucleocytoplasmic carrier activity nuclear export signal receptor activity molecular carrier activity	cellular process cell cycle protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization nucleocytoplasmic transport transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of biological process cellular process cell cycle protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization nucleocytoplasmic transport transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of biological process positive regulation of establishment of protein localization positive regulation of protein transport localization cellular macromolecule localization establishment of localization in cell positive regulation of intracellular transport nuclear export regulation of protein export from nucleus positive regulation of cellular process regulation of intracellular transport regulation of biological process regulation of transport organic substance transport biological regulation regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport regulation of protein transport protein export from nucleus positive regulation of protein export from nucleus establishment of localization positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport cell division RNA import into nucleus RNA transport nucleic acid transport snRNA import into nucleus import into nucleus establishment of RNA localization RNA localization nucleobase-containing compound transport snRNA transport protein localization to nucleus establishment of protein localization to organelle protein localization to organelle protein import into nucleus	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002041	Ran GTPase	Family
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR001806	Small GTPase	Family
A	IPR005225	Small GTP-binding protein domain	Domain
B	IPR002652	Importin-alpha, importin-beta-binding domain	Domain
B	IPR016024	Armadillo-type fold	Homologous Superfamily
B	IPR000225	Armadillo	Repeat
B	IPR011989	Armadillo-like helical	Homologous Superfamily
B	IPR024931	Importin subunit alpha	Family
B	IPR036975	Importin-alpha, importin-beta-binding domain superfamily	Homologous Superfamily
B	IPR032413	Atypical Arm repeat	Repeat
C	IPR013713	Exportin-2, central domain	Domain
C	IPR016024	Armadillo-type fold	Homologous Superfamily
C	IPR005043	Exportin-2, C-terminal	Domain
C	IPR001494	Importin-beta, N-terminal domain	Domain
C	IPR011989	Armadillo-like helical	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.