1W7Z

Crystal structure of the free (uncomplexed) Ecballium elaterium trypsin inhibitor (EETI-II)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1w7za_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Plant inhibitors of proteinases and amylases	Plant inhibitors of proteinases and amylases	automated matches	SQUIRTING CUCUMBER (Ecballium elaterium ) [TaxId: 3679 ],	SCOPe (2.08)
B	d1w7zb_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Plant inhibitors of proteinases and amylases	Plant inhibitors of proteinases and amylases	automated matches	SQUIRTING CUCUMBER (Ecballium elaterium ) [TaxId: 3679 ],	SCOPe (2.08)
C	d1w7zc_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Plant inhibitors of proteinases and amylases	Plant inhibitors of proteinases and amylases	automated matches	SQUIRTING CUCUMBER (Ecballium elaterium ) [TaxId: 3679 ],	SCOPe (2.08)
D	d1w7zd_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Plant inhibitors of proteinases and amylases	Plant inhibitors of proteinases and amylases	automated matches	SQUIRTING CUCUMBER (Ecballium elaterium ) [TaxId: 3679 ],	SCOPe (2.08)
F	d1w7zf_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Plant inhibitors of proteinases and amylases	Plant inhibitors of proteinases and amylases	automated matches	SQUIRTING CUCUMBER (Ecballium elaterium ) [TaxId: 3679 ],	SCOPe (2.08)
G	d1w7zg_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Plant inhibitors of proteinases and amylases	Plant inhibitors of proteinases and amylases	automated matches	SQUIRTING CUCUMBER (Ecballium elaterium ) [TaxId: 3679 ],	SCOPe (2.08)
H	d1w7zh_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Plant inhibitors of proteinases and amylases	Plant inhibitors of proteinases and amylases	automated matches	SQUIRTING CUCUMBER (Ecballium elaterium ) [TaxId: 3679 ],	SCOPe (2.08)
E	d1w7ze_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Plant inhibitors of proteinases and amylases	Plant inhibitors of proteinases and amylases	automated matches	SQUIRTING CUCUMBER (Ecballium elaterium ) [TaxId: 3679 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Plant inhibitors of proteinases and amylases	8026900	4003054	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Plant inhibitors of proteinases and amylases	8039279	3000215	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Plant inhibitors of proteinases and amylases	8039279	3000215	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Plant inhibitors of proteinases and amylases	8039279	3000215	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Plant inhibitors of proteinases and amylases	8039279	3000215	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Plant inhibitors of proteinases and amylases	8039279	3000215	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Plant inhibitors of proteinases and amylases	8039279	3000215	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Plant inhibitors of proteinases and amylases	8039279	3000215	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Plant inhibitors of proteinases and amylases	8039279	3000215	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00299	e1w7zA1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: PF00299	ECOD (1.6)
B	PF00299	e1w7zB1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: PF00299	ECOD (1.6)
C	PF00299	e1w7zC1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: PF00299	ECOD (1.6)
D	PF00299	e1w7zD1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: PF00299	ECOD (1.6)
F	PF00299	e1w7zF1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: PF00299	ECOD (1.6)
G	PF00299	e1w7zG1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: PF00299	ECOD (1.6)
H	PF00299	e1w7zH1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: PF00299	ECOD (1.6)
E	PF00299	e1w7zE1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: PF00299	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00299	Squash family serine protease inhibitor (Squash)	Squash family serine protease inhibitor	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	TRYPSIN INHIBITOR II	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011052	Proteinase/amylase inhibitor domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000737	Proteinase inhibitor I7, squash	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.