1W7J

Crystal Structure Of Myosin V Motor With Essential Light Chain + ADP-BeFx - Near Rigor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1w7ja1	All beta proteins	SH3-like barrel	Myosin S1 fragment, N-terminal domain	Myosin S1 fragment, N-terminal domain	Myosin S1 fragment, N-terminal domain	CHICKEN (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
A	d1w7ja2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Motor proteins	Myosin S1, motor domain	CHICKEN (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d1w7jb_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Myosin s1 fragment N-terminal domain	8020545	4001735	SCOP2 (2022-06-29)
A	SCOP2 Family	Myosin motor domain	8020546	4004054	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Myosin s1 fragment N-terminal domain	8032925	3000319	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	P-loop motor domain	8032926	3002036	SCOP2 (2022-06-29)
B	SCOP2 Family	Calmodulin-like	8020547	4000924	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	EF-hand	8032927	3001983	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Myosin_N_1	e1w7jA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Myosin_N_1	ECOD (1.6)
A	IQ_1	e1w7jA3	A: alpha bundles	X: Myosin VI lever arm (From Topology)	H: Myosin VI lever arm (From Topology)	T: Myosin VI lever arm	F: IQ_1	ECOD (1.6)
A	Myosin_head	e1w7jA4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Myosin_head	ECOD (1.6)
B	EF-hand_7_8	e1w7jB2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
B	EF-hand_7_5	e1w7jB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00612	IQ calmodulin-binding motif (IQ)	IQ calmodulin-binding motif	-	Motif
A	PF00063	Myosin head (motor domain) (Myosin_head)	Myosin head (motor domain)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	MYOSIN VA	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding cytoskeletal motor activity minus-end directed microfilament motor activity microfilament motor activity ATP-dependent activity	protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization cellular process localization within membrane protein localization to membrane transport establishment of localization vesicle-mediated transport cellular response to stimulus protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization cellular process localization within membrane protein localization to membrane transport establishment of localization vesicle-mediated transport cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone response to chemical response to insulin cellular response to organic substance cellular response to insulin stimulus cellular response to hormone stimulus vesicle transport along actin filament vesicle cytoskeletal trafficking vesicle localization establishment of organelle localization establishment of vesicle localization intracellular transport actin filament-based movement organelle localization establishment of localization in cell actin filament-based process cytoskeleton-dependent intracellular transport actin filament-based transport cellular component organization organelle organization actin cytoskeleton organization actin filament organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization	membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular organelle intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm protein-containing complex myosin complex Golgi membrane membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular organelle intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm protein-containing complex myosin complex Golgi membrane Golgi apparatus membrane intracellular membrane-bounded organelle endomembrane system bounding membrane of organelle organelle membrane polymeric cytoskeletal fiber actin filament filamentous actin supramolecular fiber supramolecular polymer supramolecular complex intracellular vesicle insulin-responsive compartment cytoplasmic vesicle secretory granule secretory vesicle
B	MYOSIN LIGHT CHAIN 1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding structural molecule activity structural constituent of muscle cytoskeletal motor activity	multicellular organismal process system process muscle contraction muscle system process developmental process muscle structure development skeletal muscle organ development skeletal muscle tissue development anatomical structure development animal organ development muscle tissue development muscle organ development tissue development muscle filament sliding multicellular organismal process system process muscle contraction muscle system process developmental process muscle structure development skeletal muscle organ development skeletal muscle tissue development anatomical structure development animal organ development muscle tissue development muscle organ development tissue development muscle filament sliding actin filament-based process cellular process actin-mediated cell contraction actin filament-based movement actin-myosin filament sliding	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton myosin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle myosin II complex non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton myosin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle myosin II complex non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber muscle myosin complex supramolecular polymer supramolecular complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol unconventional myosin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR002710	Dilute domain	Domain
A	IPR000048	IQ motif, EF-hand binding site	Binding Site
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR036103	Class V myosin, motor domain	Domain
A	IPR037988	Myosin 5a, cargo-binding domain	Domain
A	IPR001609	Myosin head, motor domain	Domain
A	IPR004009	Myosin, N-terminal, SH3-like	Domain
B	IPR002048	EF-hand domain	Domain
B	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P14649	keloid allergic rhinitis asthma ovarian cancer alopecia areata attention deficit hyperactivity disorder, inattentive type lung cancer polycystic ovary syndrome anorexia nervosa Hashimoto thyroiditis myopathy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.