Annotations: 1W6J

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1w6ja2	All alpha proteins	alpha/alpha toroid	Terpenoid cyclases/Protein prenyltransferases	Terpene synthases	Lanosterol synthase, middle domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1w6ja1	All alpha proteins	alpha/alpha toroid	Terpenoid cyclases/Protein prenyltransferases	Terpene synthases	Lanosterol synthase, N- and C-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Terpene synthases	8030915	4001191	SCOP2 (2022-06-29)
A	SCOP2 Family	Terpene synthases	8030916	4001191	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Terpenoid cyclases/Protein prenyltransferases	8043294	3001024	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Terpenoid cyclases/Protein prenyltransferases	8043295	3001024	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13243	e1w6jA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: PF13243	ECOD (1.6)
A	PF13249	e1w6jA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: PF13249	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.20.120.20	Special	Other non-globular	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
A	1.50.10.20	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00432	Prenyltransferase and squalene oxidase repeat (Prenyltrans)	Prenyltransferase and squalene oxidase repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	LANOSTEROL SYNTHASE	isomerase activity lanosterol synthase activity catalytic activity oxidosqualene cyclase activity intramolecular transferase activity	regulation of protein stability biological regulation regulation of biological quality steroid metabolic process lipid biosynthetic process primary metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process steroid biosynthetic process lipid metabolic process regulation of protein stability biological regulation regulation of biological quality steroid metabolic process lipid biosynthetic process primary metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process steroid biosynthetic process lipid metabolic process organic hydroxy compound metabolic process sterol metabolic process cholesterol metabolic process alcohol metabolic process small molecule metabolic process secondary alcohol biosynthetic process small molecule biosynthetic process cholesterol biosynthetic process secondary alcohol metabolic process sterol biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process triterpenoid biosynthetic process triterpenoid metabolic process isoprenoid biosynthetic process cellular biosynthetic process cellular metabolic process terpenoid biosynthetic process cellular lipid metabolic process cellular process terpenoid metabolic process isoprenoid metabolic process	membrane cellular anatomical entity lipid droplet intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network membrane cellular anatomical entity lipid droplet intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032697	Squalene cyclase, N-terminal	Domain
A	IPR032696	Squalene cyclase, C-terminal	Domain
A	IPR018333	Squalene cyclase	Family
A	IPR002365	Terpene synthase, conserved site	Conserved Site
A	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P48449	cataract 44 Q fever oligodendroglioma Pick disease testicular cancer Acute Q fever breast fibroadenoma cutaneous lupus erythematosus hypotrichosis lung cancer malignant glioma osteosarcoma pituitary cancer spinal stenosis testicular germ cell tumor cataract 44 Q fever oligodendroglioma Pick disease testicular cancer Acute Q fever breast fibroadenoma cutaneous lupus erythematosus hypotrichosis lung cancer malignant glioma osteosarcoma pituitary cancer spinal stenosis testicular germ cell tumor astrocytic tumor cataract esophageal adenocarcinoma large cell medulloblastoma lysosomal lipid storage disorder medulloblastoma ovarian cancer psoriasis spondylolisthesis atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.