1W6F

Arylamine N-acetyltransferase from Mycobacterium smegmatis with the anti-tubercular drug isoniazid bound in the active site.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1w6fc_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Arylamine N-acetyltransferase	Arylamine N-acetyltransferase	(Mycolicibacterium smegmatis ) [TaxId: 1772 ],	SCOPe (2.08)
A	d1w6fa_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Arylamine N-acetyltransferase	Arylamine N-acetyltransferase	(Mycolicibacterium smegmatis ) [TaxId: 1772 ],	SCOPe (2.08)
B	d1w6fb_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Arylamine N-acetyltransferase	Arylamine N-acetyltransferase	(Mycolicibacterium smegmatis ) [TaxId: 1772 ],	SCOPe (2.08)
D	d1w6fd_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Arylamine N-acetyltransferase	Arylamine N-acetyltransferase	(Mycolicibacterium smegmatis ) [TaxId: 1772 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Cysteine proteinases	8032881	3001808	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Cysteine proteinases	8032881	3001808	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cysteine proteinases	8032881	3001808	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cysteine proteinases	8032881	3001808	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PF00797	e1w6fC1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00797	ECOD (1.6)
A	PF00797	e1w6fA1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00797	ECOD (1.6)
B	PF00797	e1w6fB1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00797	ECOD (1.6)
D	PF00797	e1w6fD1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00797	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.30.2140.10	Alpha Beta	2-Layer Sandwich	Arylamine N-acetyltransferase fold	Arylamine N-acetyltransferase	CATH (4.3.0)
C	2.40.128.150	Mainly Beta	Beta Barrel	Lipocalin	Cysteine proteinases	CATH (4.3.0)
A	3.30.2140.10	Alpha Beta	2-Layer Sandwich	Arylamine N-acetyltransferase fold	Arylamine N-acetyltransferase	CATH (4.3.0)
A	2.40.128.150	Mainly Beta	Beta Barrel	Lipocalin	Cysteine proteinases	CATH (4.3.0)
B	3.30.2140.10	Alpha Beta	2-Layer Sandwich	Arylamine N-acetyltransferase fold	Arylamine N-acetyltransferase	CATH (4.3.0)
B	2.40.128.150	Mainly Beta	Beta Barrel	Lipocalin	Cysteine proteinases	CATH (4.3.0)
D	3.30.2140.10	Alpha Beta	2-Layer Sandwich	Arylamine N-acetyltransferase fold	Arylamine N-acetyltransferase	CATH (4.3.0)
D	2.40.128.150	Mainly Beta	Beta Barrel	Lipocalin	Cysteine proteinases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00797	N-acetyltransferase (Acetyltransf_2)	N-acetyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	ARYLAMINE N-ACETYLTRANSFERASE	acetyltransferase activity N-acetyltransferase activity acyltransferase activity arylamine N-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A, B, C, D	IPR001447	Arylamine N-acetyltransferase	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.