Annotations: 1W0O

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1w0oa1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Vibrio cholerae sialidase, N-terminal and insertion domains	Vibrio cholerae sialidase, N-terminal and insertion domains	(Vibrio cholerae ) [TaxId: 666 ],	SCOPe (2.08)
A	d1w0oa3	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Vibrio cholerae sialidase	(Vibrio cholerae ) [TaxId: 666 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041559	3000120	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041557	3000120	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Sialidases	8041558	3001607	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Sialidases	8041558	3001607	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sial-lect-inser	e1w0oA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Sial-lect-inser	ECOD (1.6)
A	BNR_2	e1w0oA3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: BNR_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
A	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09264	Vibrio cholerae sialidase, lectin insertion (Sial-lect-inser)	Vibrio cholerae sialidase, lectin insertion	Members of this family are predominantly found in Vibrio cholerae sialidase, and adopt a beta sandwich structure consisting of 12-14 strands arranged in two beta-sheets. They bind to lectins with high affinity helping to target the protein to sialic ...	Members of this family are predominantly found in Vibrio cholerae sialidase, and adopt a beta sandwich structure consisting of 12-14 strands arranged in two beta-sheets. They bind to lectins with high affinity helping to target the protein to sialic acid-rich environments, thereby enhancing the catalytic efficiency of the enzyme [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SIALIDASE	sialic acid binding organic acid binding binding ion binding anion binding carboxylic acid binding carbohydrate derivative binding small molecule binding hydrolase activity, acting on glycosyl bonds exo-alpha-(2->6)-sialidase activity alpha-sialidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity exo-alpha-sialidase activity sialic acid binding organic acid binding binding ion binding anion binding carboxylic acid binding carbohydrate derivative binding small molecule binding hydrolase activity, acting on glycosyl bonds exo-alpha-(2->6)-sialidase activity alpha-sialidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity exo-alpha-sialidase activity catalytic activity exo-alpha-(2->8)-sialidase activity exo-alpha-(2->3)-sialidase activity	carbohydrate metabolic process organic substance metabolic process catabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process primary metabolic process metabolic process organic substance catabolic process sphingolipid catabolic process ganglioside catabolic process glycolipid metabolic process carbohydrate derivative metabolic process cellular lipid catabolic process carbohydrate metabolic process organic substance metabolic process catabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process primary metabolic process metabolic process organic substance catabolic process sphingolipid catabolic process ganglioside catabolic process glycolipid metabolic process carbohydrate derivative metabolic process cellular lipid catabolic process cellular catabolic process ceramide catabolic process amide metabolic process membrane lipid metabolic process organonitrogen compound catabolic process ceramide metabolic process carbohydrate derivative catabolic process glycosphingolipid catabolic process lipid catabolic process organonitrogen compound metabolic process glycosphingolipid metabolic process cellular metabolic process liposaccharide metabolic process sphingolipid metabolic process membrane lipid catabolic process glycolipid catabolic process cellular lipid metabolic process cellular process ganglioside metabolic process lipid metabolic process	membrane cellular anatomical entity extracellular region membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015344	Vibrio cholerae neuraminidase, lectin-like domain	Domain
A	IPR011040	Sialidase	Domain
A	IPR036278	Sialidase superfamily	Homologous Superfamily
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR026856	Sialidase family	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.