1VFG

Crystal structure of tRNA nucleotidyltransferase complexed with a primer tRNA and an incoming ATP analog

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1vfga1	All alpha proteins	Poly A polymerase C-terminal region-like	Poly A polymerase C-terminal region-like	Poly A polymerase C-terminal region-like	Poly A polymerase PcnB	(Aquifex aeolicus ) [TaxId: 63363 ],	SCOPe (2.08)
C [auth A]	d1vfga2	Alpha and beta proteins (a+b)	Nucleotidyltransferase	Nucleotidyltransferase	Poly A polymerase head domain-like	Poly A polymerase PcnB	(Aquifex aeolicus ) [TaxId: 63363 ],	SCOPe (2.08)
D [auth B]	d1vfgb1	All alpha proteins	Poly A polymerase C-terminal region-like	Poly A polymerase C-terminal region-like	Poly A polymerase C-terminal region-like	Poly A polymerase PcnB	(Aquifex aeolicus ) [TaxId: 63363 ],	SCOPe (2.08)
D [auth B]	d1vfgb2	Alpha and beta proteins (a+b)	Nucleotidyltransferase	Nucleotidyltransferase	Poly A polymerase head domain-like	Poly A polymerase PcnB	(Aquifex aeolicus ) [TaxId: 63363 ],	SCOPe (2.08)
D [auth B]	d1vfgb3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Aquifex aeolicus ) [TaxId: 63363 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	Poly A polymerase C-terminal region-like	8028948	4002497	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Family	Poly A polymerase head domain-like	8028950	4003222	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	Poly A polymerase C-terminal region-like	8041327	3001334	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	Nucleotidyltransferase-like	8041329	3000129	SCOP2 (2022-06-29)
D [auth B]	SCOP2B Superfamily	Poly A polymerase C-terminal region-like	8041327	3001334	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	Nucleotidyltransferase-like	8041329	3000129	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	F_UNCLASSIFIED	e1vfgA1	A: alpha complex topology	X: PDEase-like	H: Poly A polymerase C-terminal region-like (From Topology)	T: Poly A polymerase C-terminal region-like	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth A]	PF01743	e1vfgA2	A: a+b three layers	X: Nucleotidyltransferase-like	H: Nucleotidyltransferase (From Topology)	T: Nucleotidyltransferase	F: PF01743	ECOD (1.6)
D [auth B]	F_UNCLASSIFIED	e1vfgB1	A: alpha complex topology	X: PDEase-like	H: Poly A polymerase C-terminal region-like (From Topology)	T: Poly A polymerase C-terminal region-like	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth B]	PF01743	e1vfgB2	A: a+b three layers	X: Nucleotidyltransferase-like	H: Nucleotidyltransferase (From Topology)	T: Nucleotidyltransferase	F: PF01743	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	3.30.460.10	Alpha Beta	2-Layer Sandwich	Beta Polymerase	domain 2	CATH (4.3.0)
C [auth A]	1.10.3090.10	Mainly Alpha	Orthogonal Bundle	cca-adding enzyme, domain 2	cca-adding enzyme, domain 2	CATH (4.3.0)
D [auth B]	3.30.460.10	Alpha Beta	2-Layer Sandwich	Beta Polymerase	domain 2	CATH (4.3.0)
D [auth B]	1.10.3090.10	Mainly Alpha	Orthogonal Bundle	cca-adding enzyme, domain 2	cca-adding enzyme, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth B]	PF01743	Poly A polymerase head domain (PolyA_pol)	Poly A polymerase head domain	This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25 ...	This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D]	RNA (75-MER)	-	-	-
C [auth A], D [auth B]	poly A polymerase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding adenylyltransferase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups RNA binding tRNA binding nucleic acid binding cation binding metal ion binding	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process tRNA processing ncRNA metabolic process organic substance biosynthetic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process tRNA processing ncRNA metabolic process organic substance biosynthetic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process RNA processing RNA 3'-end processing	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth B]	IPR046342	CBS domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR043519	Nucleotidyltransferase superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR000644	CBS domain	Domain
C [auth A], D [auth B]	IPR002646	Poly A polymerase, head domain	Domain
C [auth A], D [auth B]	IPR038763	DHH phosphoesterase superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR003156	DHHA1 domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.