Annotations: 1VCS

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1vcsa1	All alpha proteins	STAT-like	t-snare proteins	t-snare proteins	Vesicle transport v-SNARE protein Vti1-like 2	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1vcsa3	Artifacts	Tags	Tags	Tags	C-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1vcsa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	t-snare proteins	8020771	4000986	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	t-snare proteins	8033151	3000366	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05008	e1vcsA1	A: alpha bundles	X: STAT-like	H: t-snare proteins (From Topology)	T: t-snare proteins	F: PF05008	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.400	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05008	Vesicle transport v-SNARE protein N-terminus (V-SNARE)	Vesicle transport v-SNARE protein N-terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Vesicle transport through interaction with t-SNAREs homolog 1A	SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding SNARE binding	cellular localization post-Golgi vesicle-mediated transport transport intracellular transport establishment of localization vesicle-mediated transport Golgi to vacuole transport localization establishment of localization in cell vacuolar transport cellular process Golgi vesicle transport synaptic vesicle to endosome fusion endosomal transport cellular localization post-Golgi vesicle-mediated transport transport intracellular transport establishment of localization vesicle-mediated transport Golgi to vacuole transport localization establishment of localization in cell vacuolar transport cellular process Golgi vesicle transport synaptic vesicle to endosome fusion endosomal transport synaptic vesicle endosomal processing organelle fusion cellular component organization vesicle organization organelle organization endosome organization cellular component organization or biogenesis endomembrane system organization voluntary musculoskeletal movement multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport macroautophagy cytosolic transport retrograde transport, endosome to Golgi membrane organization membrane fusion organelle membrane fusion vesicle fusion with Golgi apparatus vesicle fusion Golgi organization localization within membrane endocytic recycling vesicle-mediated transport to the plasma membrane	membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm vesicle cytosol SNARE complex membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm vesicle cytosol SNARE complex protein-containing complex membrane membrane protein complex endosome membrane endosome late endosome membrane endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane late endosome organelle membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane vacuole autophagosome neuron to neuron synapse synapse cell junction hippocampal mossy fiber to CA3 synapse cell projection neuron projection terminus neuron projection plasma membrane bounded cell projection Golgi apparatus Golgi membrane perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body transport vesicle transport vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane presynapse synaptic vesicle secretory vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038407	Vesicle transport v-SNARE, N-terminal domain superfamily	Homologous Superfamily
A	IPR000727	Target SNARE coiled-coil homology domain	Domain
A	IPR027027	GOSR2/Membrin/Bos1	Family
A	IPR007705	Vesicle transport v-SNARE, N-terminal	Domain
A	IPR010989	SNARE	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.