Annotations: 1VAE

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1vaea1	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	Rhophilin-2	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1vaea3	Artifacts	Tags	Tags	Tags	C-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1vaea2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PDZ domain	8028857	4001790	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PDZ domain-like	8041236	3000388	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e1vaeA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03097	BRO1-like domain (BRO1)	BRO1-like domain	-	Repeat
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	rhophilin, Rho GTPase binding protein 2	-	regulation of cytoskeleton organization regulation of cellular process regulation of cellular component organization regulation of actin filament-based process negative regulation of biological process regulation of actin filament bundle assembly cellular component biogenesis cellular component organization cellular component assembly actin filament bundle organization actin filament-based process negative regulation of cellular process cellular component organization or biogenesis stress fiber assembly regulation of cytoskeleton organization regulation of cellular process regulation of cellular component organization regulation of actin filament-based process negative regulation of biological process regulation of actin filament bundle assembly cellular component biogenesis cellular component organization cellular component assembly actin filament bundle organization actin filament-based process negative regulation of cellular process cellular component organization or biogenesis stress fiber assembly negative regulation of supramolecular fiber organization regulation of biological process regulation of actin filament organization negative regulation of stress fiber assembly actin cytoskeleton organization actomyosin structure organization negative regulation of cellular component organization negative regulation of cytoskeleton organization biological regulation actin filament organization regulation of cellular component biogenesis negative regulation of actin filament bundle assembly regulation of organelle organization regulation of stress fiber assembly organelle organization negative regulation of organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process supramolecular fiber organization cytoskeleton organization cellular response to stimulus response to stimulus signaling signal transduction cell communication multicellular organismal process renal system process system process glomerular filtration renal filtration	intracellular anatomical structure perinuclear region of cytoplasm cytoplasm cellular anatomical entity cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004328	BRO1 domain	Domain
A	IPR036274	HR1 repeat superfamily	Homologous Superfamily
A	IPR047138	Rhophilin-1/2	Family
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR011072	HR1 rho-binding domain	Domain
A	IPR047902	Rhophilin-2, BRO1 domain	Domain
A	IPR038499	BRO1 domain superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain
A	IPR049603	Rhophilin-2, HR1 domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.