Annotations: 1VA8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1va8a1	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	Maguk p55 subfamily member 5	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1va8a3	Artifacts	Tags	Tags	Tags	C-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1va8a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PDZ domain	8020694	4001790	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PDZ domain-like	8033074	3000388	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e1va8A1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	MAGUK p55 subfamily member 5	protein binding binding protein domain specific binding nucleobase-containing compound kinase activity nucleoside monophosphate kinase activity kinase activity transferase activity guanylate kinase activity catalytic activity phosphotransferase activity, phosphate group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding protein binding binding protein domain specific binding nucleobase-containing compound kinase activity nucleoside monophosphate kinase activity kinase activity transferase activity guanylate kinase activity catalytic activity phosphotransferase activity, phosphate group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding	developmental process multicellular organismal process cellular developmental process central nervous system neuron development cell development nervous system development generation of neurons central nervous system neuron differentiation multicellular organism development neurogenesis central nervous system development neuron differentiation cell differentiation neuron development anatomical structure development developmental process multicellular organismal process cellular developmental process central nervous system neuron development cell development nervous system development generation of neurons central nervous system neuron differentiation multicellular organism development neurogenesis central nervous system development neuron differentiation cell differentiation neuron development anatomical structure development cellular process system development tissue morphogenesis anatomical structure morphogenesis epithelium development morphogenesis of an epithelium tissue development morphogenesis of an epithelial sheet membrane organization cellular component organization plasma membrane organization cellular component organization or biogenesis endomembrane system organization protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular response to stimulus cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process response to stimulus signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction regulation of transforming growth factor beta receptor signaling pathway cell communication cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus biological regulation response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway cellular component assembly involved in morphogenesis myelin assembly cellular component biogenesis myelination cellular anatomical entity morphogenesis cellular component assembly axon ensheathment ensheathment of neurons anatomical structure formation involved in morphogenesis protein localization to cell periphery protein localization to plasma membrane localization within membrane protein localization to membrane morphogenesis of embryonic epithelium embryonic morphogenesis establishment or maintenance of cell polarity embryo development establishment or maintenance of polarity of embryonic epithelium head development forebrain development animal organ development brain development pallium development cerebral cortex development telencephalon development organic substance metabolic process biosynthetic process cellular biosynthetic process cellular metabolic process organic substance biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein localization to myelin sheath abaxonal region peripheral nervous system axon ensheathment glial cell development gliogenesis myelination in peripheral nervous system peripheral nervous system myelin maintenance Schwann cell differentiation peripheral nervous system development Schwann cell development glial cell differentiation myelin maintenance establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity membrane apical part of cell cell periphery plasma membrane plasma membrane region apical plasma membrane myelin sheath adaxonal region myelin sheath intracellular anatomical structure somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity membrane apical part of cell cell periphery plasma membrane plasma membrane region apical plasma membrane myelin sheath adaxonal region myelin sheath intracellular anatomical structure cytoplasm protein-containing complex cell-cell junction adherens junction anchoring junction cell junction membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system compact myelin Schmidt-Lanterman incisure apical junction complex bicellular tight junction tight junction axon cell projection neuron projection plasma membrane bounded cell projection lateral loop

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
A	IPR004172	L27 domain	Domain
A	IPR014775	L27 domain, C-terminal	Domain
A	IPR015145	L27-N	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR020590	Guanylate kinase, conserved site	Conserved Site
A	IPR035601	MPP5, SH3 domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR001452	SH3 domain	Domain
A	IPR036892	L27 domain superfamily	Homologous Superfamily
A	IPR008144	Guanylate kinase-like domain	Domain
A	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.