1UZQ
Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, apo form cbEGF23 domain only.
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1uzqa1 | Small proteins | Knottins (small inhibitors, toxins, lectins) | EGF/Laminin | EGF-type module | Fibrillin-1 | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d1uzqa3 | Small proteins | TB module/8-cys domain | TB module/8-cys domain | TB module/8-cys domain | Fibrillin | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | TB module/8-cys domain | 8035332 | 3000962 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | EGF/Laminin-like | 8035328 | 3000412 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | EGF/Laminin-like | 8035330 | 3000412 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF00683 | e1uzqA1 | A: few secondary structure elements | X: TB module/8-cys domain (From Topology) | H: TB module/8-cys domain (From Topology) | T: TB module/8-cys domain | F: PF00683 | ECOD (1.6) |
A | PF07645 | e1uzqA2 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF07645 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.10.25.10 | Mainly Beta | Ribbon | Laminin | Laminin | CATH (4.3.0) |
A | 3.90.290.10 | Alpha Beta | Alpha-Beta Complex | Extracellular Matrix Fibrillin | TGF-beta binding (TB) domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF07645 | Calcium-binding EGF domain (EGF_CA) | Calcium-binding EGF domain | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR024731 | EGF domain | Domain | |
IPR018097 | EGF-like calcium-binding, conserved site | Conserved Site | |
IPR026823 | Complement Clr-like EGF domain | Domain | |
IPR013032 | EGF-like, conserved site | Conserved Site | |
IPR000742 | EGF-like domain | Domain | |
IPR036773 | TGF-beta binding (TB) domain superfamily | Homologous Superfamily | |
IPR049388 | Fibrillin, first EGF domain | Domain | |
IPR009030 | Growth factor receptor cysteine-rich domain superfamily | Homologous Superfamily | |
IPR001881 | EGF-like calcium-binding domain | Domain | |
IPR017878 | TB domain | Domain | |
IPR000152 | EGF-type aspartate/asparagine hydroxylation site | PTM | |
IPR040872 | Fibrillin 1, unique N-terminal domain | Domain |