1UX5

Crystal Structures of a Formin Homology-2 domain reveal a flexibly tethered dimer architecture

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ux5a_	All alpha proteins	Formin homology 2 domain (FH2 domain)	Formin homology 2 domain (FH2 domain)	Formin homology 2 domain (FH2 domain)	Bni1	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Formin homology 2 domain (FH2 domain)	8022882	4000758	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Formin homology 2 domain (FH2 domain)	8035262	3001266	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02181	e1ux5A1	A: alpha complex topology	X: Formin homology 2 domain (FH2 domain) (From Topology)	H: Formin homology 2 domain (FH2 domain) (From Topology)	T: Formin homology 2 domain (FH2 domain)	F: PF02181	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.30.50	Special	Helix non-globular	Lyase 2-enoyl-coa Hydratase	Chain A, domain 2	CATH (4.3.0)
A	1.20.58.2220	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02181	Formin Homology 2 Domain (FH2)	Formin Homology 2 Domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	BNI1 PROTEIN	small GTPase binding protein binding binding enzyme binding GTPase binding profilin binding cytoskeletal protein binding actin binding identical protein binding	cellular component organization establishment or maintenance of actin cytoskeleton polarity organelle organization establishment or maintenance of cytoskeleton polarity actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis establishment or maintenance of cell polarity cytoskeleton organization actin filament organization actin nucleation supramolecular fiber organization regulation of cytoskeleton organization cellular component organization establishment or maintenance of actin cytoskeleton polarity organelle organization establishment or maintenance of cytoskeleton polarity actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis establishment or maintenance of cell polarity cytoskeleton organization actin filament organization actin nucleation supramolecular fiber organization regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process regulation of actin filament-based process biological regulation regulation of organelle organization regulation of actin cytoskeleton organization establishment of cell polarity reproductive process in single-celled organism reproductive process budding cell bud growth growth cell division budding cell apical bud growth cell budding asexual reproduction formin-nucleated actin cable assembly cellular component biogenesis parallel actin filament bundle assembly cellular component assembly actin filament bundle organization formin-nucleated actin cable organization actin filament bundle assembly establishment of organelle localization cellular localization microtubule cytoskeleton organization spindle localization mitotic cell cycle localization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of localization mitotic cell cycle process establishment of mitotic spindle orientation microtubule-based process assembly of actomyosin apparatus involved in cytokinesis mitotic actomyosin contractile ring assembly cytoskeleton-dependent cytokinesis mitotic cytokinetic process actomyosin contractile ring assembly mitotic cytokinesis cortical actin cytoskeleton organization assembly of actomyosin apparatus involved in mitotic cytokinesis actomyosin structure organization cortical cytoskeleton organization cytokinesis cytokinetic process actomyosin contractile ring organization protein localization regulation of localization regulation of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of cellular component size negative regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization actin filament capping negative regulation of supramolecular fiber organization regulation of biological quality negative regulation of actin filament polymerization cellular component disassembly barbed-end actin filament capping negative regulation of cellular component organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization actin polymerization or depolymerization protein polymerization regulation of actin filament organization actin filament polymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis negative regulation of organelle organization regulation of actin filament length negative regulation of actin filament depolymerization protein depolymerization regulation of anatomical structure size vesicle localization transport establishment of vesicle localization vesicle targeting vesicle-mediated transport	incipient cellular bud site cellular anatomical entity site of polarized growth cellular bud cellular bud tip cell projection mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection cell division site cell periphery plasma membrane incipient cellular bud site cellular anatomical entity site of polarized growth cellular bud cellular bud tip cell projection mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection cell division site cell periphery plasma membrane membrane polymeric cytoskeletal fiber intracellular anatomical structure actin filament actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle protein-containing complex polarisome cell cortex cytoplasm ascospore-type prospore prospore membrane intracellular immature spore cellular bud neck

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR042201	Formin, FH2 domain superfamily	Homologous Superfamily
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR015425	Formin, FH2 domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR014767	Diaphanous autoregulatory (DAD) domain	Domain
A	IPR010472	Formin, FH3 domain	Domain
A	IPR010473	Formin, GTPase-binding domain	Domain
A	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.