1UUG

ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH WILD-TYPE UDG AND WILD-TYPE UGI

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1uuga_	Alpha and beta proteins (a/b)	Uracil-DNA glycosylase-like	Uracil-DNA glycosylase-like	Uracil-DNA glycosylase	Uracil-DNA glycosylase	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d1uugc_	Alpha and beta proteins (a/b)	Uracil-DNA glycosylase-like	Uracil-DNA glycosylase-like	Uracil-DNA glycosylase	Uracil-DNA glycosylase	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d1uugb_	Alpha and beta proteins (a+b)	Cystatin-like	Uracil-DNA glycosylase inhibitor protein	Uracil-DNA glycosylase inhibitor protein	Uracil-DNA glycosylase inhibitor protein	(Bacillus phage PBS2 ) [TaxId: 10684 ],	SCOPe (2.08)
D	d1uugd_	Alpha and beta proteins (a+b)	Cystatin-like	Uracil-DNA glycosylase inhibitor protein	Uracil-DNA glycosylase inhibitor protein	Uracil-DNA glycosylase inhibitor protein	(Bacillus phage PBS2 ) [TaxId: 10684 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Uracil-DNA glycosylase-like	8044008	3001106	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Uracil-DNA glycosylase-like	8044008	3001106	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Uracil-DNA glycosylase inhibitor protein	8034693	3000500	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Uracil-DNA glycosylase inhibitor protein	8034693	3000500	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03167	e1uugA1	A: a/b three-layered sandwiches	X: Uracil-DNA glycosylase-like (From Topology)	H: Uracil-DNA glycosylase-like (From Topology)	T: Uracil-DNA glycosylase-like	F: PF03167	ECOD (1.6)
C	PF03167	e1uugC1	A: a/b three-layered sandwiches	X: Uracil-DNA glycosylase-like (From Topology)	H: Uracil-DNA glycosylase-like (From Topology)	T: Uracil-DNA glycosylase-like	F: PF03167	ECOD (1.6)
B	PF18880	e1uugB1	A: a+b two layers	X: Cystatin-like	H: Uracil-DNA glycosylase inhibitor protein (From Topology)	T: Uracil-DNA glycosylase inhibitor protein	F: PF18880	ECOD (1.6)
D	PF18880	e1uugD1	A: a+b two layers	X: Cystatin-like	H: Uracil-DNA glycosylase inhibitor protein (From Topology)	T: Uracil-DNA glycosylase inhibitor protein	F: PF18880	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.470.10	Alpha Beta	3-Layer(aba) Sandwich	Uracil-DNA Glycosylase, subunit E	Uracil-DNA glycosylase-like domain	CATH (4.3.0)
C	3.40.470.10	Alpha Beta	3-Layer(aba) Sandwich	Uracil-DNA Glycosylase, subunit E	Uracil-DNA glycosylase-like domain	CATH (4.3.0)
B	3.10.450.20	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.20	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF03167	Uracil DNA glycosylase superfamily (UDG)	Uracil DNA glycosylase superfamily	-	Domain
B, D	PF18880	Uracil-DNA glycosylase inhibitor (UDI)	Uracil-DNA glycosylase inhibitor	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	URACIL-DNA GLYCOSYLASE	uracil DNA N-glycosylase activity hydrolase activity, acting on glycosyl bonds deaminated base DNA N-glycosylase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid hydrolase activity DNA N-glycosylase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity	cellular response to stimulus response to stimulus base-excision repair, AP site formation via deaminated base removal primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process base-excision repair organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular response to stimulus response to stimulus base-excision repair, AP site formation via deaminated base removal primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process base-excision repair organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process base-excision repair, AP site formation DNA repair	intracellular anatomical structure cytoplasm cellular anatomical entity
B, D	URACIL-DNA GLYCOSYLASE INHIBITOR	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR002043	Uracil-DNA glycosylase family 1	Family
A, C	IPR018085	Uracil-DNA glycosylase, active site	Active Site
A, C	IPR036895	Uracil-DNA glycosylase-like domain superfamily	Homologous Superfamily
A, C	IPR005122	Uracil-DNA glycosylase-like	Domain
B, D	IPR024062	Bacteriophage PBS2, uracil-glycosylase inhibitor	Homologous Superfamily
B, D	IPR043805	Uracil-DNA glycosylase inhibitor	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.