1UTC

Clathrin terminal domain complexed with TLPWDLWTT

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1utca1	All alpha proteins	alpha-alpha superhelix	ARM repeat	Clathrin heavy-chain linker domain	Clathrin heavy-chain linker domain	BOVINE (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d1utca2	All beta proteins	7-bladed beta-propeller	Clathrin heavy-chain terminal domain	Clathrin heavy-chain terminal domain	Clathrin heavy-chain terminal domain	BOVINE (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1utcb1	All alpha proteins	alpha-alpha superhelix	ARM repeat	Clathrin heavy-chain linker domain	Clathrin heavy-chain linker domain	BOVINE (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1utcb2	All beta proteins	7-bladed beta-propeller	Clathrin heavy-chain terminal domain	Clathrin heavy-chain terminal domain	Clathrin heavy-chain terminal domain	BOVINE (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Clathrin heavy-chain linker domain	8029634	4001294	SCOP2 (2022-06-29)
A	SCOP2 Family	Clathrin heavy-chain terminal domain	8029635	4002756	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ARM repeat-like	8042013	3000116	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01394	e1utcA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01394	ECOD (1.6)
A	PF09268	e1utcA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09268	ECOD (1.6)
B	PF01394	e1utcB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01394	ECOD (1.6)
B	PF09268	e1utcB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09268	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.110	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	2.130.10.110	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF09268	Clathrin, heavy-chain linker (Clathrin-link)	Clathrin, heavy-chain linker	-	Repeat
A, B	PF01394	Clathrin propeller repeat (Clathrin_propel)	Clathrin propeller repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CLATHRIN HEAVY CHAIN	clathrin binding protein binding binding clathrin light chain binding protein domain specific binding arrestin family protein binding structural molecule activity disordered domain specific binding identical protein binding	cellular process cell cycle mitotic cell cycle cell division cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism cellular component disassembly clathrin coat disassembly transport protein-containing complex organization cellular process cell cycle mitotic cell cycle cell division cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism cellular component disassembly clathrin coat disassembly transport protein-containing complex organization protein-containing complex disassembly establishment of localization vesicle-mediated transport vesicle uncoating cellular component organization localization cellular component organization or biogenesis protein depolymerization protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport clathrin coat assembly cellular component biogenesis cellular component assembly protein-containing complex assembly regulation of cellular process negative regulation of biological process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance biosynthetic process glycosaminoglycan biosynthetic process negative regulation of carbohydrate metabolic process regulation of biological process negative regulation of metabolic process carbohydrate biosynthetic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process hyaluronan biosynthetic process biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process mucopolysaccharide metabolic process cellular biosynthetic process glycosaminoglycan metabolic process regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process negative regulation of hyaluronan biosynthetic process organic substance metabolic process hyaluronan metabolic process polysaccharide metabolic process negative regulation of cellular process regulation of carbohydrate metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process organonitrogen compound metabolic process polysaccharide biosynthetic process biological regulation regulation of macromolecule metabolic process macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan metabolic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process import into cell receptor-mediated endocytosis endocytosis	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex coated membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit clathrin coat of coated pit pigment granule intracellular vesicle melanosome cytoplasmic vesicle vesicle clathrin complex cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle clathrin-coated endocytic vesicle clathrin-coated vesicle coated vesicle endocytic vesicle vesicle coat transport vesicle membrane clathrin coat of trans-Golgi network vesicle bounding membrane of organelle trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle vesicle membrane clathrin vesicle coat Golgi-associated vesicle clathrin-coated vesicle membrane transport vesicle Golgi apparatus coated vesicle membrane cytoplasmic vesicle membrane Golgi-associated vesicle membrane organelle membrane
C [auth P], D [auth Q]	AMPHIPHYSIN	binding phospholipid binding lipid binding	synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis trans-synaptic signaling synaptic signaling regulation of biological process signaling anterograde trans-synaptic signaling biological regulation cell-cell signaling chemical synaptic transmission cell communication	intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle synapse intracellular vesicle transport vesicle membrane endomembrane system presynapse bounding membrane of organelle cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane intracellular membrane-bounded organelle cytoplasmic vesicle membrane secretory vesicle organelle membrane exocytic vesicle cell leading edge leading edge membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016341	Clathrin, heavy chain	Family
A, B	IPR015348	Clathrin, heavy chain, linker, core motif	Domain
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B	IPR016025	Clathrin heavy chain, N-terminal	Homologous Superfamily
A, B	IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat	Repeat
A, B	IPR022365	Clathrin, heavy chain, propeller repeat	Repeat
C [auth P], D [auth Q]	IPR004148	BAR domain	Domain
C [auth P], D [auth Q]	IPR035470	Amphiphysin I, SH3 domain	Domain
C [auth P], D [auth Q]	IPR001452	SH3 domain	Domain
C [auth P], D [auth Q]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
C [auth P], D [auth Q]	IPR003005	Amphiphysin	Family
C [auth P], D [auth Q]	IPR027267	AH/BAR domain superfamily	Homologous Superfamily
C [auth P], D [auth Q]	IPR003017	Amphiphysin, isoform 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth P], D [auth Q]	Pharos: P49418	astrocytic tumor cystic fibrosis large cell medulloblastoma malignant glioma osteosarcoma psoriasis atypical teratoid rhabdoid tumor encephalitis lung carcinoma medulloblastoma pilocytic astrocytoma subependymal giant cell astrocytoma breast cancer glioblastoma malignant ependymoma astrocytic tumor cystic fibrosis large cell medulloblastoma malignant glioma osteosarcoma psoriasis atypical teratoid rhabdoid tumor encephalitis lung carcinoma medulloblastoma pilocytic astrocytoma subependymal giant cell astrocytoma breast cancer glioblastoma malignant ependymoma oligodendroglioma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.