1UNL

Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1unla_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Cyclin-dependent PK, CDK5	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1unlb_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Cyclin-dependent PK, CDK5	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth D]	d1unld_	All alpha proteins	Cyclin-like	Cyclin-like	Cyclin	CDK5 activator 1 (NCK5a, p25)	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth E]	d1unle_	All alpha proteins	Cyclin-like	Cyclin-like	Cyclin	CDK5 activator 1 (NCK5a, p25)	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Protein kinases catalytic domain-like	8030505	4003661	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Protein kinase-like (PK-like)	8042884	3000066	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Protein kinase-like (PK-like)	8042884	3000066	SCOP2B (2022-06-29)
C [auth D]	SCOP2 Family	Cyclin	8030506	4001102	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Superfamily	Cyclin-like	8042885	3000768	SCOP2 (2022-06-29)
D [auth E]	SCOP2B Superfamily	Cyclin-like	8042885	3000768	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e1unlA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
B	Pkinase_Tyr	e1unlB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
C [auth D]	CDK5_activator	e1unlD1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: CDK5_activator	ECOD (1.6)
D [auth E]	CDK5_activator	e1unlE1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: CDK5_activator	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
B	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
C [auth D]	1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)
D [auth E]	1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain
C [auth D], D [auth E]	PF03261	Cyclin-dependent kinase 5 activator protein (CDK5_activator)	Cyclin-dependent kinase 5 activator protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CYCLIN-DEPENDENT KINASE 5	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein binding signaling receptor binding ErbB-3 class receptor binding tau-protein kinase activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase activity cytoskeletal protein binding tau protein binding neurotransmitter receptor regulator activity acetylcholine receptor regulator activity acetylcholine receptor activator activity molecular function activator activity molecular function regulator activity signaling receptor regulator activity signaling receptor activator activity p53 binding ErbB-2 class receptor binding Hsp90 protein binding heat shock protein binding protein serine kinase activity	regulation of biological process catabolic process regulation of cellular process macroautophagy cellular metabolic process biological regulation autophagy regulation of cellular metabolic process regulation of catabolic process regulation of autophagy cellular catabolic process regulation of macroautophagy regulation of cellular catabolic process metabolic process regulation of biological process catabolic process regulation of cellular process macroautophagy cellular metabolic process biological regulation autophagy regulation of cellular metabolic process regulation of catabolic process regulation of autophagy cellular catabolic process regulation of macroautophagy regulation of cellular catabolic process metabolic process cellular process regulation of metabolic process process utilizing autophagic mechanism axon extension multicellular organismal process regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization negative regulation of biological process regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development multicellular organism development cell projection morphogenesis neuron differentiation negative regulation of growth neuron projection morphogenesis cell differentiation anatomical structure development regulation of biological quality system development developmental process negative regulation of cellular component organization regulation of cell projection organization negative regulation of cell growth nervous system development developmental growth involved in morphogenesis generation of neurons negative regulation of axonogenesis negative regulation of developmental growth negative regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension cellular component organization regulation of nervous system development neurogenesis negative regulation of neurogenesis regulation of extent of cell growth regulation of axonogenesis negative regulation of cellular process negative regulation of nervous system development regulation of multicellular organismal process negative regulation of cell differentiation cellular component organization or biogenesis negative regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth negative regulation of developmental process growth negative regulation of axon extension axon development regulation of cell growth cell morphogenesis involved in neuron differentiation negative regulation of neuron projection development anatomical structure morphogenesis negative regulation of cell development neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size cell division vesicle localization establishment of organelle localization cellular localization transport establishment of vesicle localization establishment of localization localization organelle localization establishment of localization in cell synaptic vesicle localization synaptic vesicle transport regulation of localization regulated exocytosis regulation of calcium ion-dependent exocytosis positive regulation of biological process positive regulation of secretion by cell vesicle-mediated transport positive regulation of exocytosis regulation of regulated secretory pathway secretion by cell regulation of secretion by cell positive regulation of secretion positive regulation of regulated secretory pathway positive regulation of cellular process calcium-ion regulated exocytosis positive regulation of calcium ion-dependent exocytosis secretion regulation of transport export from cell regulation of vesicle-mediated transport regulation of secretion exocytosis positive regulation of transport regulation of exocytosis protein phosphorylation organonitrogen compound metabolic process phosphorylation primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process trans-synaptic signaling synaptic signaling signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission cell communication protein localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane receptor clustering corpus callosum development head development forebrain development animal organ development brain development central nervous system development telencephalon development negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of synapse structure or activity dendritic spine morphogenesis synapse organization dendritic spine development dendritic spine organization postsynapse organization regulation of postsynapse organization dendrite development dendrite morphogenesis regulation of synapse organization cell junction organization regulation of dendritic spine morphogenesis neuron projection organization protein localization to synapse protein localization to cell junction negative regulation of proteolysis regulation of protein metabolic process regulation of proteolysis proteolysis negative regulation of protein metabolic process cell cycle cellular response to stimulus regulation of postsynaptic membrane potential system process response to stimulus chemical synaptic transmission, postsynaptic signal transduction cell surface receptor signaling pathway nervous system process excitatory postsynaptic potential regulation of membrane potential neuron apoptotic process apoptotic process cell death programmed cell death organelle organization microtubule cytoskeleton organization microtubule-based process cytoskeleton organization sensory perception sensory perception of pain cellular response to nitrogen compound response to organic substance response to organonitrogen compound response to endogenous stimulus response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to organic substance response to amyloid-beta glial cell migration telencephalon glial cell migration cerebral cortex development telencephalon cell migration forebrain cell migration gliogenesis cell migration cell motility layer formation in cerebral cortex cerebral cortex cell migration cerebral cortex radially oriented cell migration pallium development anatomical structure formation involved in morphogenesis cerebral cortex radial glia-guided migration central nervous system neuron development central nervous system neuron differentiation negative regulation of protein transport establishment of protein localization negative regulation of nucleocytoplasmic transport nitrogen compound transport nucleocytoplasmic transport nuclear transport negative regulation of intracellular protein transport negative regulation of transport nuclear export regulation of protein export from nucleus regulation of intracellular transport organic substance transport negative regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus protein export from nucleus maintenance of location regulation of intracellular protein transport intracellular protein transport maintenance of protein location maintenance of location in cell maintenance of protein location in cell negative regulation of protein export from nucleus negative regulation of protein localization negative regulation of intracellular transport regulation of establishment of protein localization maintenance of protein location in nucleus regulation of protein transport protein transport protein localization to organelle maintenance of protein localization in organelle negative regulation of post-translational protein modification regulation of protein modification process regulation of protein ubiquitination protein ubiquitination negative regulation of protein modification process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of synaptic plasticity regulation of signaling modulation of chemical synaptic transmission negative regulation of synaptic plasticity regulation of trans-synaptic signaling regulation of cell communication negative regulation of cell cycle regulation of cell cycle positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process peptidyl-amino acid modification peptidyl-threonine modification peptidyl-threonine phosphorylation regulation of cell motility regulation of locomotion regulation of cell migration locomotion synaptic transmission, dopaminergic monoatomic ion transport calcium ion import monoatomic cation transport calcium ion transport metal ion transport peptidyl-serine modification peptidyl-serine phosphorylation cerebellum morphogenesis cerebellar cortex morphogenesis hindbrain morphogenesis cerebellar cortex development cerebellum development metencephalon development cerebellar cortex formation hindbrain development synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse signal release neurotransmitter secretion neurotransmitter transport signal release from synapse cellular component biogenesis cellular component assembly cell junction assembly synapse assembly protein targeting positive regulation of establishment of protein localization regulation of protein targeting to membrane establishment of protein localization to membrane positive regulation of protein localization to membrane protein targeting to membrane regulation of protein targeting positive regulation of protein localization positive regulation of protein targeting to membrane receptor catabolic process macromolecule catabolic process receptor metabolic process organic substance catabolic process cell adhesion cell-matrix adhesion cell-substrate adhesion hippocampus development limbic system development synaptic vesicle endocytosis import into cell presynaptic endocytosis synaptic vesicle recycling endocytosis adult behavior response to alkaloid behavior behavioral response to cocaine response to organic cyclic compound response to cocaine oligodendrocyte differentiation glial cell differentiation peripheral nervous system development glial cell development Schwann cell development Schwann cell differentiation motor neuron axon guidance axon guidance neuron projection guidance muscle structure development skeletal muscle organ development skeletal muscle tissue development muscle tissue development muscle organ development tissue development regulation of synaptic vesicle recycling response to light stimulus learning learning or memory visual learning visual behavior cognition associative learning response to radiation response to abiotic stimulus rhythmic process neuron migration synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity intracellular anatomical structure cytoplasm cytosol neuromuscular junction synapse cell junction protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity intracellular anatomical structure cytoplasm cytosol neuromuscular junction synapse cell junction protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex protein kinase 5 complex cell periphery plasma membrane membrane cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cyclin-dependent protein kinase holoenzyme complex dendrite dendritic tree neuron projection axon actin-based cell projection filopodium presynapse growth cone distal axon site of polarized growth membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse
C [auth D], D [auth E]	CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding tubulin binding alpha-tubulin binding cell adhesion molecule binding cadherin binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding tubulin binding alpha-tubulin binding cell adhesion molecule binding cadherin binding catalytic activity, acting on a protein protein kinase activity phosphotransferase activity, alcohol group as acceptor signaling receptor binding ephrin receptor binding enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity cation binding ion binding calcium ion binding metal ion binding small molecule binding enzyme binding protease binding cyclin-dependent protein serine/threonine kinase activator activity cyclin-dependent protein serine/threonine kinase regulator activity ionotropic glutamate receptor binding glutamate receptor binding kinase binding protein kinase binding beta-tubulin binding	developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular developmental process forebrain development glial cell migration telencephalon glial cell migration developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular developmental process forebrain development glial cell migration telencephalon glial cell migration cerebral cortex development neurogenesis telencephalon cell migration forebrain cell migration gliogenesis cell differentiation cell migration cell motility layer formation in cerebral cortex cerebral cortex cell migration cerebral cortex radially oriented cell migration pallium development anatomical structure morphogenesis anatomical structure formation involved in morphogenesis cellular process cerebral cortex radial glia-guided migration telencephalon development regulation of biological process catabolic process regulation of cellular process macroautophagy cellular metabolic process biological regulation autophagy regulation of cellular metabolic process regulation of catabolic process regulation of autophagy cellular catabolic process regulation of macroautophagy regulation of cellular catabolic process metabolic process regulation of metabolic process process utilizing autophagic mechanism cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway neuron apoptotic process positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process positive regulation of neuron apoptotic process programmed cell death positive regulation of cellular process regulation of neuron apoptotic process organonitrogen compound metabolic process protein phosphorylation phosphorylation primary metabolic process organic substance metabolic process macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation cerebellum development metencephalon development hindbrain development cell adhesion cell-cell adhesion neuron cell-cell adhesion peptidyl-serine modification peptidyl-serine phosphorylation positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization positive regulation of cellular component organization microtubule cytoskeleton organization cellular component organization cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly microtubule polymerization or depolymerization positive regulation of protein polymerization protein-containing complex assembly cellular component organization or biogenesis protein polymerization positive regulation of microtubule polymerization or depolymerization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization regulation of microtubule-based process microtubule polymerization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis regulation of organelle organization organelle organization positive regulation of microtubule polymerization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization microtubule-based process supramolecular fiber organization cytoskeleton organization regulation of microtubule cytoskeleton organization neuron recognition cell projection organization cell development neuron projection development neuron projection fasciculation neuron differentiation axonal fasciculation cell recognition plasma membrane bounded cell projection organization axon development generation of neurons neuron development G1 to G0 transition involved in cell differentiation cell cycle G1 to G0 transition cell cycle process regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of cyclin-dependent protein kinase activity regulation of transferase activity regulation of primary metabolic process regulation of cyclin-dependent protein serine/threonine kinase activity regulation of phosphate metabolic process regulation of cell cycle regulation of protein metabolic process regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorylation regulation of phosphorus metabolic process regulation of localization cellular localization transport regulation of transport regulation of synaptic vesicle cycle synaptic vesicle cycle regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse localization establishment of localization in cell protein localization establishment of protein localization regulation of protein localization protein targeting positive regulation of establishment of protein localization regulation of protein targeting to membrane cellular macromolecule localization regulation of protein localization to membrane establishment of protein localization to membrane regulation of establishment of protein localization positive regulation of protein localization to membrane localization within membrane protein localization to membrane protein targeting to membrane regulation of cellular localization regulation of protein targeting macromolecule localization positive regulation of protein localization positive regulation of protein targeting to membrane negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process hippocampus development limbic system development cell projection morphogenesis neuron projection morphogenesis regulation of synapse structure or activity dendritic spine morphogenesis synapse organization regulation of biological quality dendritic spine development dendritic spine organization postsynapse organization regulation of cell projection organization regulation of postsynapse organization regulation of neuron projection development regulation of developmental process plasma membrane bounded cell projection morphogenesis cell morphogenesis dendrite development regulation of anatomical structure morphogenesis dendrite morphogenesis cell morphogenesis involved in neuron differentiation regulation of synapse organization cell junction organization regulation of dendritic spine morphogenesis neuron projection organization regulation of plasma membrane bounded cell projection organization superior olivary nucleus development pons development hindbrain maturation central nervous system maturation pons maturation developmental maturation superior olivary nucleus maturation anatomical structure maturation neural nucleus development regulation of actin filament-based process actin cytoskeleton organization regulation of actin cytoskeleton organization actin filament-based process regulation of cell differentiation regulation of neuron differentiation rhythmic process axonogenesis axon guidance neuron projection guidance ligand-gated ion channel signaling pathway ionotropic glutamate receptor signaling pathway glutamate receptor signaling pathway neuron migration cellular response to nitrogen compound response to organic substance synaptic signaling cellular response to acetylcholine response to oxygen-containing compound cell-cell signaling response to nitrogen compound acetylcholine receptor signaling pathway postsynaptic signal transduction cellular response to oxygen-containing compound cellular response to chemical stimulus G protein-coupled acetylcholine receptor signaling pathway response to chemical response to acetylcholine G protein-coupled receptor signaling pathway embryo development ending in birth or egg hatching embryo development	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex membrane intracellular anatomical structure somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex membrane intracellular anatomical structure cytoplasm cytosol cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection neuromuscular junction synapse cell junction intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle neuron spine dendritic spine postsynapse perinuclear region of cytoplasm axon protein kinase 5 complex cell periphery plasma membrane membrane-bounded organelle intracellular membrane-bounded organelle presynapse growth cone distal axon site of polarized growth nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR008271	Serine/threonine-protein kinase, active site	Active Site
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
C [auth D], D [auth E]	IPR004944	Cyclin-dependent kinase 5 activator	Family
C [auth D], D [auth E]	IPR036915	Cyclin-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q00535	lissencephaly 7 with cerebellar hypoplasia tauopathy lissencephaly spectrum disorders malignant mesothelioma myocardial infarction peripheral nervous system disease pilocytic astrocytoma tuberculosis allergic rhinitis atrial fibrillation Cerebellar Hypoplasia glioblastoma large cell medulloblastoma lung cancer malignant ependymoma lissencephaly 7 with cerebellar hypoplasia tauopathy lissencephaly spectrum disorders malignant mesothelioma myocardial infarction peripheral nervous system disease pilocytic astrocytoma tuberculosis allergic rhinitis atrial fibrillation Cerebellar Hypoplasia glioblastoma large cell medulloblastoma lung cancer malignant ependymoma medulloblastoma neurodegenerative disease peripheral neuropathy schizophrenia Alzheimer disease atypical teratoid rhabdoid tumor cerebrovascular disorder hypertensive disorder lung carcinoma malignant glioma metabolic syndrome X oligodendroglioma Pick disease astrocytic tumor breast cancer cocaine dependence invasive ductal breast carcinoma malignant colon neoplasm
C [auth D], D [auth E]	Pharos: Q15078	Nerve Degeneration brain disease pituitary cancer schizophrenia astrocytic tumor atypical teratoid rhabdoid tumor cutaneous lupus erythematosus intellectual disability malignant ependymoma osteosarcoma psoriasis Sjogren syndrome atopic eczema esophageal adenocarcinoma lung cancer Nerve Degeneration brain disease pituitary cancer schizophrenia astrocytic tumor atypical teratoid rhabdoid tumor cutaneous lupus erythematosus intellectual disability malignant ependymoma osteosarcoma psoriasis Sjogren syndrome atopic eczema esophageal adenocarcinoma lung cancer malignant glioma non-small cell lung carcinoma pilocytic astrocytoma sarcoidosis tuberculosis attention deficit hyperactivity disorder, inattentive type glioblastoma malignant colon neoplasm medulloblastoma oligodendroglioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.