1UJY

Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ujya1	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	Rac/CDC42 GEF 6	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1ujya3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1ujya2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SH3-domain	8018889	4000369	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SH3-domain	8057935	3000153	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_1	e1ujyA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07653	Variant SH3 domain (SH3_2)	Variant SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain
A	PF16615	Unstructured region one on RhoGEF 6 and 7 (RhoGEF67_u1)	Unstructured region one on RhoGEF 6 and 7	-	Disordered

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Rho guanine nucleotide exchange factor 6	GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity enzyme activator activity GTPase activator activity molecular function activator activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication JNK cascade intracellular signaling cassette MAPK cascade cellular process signal transduction lamellipodium assembly cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication JNK cascade intracellular signaling cassette MAPK cascade cellular process signal transduction lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular component organization or biogenesis cell projection assembly apoptotic process cell death programmed cell death	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003096	Smooth muscle protein/calponin	Family
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR000219	Dbl homology (DH) domain	Domain
A	IPR001452	SH3 domain	Domain
A	IPR036872	CH domain superfamily	Homologous Superfamily
A	IPR001715	Calponin homology domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A	IPR032409	Rho guanine nucleotide exchange factor 6/7, coiled-coil domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR046376	RhoGEF 6/7, PH domain	Domain
A	IPR035788	Rho guanine nucleotide exchange factor 6, SH3 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q15052	intellectual disability, X-linked 46 intellectual disability oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm subependymal giant cell astrocytoma astrocytic tumor ductal breast carcinoma in situ lung adenocarcinoma lymphoplasmacytic lymphoma medulloblastoma non-small cell lung carcinoma ovarian cancer pilocytic astrocytoma tuberculosis breast cancer intellectual disability, X-linked 46 intellectual disability oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm subependymal giant cell astrocytoma astrocytic tumor ductal breast carcinoma in situ lung adenocarcinoma lymphoplasmacytic lymphoma medulloblastoma non-small cell lung carcinoma ovarian cancer pilocytic astrocytoma tuberculosis breast cancer glioblastoma invasive ductal breast carcinoma lung cancer malignant colon neoplasm Mental Retardation, X-Linked 1 non-syndromic X-linked intellectual disability pancreatic intraductal papillary-mucinous carcinoma psoriasis ulcerative colitis cystic fibrosis large cell medulloblastoma lung carcinoma malignant glioma myopathy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.