1UEF

Crystal Structure of Dok1 PTB Domain Complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1uefa1	All beta proteins	PH domain-like barrel	PH domain-like	Phosphotyrosine-binding domain (PTB)	Docking protein 1, Dok1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1uefa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1uefb_	All beta proteins	PH domain-like barrel	PH domain-like	Phosphotyrosine-binding domain (PTB)	Docking protein 1, Dok1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PH domain-like	8038247	3000134	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PH domain-like	8038247	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02174	e1uefA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF02174	ECOD (1.6)
B	PF02174	e1uefB1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF02174	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
B	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02174	PTB domain (IRS-1 type) (IRS)	PTB domain (IRS-1 type)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, D	13-mer peptide from Proto-oncogene tyrosine-protein kinase receptor ret	molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding calcium ion binding metal ion binding	response to stimulus response to chemical response to xenobiotic stimulus regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process developmental process multicellular organismal process morphogenesis of embryonic epithelium embryonic epithelial tube formation epithelium development response to stimulus response to chemical response to xenobiotic stimulus regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process developmental process multicellular organismal process morphogenesis of embryonic epithelium embryonic epithelial tube formation epithelium development tube development embryonic morphogenesis morphogenesis of an epithelium tube formation tissue development embryo development epithelial tube formation tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis epithelial tube morphogenesis cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction signal transduction in absence of ligand signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand signal transduction positive regulation of cellular process regulation of signaling positive regulation of programmed cell death cell surface receptor signaling pathway regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process sensory organ development eye development animal organ development retina development in camera-type eye visual system development camera-type eye development sensory system development system development positive regulation of metanephric glomerulus development regulation of developmental process metanephric glomerulus development regulation of kidney development renal system development positive regulation of developmental process metanephros development regulation of glomerulus development regulation of multicellular organismal process nephron development metanephric nephron development regulation of metanephric glomerulus development positive regulation of glomerulus development positive regulation of kidney development glomerulus development positive regulation of multicellular organismal process regulation of metanephros development kidney development positive regulation of metanephros development organonitrogen compound metabolic process proteolysis membrane protein proteolysis primary metabolic process protein metabolic process response to organic substance response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to chemical stimulus cellular response to retinoic acid cellular response to lipid cellular response to organic substance ureter development developmental maturation ureter maturation anatomical structure maturation animal organ maturation intracellular signal transduction intracellular signaling cassette MAPK cascade regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process cell projection organization cell development neuron projection development cellular component organization neurogenesis neuron differentiation positive regulation of neuron projection development cell differentiation positive regulation of cell projection organization cellular component organization or biogenesis plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization cell-cell adhesion neuron cell-cell adhesion phosphorylation phosphate-containing compound metabolic process phosphorus metabolic process cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules regulation of cell differentiation positive regulation of cell maturation regulation of neuron maturation regulation of cell development positive regulation of cell differentiation cell maturation regulation of cell maturation positive regulation of neuron maturation positive regulation of cell development neuron maturation regulation of neuron differentiation response to stress multicellular organismal response to stress response to pain immune system development hematopoietic or lymphoid organ development Peyer's patch morphogenesis Peyer's patch development mucosa-associated lymphoid tissue development immune system process axonogenesis plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis regulation of axonogenesis regulation of anatomical structure morphogenesis axon development cell morphogenesis involved in neuron differentiation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of intracellular signal transduction positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction stem cell development neural crest cell differentiation neural crest cell development mesenchyme development mesenchymal cell migration stem cell differentiation ameboidal-type cell migration cell migration mesenchymal cell differentiation cell motility neural crest cell migration positive regulation of cell adhesion mediated by integrin positive regulation of cell adhesion regulation of cell adhesion mediated by integrin cell adhesion mediated by integrin ureteric bud development mesonephric epithelium development kidney epithelium development mesonephros development mesonephric tubule development positive regulation of MAPK cascade regulation of MAPK cascade positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion cell surface receptor protein tyrosine kinase signaling pathway glial cell-derived neurotrophic factor receptor signaling pathway enzyme-linked receptor protein signaling pathway regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process enteric nervous system development autonomic nervous system development positive regulation of cell size regulation of cellular component size regulation of biological quality regulation of cell size regulation of anatomical structure size nerve development innervation positive regulation of phosphorylation regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification regulation of receptor signaling pathway via JAK-STAT protein modification process positive regulation of protein phosphorylation positive regulation of peptidyl-serine phosphorylation of STAT protein protein phosphorylation positive regulation of phosphorus metabolic process regulation of protein metabolic process serine phosphorylation of STAT protein macromolecule modification regulation of phosphorus metabolic process regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation of STAT protein peptidyl-serine modification positive regulation of protein modification process peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation regulation of phosphorylation cell surface receptor signaling pathway via JAK-STAT	somatodendritic compartment cell projection dendrite dendritic tree neuron projection cellular anatomical entity plasma membrane bounded cell projection protein-containing complex receptor complex cell periphery plasma membrane protein complex membrane plasma membrane membrane protein complex somatodendritic compartment cell projection dendrite dendritic tree neuron projection cellular anatomical entity plasma membrane bounded cell projection protein-containing complex receptor complex cell periphery plasma membrane protein complex membrane plasma membrane membrane protein complex endosome membrane membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane cell body neuronal cell body axon early endosome
A, B	Docking protein 1	-	cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation regulation of MAPK cascade negative regulation of signal transduction regulation of response to stimulus MAPK cascade regulation of cell communication cellular process negative regulation of MAPK cascade positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of response to stimulus positive regulation of cellular process positive regulation of MAPK cascade positive regulation of intracellular signal transduction positive regulation of signaling response to organic substance cell surface receptor signaling pathway response to cytokine macrophage colony-stimulating factor signaling pathway response to macrophage colony-stimulating factor cytokine-mediated signaling pathway cellular response to macrophage colony-stimulating factor stimulus cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway small GTPase-mediated signal transduction Ras protein signal transduction	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, D	IPR008266	Tyrosine-protein kinase, active site	Active Site
C, D	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
C, D	IPR015919	Cadherin-like superfamily	Homologous Superfamily
C, D	IPR041317	RET, cadherin-like domain 4	Domain
C, D	IPR016249	Tyrosine-protein kinase, Ret receptor	Family
C, D	IPR000719	Protein kinase domain	Domain
C, D	IPR041163	Ret, cadherin like domain 1	Domain
C, D	IPR002126	Cadherin-like	Domain
C, D	IPR017441	Protein kinase, ATP binding site	Binding Site
C, D	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
C, D	IPR040667	Tyrosine-protein kinase receptor Ret, cadherin like domain 3	Domain
C, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR001849	Pleckstrin homology domain	Domain
A, B	IPR002404	IRS-type PTB domain	Domain
A, B	IPR037751	Dok1/2/3, PTB domain	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C, D	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.