Annotations: 1UDY

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1udya1	All alpha proteins	Bromodomain-like	Acyl-CoA dehydrogenase C-terminal domain-like	Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	Medium chain acyl-CoA dehydrogenase, C-domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d1udya2	Multi-domain proteins (alpha and beta)	Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase NM domain-like	Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	Medium chain acyl-CoA dehydrogenase, NM domains	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
B	d1udyb1	All alpha proteins	Bromodomain-like	Acyl-CoA dehydrogenase C-terminal domain-like	Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	Medium chain acyl-CoA dehydrogenase, C-domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
B	d1udyb2	Multi-domain proteins (alpha and beta)	Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase NM domain-like	Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	Medium chain acyl-CoA dehydrogenase, NM domains	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
D	d1udyd1	All alpha proteins	Bromodomain-like	Acyl-CoA dehydrogenase C-terminal domain-like	Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	Medium chain acyl-CoA dehydrogenase, C-domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
D	d1udyd2	Multi-domain proteins (alpha and beta)	Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase NM domain-like	Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	Medium chain acyl-CoA dehydrogenase, NM domains	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
C	d1udyc1	All alpha proteins	Bromodomain-like	Acyl-CoA dehydrogenase C-terminal domain-like	Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	Medium chain acyl-CoA dehydrogenase, C-domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
C	d1udyc2	Multi-domain proteins (alpha and beta)	Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase NM domain-like	Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	Medium chain acyl-CoA dehydrogenase, NM domains	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Acyl-CoA dehydrogenase N-terminal lobe-like	8037423	3001701	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Acyl-CoA dehydrogenase C-terminal domain-like	8036927	3001580	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Acyl-CoA dehydrogenase N-terminal lobe-like	8037423	3001701	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Acyl-CoA dehydrogenase C-terminal domain-like	8036927	3001580	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Acyl-CoA dehydrogenase C-terminal domain-like	8036927	3001580	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Acyl-CoA dehydrogenase N-terminal lobe-like	8037423	3001701	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Acyl-CoA dehydrogenase N-terminal lobe-like	8037423	3001701	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Acyl-CoA dehydrogenase C-terminal domain-like	8036927	3001580	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Acyl-CoA_dh_M	e1udyA1	A: beta complex topology	X: Acyl-CoA dehydrogenase middle domain-like (From Topology)	H: Acyl-CoA dehydrogenase middle domain-like (From Topology)	T: Acyl-CoA dehydrogenase middle domain-like	F: Acyl-CoA_dh_M	ECOD (1.6)
A	Acyl-CoA_dh_N	e1udyA2	A: alpha arrays	X: Acyl-CoA dehydrogenase N-terminal domain-like (From Topology)	H: Acyl-CoA dehydrogenase N-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase N-terminal domain-like	F: Acyl-CoA_dh_N	ECOD (1.6)
A	Acyl-CoA_dh_1	e1udyA3	A: alpha bundles	X: Bromodomain-like	H: Acyl-CoA dehydrogenase C-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase C-terminal domain-like	F: Acyl-CoA_dh_1	ECOD (1.6)
B	Acyl-CoA_dh_M	e1udyB1	A: beta complex topology	X: Acyl-CoA dehydrogenase middle domain-like (From Topology)	H: Acyl-CoA dehydrogenase middle domain-like (From Topology)	T: Acyl-CoA dehydrogenase middle domain-like	F: Acyl-CoA_dh_M	ECOD (1.6)
B	Acyl-CoA_dh_N	e1udyB2	A: alpha arrays	X: Acyl-CoA dehydrogenase N-terminal domain-like (From Topology)	H: Acyl-CoA dehydrogenase N-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase N-terminal domain-like	F: Acyl-CoA_dh_N	ECOD (1.6)
B	Acyl-CoA_dh_1	e1udyB3	A: alpha bundles	X: Bromodomain-like	H: Acyl-CoA dehydrogenase C-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase C-terminal domain-like	F: Acyl-CoA_dh_1	ECOD (1.6)
D	Acyl-CoA_dh_M	e1udyD1	A: beta complex topology	X: Acyl-CoA dehydrogenase middle domain-like (From Topology)	H: Acyl-CoA dehydrogenase middle domain-like (From Topology)	T: Acyl-CoA dehydrogenase middle domain-like	F: Acyl-CoA_dh_M	ECOD (1.6)
D	Acyl-CoA_dh_N	e1udyD2	A: alpha arrays	X: Acyl-CoA dehydrogenase N-terminal domain-like (From Topology)	H: Acyl-CoA dehydrogenase N-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase N-terminal domain-like	F: Acyl-CoA_dh_N	ECOD (1.6)
D	Acyl-CoA_dh_1	e1udyD3	A: alpha bundles	X: Bromodomain-like	H: Acyl-CoA dehydrogenase C-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase C-terminal domain-like	F: Acyl-CoA_dh_1	ECOD (1.6)
C	Acyl-CoA_dh_M	e1udyC1	A: beta complex topology	X: Acyl-CoA dehydrogenase middle domain-like (From Topology)	H: Acyl-CoA dehydrogenase middle domain-like (From Topology)	T: Acyl-CoA dehydrogenase middle domain-like	F: Acyl-CoA_dh_M	ECOD (1.6)
C	Acyl-CoA_dh_N	e1udyC2	A: alpha arrays	X: Acyl-CoA dehydrogenase N-terminal domain-like (From Topology)	H: Acyl-CoA dehydrogenase N-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase N-terminal domain-like	F: Acyl-CoA_dh_N	ECOD (1.6)
C	Acyl-CoA_dh_1	e1udyC3	A: alpha bundles	X: Bromodomain-like	H: Acyl-CoA dehydrogenase C-terminal domain-like (From Topology)	T: Acyl-CoA dehydrogenase C-terminal domain-like	F: Acyl-CoA_dh_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.540.10	Mainly Alpha	Orthogonal Bundle	Butyryl-Coa Dehydrogenase, subunit A	domain 1	CATH (4.3.0)
A	2.40.110.10	Mainly Beta	Beta Barrel	Butyryl-CoA Dehydrogenase, subunit A	domain 2	CATH (4.3.0)
A	1.20.140.10	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)
B	1.10.540.10	Mainly Alpha	Orthogonal Bundle	Butyryl-Coa Dehydrogenase, subunit A	domain 1	CATH (4.3.0)
B	2.40.110.10	Mainly Beta	Beta Barrel	Butyryl-CoA Dehydrogenase, subunit A	domain 2	CATH (4.3.0)
B	1.20.140.10	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)
D	1.10.540.10	Mainly Alpha	Orthogonal Bundle	Butyryl-Coa Dehydrogenase, subunit A	domain 1	CATH (4.3.0)
D	2.40.110.10	Mainly Beta	Beta Barrel	Butyryl-CoA Dehydrogenase, subunit A	domain 2	CATH (4.3.0)
D	1.20.140.10	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)
C	1.10.540.10	Mainly Alpha	Orthogonal Bundle	Butyryl-Coa Dehydrogenase, subunit A	domain 1	CATH (4.3.0)
C	2.40.110.10	Mainly Beta	Beta Barrel	Butyryl-CoA Dehydrogenase, subunit A	domain 2	CATH (4.3.0)
C	1.20.140.10	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02771	Acyl-CoA dehydrogenase, N-terminal domain (Acyl-CoA_dh_N)	Acyl-CoA dehydrogenase, N-terminal domain	The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha domain.	Domain
A, B, C, D	PF02770	Acyl-CoA dehydrogenase, middle domain (Acyl-CoA_dh_M)	Acyl-CoA dehydrogenase, middle domain	Central domain of Acyl-CoA dehydrogenase has a beta-barrel fold.	Domain
A, B, C, D	PF00441	Acyl-CoA dehydrogenase, C-terminal domain (Acyl-CoA_dh_1)	Acyl-CoA dehydrogenase, C-terminal domain	C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Acyl-CoA dehydrogenase, medium-chain specific	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor oxidoreductase activity acyl-CoA dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor oxidoreductase activity acyl-CoA dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding medium-chain fatty acyl-CoA dehydrogenase activity identical protein binding protein binding	developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development monosaccharide metabolic process gluconeogenesis regulation of primary metabolic process organic substance metabolic process regulation of small molecule metabolic process developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development monosaccharide metabolic process gluconeogenesis regulation of primary metabolic process organic substance metabolic process regulation of small molecule metabolic process organic substance biosynthetic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process regulation of biosynthetic process carbohydrate metabolic process regulation of biological process small molecule biosynthetic process carbohydrate biosynthetic process biological regulation hexose metabolic process primary metabolic process monosaccharide biosynthetic process hexose biosynthetic process biosynthetic process regulation of gluconeogenesis metabolic process regulation of carbohydrate biosynthetic process regulation of metabolic process glucose metabolic process response to stimulus response to stress response to abiotic stimulus response to cold response to temperature stimulus carnitine metabolic process organonitrogen compound metabolic process cellular metabolic process cellular process carnitine metabolic process, CoA-linked amino-acid betaine metabolic process cellular modified amino acid metabolic process catabolic process oxoacid metabolic process organic acid catabolic process organic acid metabolic process cellular lipid catabolic process cellular catabolic process monocarboxylic acid catabolic process fatty acid oxidation carboxylic acid catabolic process fatty acid beta-oxidation lipid oxidation fatty acid metabolic process lipid catabolic process carboxylic acid metabolic process lipid modification fatty acid catabolic process cellular lipid metabolic process monocarboxylic acid metabolic process small molecule catabolic process organic substance catabolic process lipid metabolic process heart development cellular developmental process cardiac muscle tissue development cardiac muscle cell differentiation muscle cell differentiation tissue development cardiocyte differentiation striated muscle tissue development circulatory system development muscle structure development cell differentiation striated muscle cell differentiation muscle tissue development amino-acid betaine biosynthetic process organonitrogen compound biosynthetic process carnitine biosynthetic process cellular modified amino acid biosynthetic process medium-chain fatty acid metabolic process medium-chain fatty acid catabolic process fatty acid beta-oxidation using acyl-CoA dehydrogenase post-embryonic development glucan biosynthetic process polysaccharide biosynthetic process energy derivation by oxidation of organic compounds cellular biosynthetic process glycogen metabolic process generation of precursor metabolites and energy glycogen biosynthetic process macromolecule biosynthetic process polysaccharide metabolic process glucan metabolic process energy reserve metabolic process macromolecule metabolic process response to nutrient levels response to starvation	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane membrane organelle envelope mitochondrial envelope organelle membrane axon membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane membrane organelle envelope mitochondrial envelope organelle membrane axon cell projection neuron projection plasma membrane bounded cell projection membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR006091	Acyl-CoA oxidase/dehydrogenase, middle domain	Domain
A, B, C, D	IPR036250	Acyl-CoA dehydrogenase-like, C-terminal	Homologous Superfamily
A, B, C, D	IPR037069	Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR009100	Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily	Homologous Superfamily
A, B, C, D	IPR034180	Medium-chain specific acyl-CoA dehydrogenase	Family
A, B, C, D	IPR009075	Acyl-CoA dehydrogenase/oxidase, C-terminal	Domain
A, B, C, D	IPR006089	Acyl-CoA dehydrogenase, conserved site	Conserved Site
A, B, C, D	IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal	Domain
A, B, C, D	IPR046373	Acyl-CoA oxidase/dehydrogenase, middle domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.