1UAS

Crystal structure of rice alpha-galactosidase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1uasa1	All beta proteins	Glycosyl hydrolase domain	Glycosyl hydrolase domain	alpha-Amylases, C-terminal beta-sheet domain	Melibiase	rice (Oryza sativa ) [TaxId: 4530 ],	SCOPe (2.08)
A	d1uasa2	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	Amylase, catalytic domain	Melibiase	rice (Oryza sativa ) [TaxId: 4530 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	alpha-Amylases C-terminal beta-sheet domain	8022500	4002636	SCOP2 (2022-06-29)
A	SCOP2 Family	Amylase catalytic domain	8022501	4003138	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Glycosyl hydrolase domain-like	8034880	3001528	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	(Trans)glycosidases	8034881	3000313	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Melibiase_2_C_2	e1uasA1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: Melibiase_2_C_2	ECOD (1.6)
A	Glyco_hydro_31_N	e1uasA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_31_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
A	2.60.40.1180	Mainly Beta	Sandwich	Immunoglobulin-like	Golgi alpha-mannosidase II	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16499	Alpha galactosidase A (Melibiase_2)	Alpha galactosidase A	-	Family
A	PF17801	Alpha galactosidase C-terminal beta sandwich domain (Melibiase_C)	Alpha galactosidase C-terminal beta sandwich domain	This domain is found at the C-terminus of alpha galactosidase enzymes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	alpha-galactosidase	alpha-galactosidase activity hydrolase activity, acting on glycosyl bonds raffinose alpha-galactosidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity galactosidase activity	carbohydrate metabolic process catabolic process substituted mannan metabolic process galactomannan metabolic process carbohydrate catabolic process primary metabolic process macromolecule catabolic process galactomannan catabolic process polysaccharide metabolic process organic substance metabolic process polysaccharide catabolic process metabolic process macromolecule metabolic process organic substance catabolic process	cell periphery external encapsulating structure plant-type cell wall cell wall cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000111	Glycoside hydrolase family 27/36, conserved site	Conserved Site
A	IPR002241	Glycoside hydrolase, family 27	Family
A	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A	IPR041233	Alpha galactosidase, C-terminal beta sandwich domain	Domain
A	IPR013780	Glycosyl hydrolase, all-beta	Homologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	alpha-galactosidase M-CSA #913	alpha-galactosidase is a member of the glycoside hydrolase, family 27 and catalyses the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids such as raffinose, melibiose, and stachyose (in descending order of reactivity).	Defined by 2 residues: ASP:A-130ASP:A-185 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 3.2.1.22 (PDB Primary Data) Search M-CSA Motif + EC 3.2.1.22

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.