1U78

Structure of the bipartite DNA-binding domain of Tc3 transposase bound to transposon DNA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1u78a1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Recombinase DNA-binding domain	Transposase tc3a1-65	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	Recombinase DNA-binding domain-like	8003600	4000311	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Family	Recombinase DNA-binding domain-like	8003601	4000311	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	Homeodomain-like	8044640	3000001	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	Homeodomain-like	8044641	3000001	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	HTH_Tnp_Tc3_1	e1u78A1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: HTH_Tnp_Tc3_1	ECOD (1.6)
C [auth A]	HTH_Tnp_Tc3_2_like	e1u78A2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: HTH_Tnp_Tc3_2_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)
C [auth A]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A]	PF21517	Transposable element Tc3 transposase, HTH (HTH_Tnp_Tc3_2_like)	Transposable element Tc3 transposase, HTH	Tc3 is transposase with a specific DNA-binding domain. It binds specifically to the terminal nucleotides of the TC3 inverted repeat and acts by making double strand breaks at the ends of TC3 element. It has two DNA-binding domains at the N-terminal, ...	Tc3 is transposase with a specific DNA-binding domain. It binds specifically to the terminal nucleotides of the TC3 inverted repeat and acts by making double strand breaks at the ends of TC3 element. It has two DNA-binding domains at the N-terminal, the first one represented in Pfam:PF11427 and the second one in this entry [1]. They both bind to the major groove on a single DNA oligomer, separated by a linker that interacts closely with the minor groove [1].	Domain
C [auth A]	PF11427	Tc3 transposase (HTH_Tnp_Tc3_1)	Tc3 transposase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	26-MER	-	-	-
B [auth C]	26-MER	-	-	-
C [auth A]	transposable element tc3 transposase	DNA binding binding organic cyclic compound binding nucleic acid binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process DNA integration nucleic acid metabolic process DNA recombination	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A]	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
C [auth A]	IPR025898	Tc3 transposase, DNA binding domain	Domain
C [auth A]	IPR048703	Transposable element Tc3 transposase-like, DNA-binding HTH domain	Domain
C [auth A]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
C [auth A]	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
C [auth A]	IPR038717	Tc1-like transposase, DDE domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.