1U38

Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1u38a1	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	Amyloid beta A4 precursor protein-binding family A member 1 (APBA1, X11)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1u38a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e1u38A1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	amyloid beta A4 precursor protein-binding, family A, member 1	amide binding amyloid-beta binding binding peptide binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis behavior multicellular organismal process locomotory behavior trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis behavior multicellular organismal process locomotory behavior trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling biological regulation cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication organic anion transport nitrogen compound transport carboxylic acid transport transport secretion organic substance transport export from cell establishment of localization organic acid transport amino acid transport localization acidic amino acid transport secretion by cell dicarboxylic acid transport glutamate secretion cellular localization intracellular transport axo-dendritic transport establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process regulation of biosynthetic process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process gamma-aminobutyric acid secretion acid secretion gamma-aminobutyric acid transport developmental process multicellular organism development embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development protein localization establishment of protein localization protein transport cellular macromolecule localization macromolecule localization intracellular protein transport nervous system development system development cell adhesion multicellular organism growth developmental growth growth	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane synapse cell junction glutamatergic synapse presynaptic active zone membrane presynaptic membrane synaptic membrane presynapse intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane synapse cell junction glutamatergic synapse presynaptic active zone membrane presynaptic membrane synaptic membrane presynapse plasma membrane region presynaptic active zone membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree Schaffer collateral - CA1 synapse perinuclear region of cytoplasm transport vesicle intracellular vesicle cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle nucleus
B	PVYI	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR006020	PTB/PI domain	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q02410	lung carcinoma ovarian cancer malignant colon neoplasm psoriasis medulloblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.