1U0S

Chemotaxis kinase CheA P2 domain in complex with response regulator CheY from the thermophile thermotoga maritima

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth Y]	d1u0sy_	Alpha and beta proteins (a/b)	Flavodoxin-like	CheY-like	CheY-related	CheY protein	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
B [auth A]	d1u0sa_	Alpha and beta proteins (a+b)	Ferredoxin-like	CheY-binding domain of CheA	CheY-binding domain of CheA	CheY-binding domain of CheA	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth Y]	SCOP2 Family	CheY-related	8028257	4003632	SCOP2 (2022-06-29)
A [auth Y]	SCOP2 Superfamily	CheY-like	8040636	3001156	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Family	CheY-binding domain of CheA	8028254	4001293	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	CheY-binding domain of CheA	8040633	3001231	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth Y]	PF00072	e1u0sY1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: PF00072	ECOD (1.6)
B [auth A]	PF07194	e1u0sA1	A: a+b two layers	X: Alpha-beta plaits	H: CheY-binding domain of CheA (From Topology)	T: CheY-binding domain of CheA	F: PF07194	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth Y]	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)
B [auth A]	3.30.70.1110	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Histidine kinase CheA-like, P2 response regulator-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth Y]	PF00072	Response regulator receiver domain (Response_reg)	Response regulator receiver domain	This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	Domain
B [auth A]	PF07194	P2 response regulator binding domain (P2)	P2 response regulator binding domain	The response regulators for CheA bind to the P2 domain, which is found between Pfam:PF01627 and Pfam:PF02895 as either one or two copies. Highly flexible linkers connect P2 to the rest of CheA and impart remarkable mobility to the P2 domain. This f ...	The response regulators for CheA bind to the P2 domain, which is found between Pfam:PF01627 and Pfam:PF02895 as either one or two copies. Highly flexible linkers connect P2 to the rest of CheA and impart remarkable mobility to the P2 domain. This feature is thought to enhance the inter CheA dimer phosphotransfer reactions within the signalling complex, thereby amplifying the phosphorylation signal [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth Y]	Chemotaxis protein cheY	cation binding ion binding binding metal ion binding small molecule binding	chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion cellular process cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility cellular response to stimulus regulation of biological process phosphorelay signal transduction system regulation of cellular process chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion cellular process cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility cellular response to stimulus regulation of biological process phosphorelay signal transduction system regulation of cellular process signaling biological regulation intracellular signal transduction cell communication signal transduction	intracellular anatomical structure cytoplasm cellular anatomical entity
B [auth A]	Chemotaxis protein cheA	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding protein domain specific binding catalytic activity, acting on a protein small molecule sensor activity kinase activity protein kinase activity transferase activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups phosphorelay sensor kinase activity catalytic activity	chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth Y]	IPR011006	CheY-like superfamily	Homologous Superfamily
A [auth Y]	IPR001789	Signal transduction response regulator, receiver domain	Domain
B [auth A]	IPR037006	Histidine kinase CheA-like, homodimeric domain superfamily	Homologous Superfamily
B [auth A]	IPR004358	Signal transduction histidine kinase-related protein, C-terminal	Domain
B [auth A]	IPR004105	Histidine kinase CheA-like, homodimeric domain	Domain
B [auth A]	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
B [auth A]	IPR036097	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily	Homologous Superfamily
B [auth A]	IPR036061	CheW-like domain superfamily	Homologous Superfamily
B [auth A]	IPR037052	Chemotaxis protein CheA, P2 response regulator-binding domain superfamily	Homologous Superfamily
B [auth A]	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
B [auth A]	IPR010808	Chemotaxis protein CheA, P2 response regulator-binding	Domain
B [auth A]	IPR002545	CheW-like domain	Domain
B [auth A]	IPR005467	Histidine kinase domain	Domain
B [auth A]	IPR036641	HPT domain superfamily	Homologous Superfamily
B [auth A]	IPR008207	Signal transduction histidine kinase, phosphotransfer (Hpt) domain	Domain
B [auth A]	IPR035891	CheY-binding domain of CheA	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.