1TMR

THE STRUCTURE OF A 19 RESIDUE FRAGMENT FROM THE C-LOOP OF THE FOURTH EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF THROMBOMODULIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1tmra_	Small proteins	Knottins (small inhibitors, toxins, lectins)	EGF/Laminin	EGF-type module	Thrombomodulin, different EGF-like domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	THROMBOMODULIN PRECURSOR	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding molecular transducer activity signaling receptor activity transmembrane signaling receptor activity	multicellular organismal process regulation of body fluid levels regulation of cellular process response to stimulus regulation of response to external stimulus negative regulation of biological process regulation of cell activation negative regulation of platelet activation regulation of response to wounding regulation of coagulation response to stress regulation of response to stress negative regulation of cellular process coagulation multicellular organismal process regulation of body fluid levels regulation of cellular process response to stimulus regulation of response to external stimulus negative regulation of biological process regulation of cell activation negative regulation of platelet activation regulation of response to wounding regulation of coagulation response to stress regulation of response to stress negative regulation of cellular process coagulation regulation of multicellular organismal process regulation of biological quality response to wounding regulation of hemostasis wound healing regulation of biological process negative regulation of response to stimulus negative regulation of wound healing regulation of blood coagulation negative regulation of blood coagulation biological regulation hemostasis cell activation response to external stimulus negative regulation of response to wounding blood coagulation negative regulation of cell activation negative regulation of hemostasis regulation of platelet activation negative regulation of coagulation regulation of response to stimulus negative regulation of response to external stimulus regulation of wound healing cellular process negative regulation of multicellular organismal process platelet activation multi-multicellular organism process reproductive process female pregnancy multi-organism reproductive process blood coagulation, common pathway cellular biosynthetic process protein maturation organic substance metabolic process blood coagulation, fibrin clot formation organic substance biosynthetic process protein metabolic process protein activation cascade organonitrogen compound metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process biosynthetic process metabolic process macromolecule metabolic process response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus positive regulation of coagulation positive regulation of biological process positive regulation of blood coagulation positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of hemostasis positive regulation of response to wounding positive regulation of wound healing fibrinolysis regulation of fibrinolysis positive regulation of multicellular organismal process negative regulation of fibrinolysis response to organic substance response to chemical response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP response to organic cyclic compound proteolysis zymogen activation protein processing biological process involved in interspecies interaction between organisms response to lipid response to other organism response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane apicolateral plasma membrane plasma membrane region protein-containing complex catalytic complex peptidase complex endopeptidase complex serine-type endopeptidase complex cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane apicolateral plasma membrane plasma membrane region protein-containing complex catalytic complex peptidase complex endopeptidase complex serine-type endopeptidase complex serine-type peptidase complex vacuolar membrane membrane-bounded organelle intracellular anatomical structure vacuole intracellular membrane-bounded organelle intracellular organelle bounding membrane of organelle organelle cytoplasm organelle membrane extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016187	C-type lectin fold	Homologous Superfamily
A	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A	IPR026823	Complement Clr-like EGF domain	Domain
A	IPR001304	C-type lectin-like	Domain
A	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A	IPR000742	EGF-like domain	Domain
A	IPR015149	Thrombomodulin-like, EGF-like	Domain
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR001881	EGF-like calcium-binding domain	Domain
A	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P07204	thrombophilia atypical hemolytic-uremic syndrome thrombomodulin-related bleeding disorder thrombotic thrombocytopenic purpura acute promyelocytic leukemia adult acute respiratory distress syndrome pulmonary embolism myocardial infarction hemolytic-uremic syndrome neuropathy, painful disseminated intravascular coagulation Liver Cirrhosis, Experimental atypical hemolytic-uremic syndrome with thrombomodulin anomaly thrombotic disease gastric cancer thrombophilia atypical hemolytic-uremic syndrome thrombomodulin-related bleeding disorder thrombotic thrombocytopenic purpura acute promyelocytic leukemia adult acute respiratory distress syndrome pulmonary embolism myocardial infarction hemolytic-uremic syndrome neuropathy, painful disseminated intravascular coagulation Liver Cirrhosis, Experimental atypical hemolytic-uremic syndrome with thrombomodulin anomaly thrombotic disease gastric cancer vascular disease interstitial cystitis lung cancer pancreatic intraductal papillary-mucinous carcinoma psoriasis breast carcinoma hemolytic anemia hereditary diffuse gastric adenocarcinoma lung carcinoma medulloblastoma adenoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia congenital thrombotic thrombocytopenic purpura ulcerative colitis lung adenocarcinoma adrenal cortex carcinoma ovarian cancer pituitary cancer breast cancer cystic fibrosis gastric neoplasm

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.