1TH1

Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1th1a_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	beta-Catenin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1th1b_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	beta-Catenin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8040103	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8040103	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Arm_1	e1th1A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Arm_1	ECOD (1.6)
B	Arm_1	e1th1B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Arm_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00514	Armadillo/beta-catenin-like repeat (Arm)	Armadillo/beta-catenin-like repeat	-	Repeat
C, D	PF05923	APC repeat (APC_r)	APC repeat	-	Motif

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Beta-catenin	protein binding binding alpha-catenin binding protein phosphatase binding phosphatase binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding signaling receptor binding kinase binding protein kinase binding SMAD binding transcription factor binding DNA-binding transcription factor binding protein binding binding alpha-catenin binding protein phosphatase binding phosphatase binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding signaling receptor binding kinase binding protein kinase binding SMAD binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cell adhesion molecule binding cadherin binding histone methyltransferase binding transcription coregulator binding transcription corepressor binding nuclear estrogen receptor binding I-SMAD binding protein-containing complex binding chromatin binding transmembrane transporter binding disordered domain specific binding protein domain specific binding	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis regulation of angiogenesis anatomical structure development anatomical structure formation involved in morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development oviduct development reproductive system development reproductive process developmental process involved in reproduction reproductive structure development dorsal/ventral pattern formation dorsal/ventral axis specification pattern specification process axis specification regionalization regulation of cellular process cellular developmental process cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development neurogenesis cell differentiation cellular process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway cell population proliferation regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation smooth muscle cell proliferation embryonic skeletal joint development limb development chordate embryonic development embryonic limb morphogenesis embryonic appendage morphogenesis embryo development embryonic skeletal joint morphogenesis embryo development ending in birth or egg hatching skeletal system development animal organ morphogenesis embryonic organ development embryonic skeletal system morphogenesis embryonic organ morphogenesis embryonic skeletal limb joint morphogenesis appendage development embryonic morphogenesis animal organ development appendage morphogenesis limb joint morphogenesis embryonic skeletal system development skeletal system morphogenesis limb morphogenesis heart morphogenesis cardioblast proliferation regulation of cardioblast proliferation animal organ formation regulation of secondary heart field cardioblast proliferation heart development heart formation cell proliferation involved in heart morphogenesis regulation of cell proliferation involved in heart morphogenesis response to fibroblast growth factor positive regulation of cell communication cellular response to growth factor stimulus positive regulation of signal transduction positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of signaling response to endogenous stimulus regulation of cellular response to growth factor stimulus regulation of response to stimulus fibroblast growth factor receptor signaling pathway regulation of cell communication response to growth factor cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway positive regulation of signaling regulation of timing of anagen epidermis development molting cycle process anagen hair cycle phase skin epidermis development hair follicle development hair follicle maturation regulation of hair follicle maturation epithelium development biological phase hair cycle developmental maturation tissue development skin development anatomical structure maturation molting cycle hair cycle process maintenance of cell number stem cell population maintenance prostate gland development gland development epithelial cell proliferation involved in prostate gland development urogenital system development epithelial cell proliferation trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission detection of external stimulus detection of stimulus detection of mechanical stimulus detection of muscle stretch response to mechanical stimulus response to external stimulus response to abiotic stimulus detection of abiotic stimulus response to muscle stretch adherens junction organization adherens junction assembly cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cellular component organization or biogenesis cell-cell junction organization cell-cell junction assembly negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of gliogenesis negative regulation of neurogenesis gliogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process regulation of glial cell differentiation negative regulation of gliogenesis negative regulation of cell development negative regulation of oligodendrocyte differentiation negative regulation of glial cell differentiation central nervous system development oligodendrocyte differentiation glial cell differentiation negative regulation of multicellular organismal process regulation of oligodendrocyte differentiation positive regulation of glycoprotein metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of sulfur metabolic process sulfur compound metabolic process positive regulation of macromolecule metabolic process positive regulation of heparan sulfate proteoglycan biosynthetic process regulation of protein metabolic process regulation of heparan sulfate proteoglycan biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process sulfur compound biosynthetic process proteoglycan metabolic process positive regulation of proteoglycan biosynthetic process proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process positive regulation of sulfur metabolic process positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of biosynthetic process protein metabolic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process positive regulation of cellular biosynthetic process epidermal cell differentiation epithelial cell differentiation hair cell differentiation generation of neurons neuron differentiation negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death protein localization localization cellular localization protein localization to cell surface cellular macromolecule localization macromolecule localization sexual reproduction multicellular organismal reproductive process oogenesis cellular process involved in reproduction in multicellular organism female gamete generation gamete generation oocyte development germ cell development oocyte differentiation developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell growth cell morphogenesis cell projection morphogenesis neuron projection morphogenesis neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth developmental growth involved in morphogenesis neuron development branching morphogenesis of an epithelial tube respiratory tube development lung morphogenesis lung development respiratory system development epithelial tube morphogenesis morphogenesis of an epithelium tissue morphogenesis morphogenesis of a branching structure epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium sympathetic nervous system development ganglion development autonomic nervous system development sympathetic ganglion development positive regulation of mesenchymal cell proliferation positive regulation of cell population proliferation regulation of mesenchymal cell proliferation mesenchymal cell proliferation synapse organization vesicle localization transport synaptic vesicle clustering synaptic vesicle cycle establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse organelle localization establishment of localization in cell synaptic vesicle localization cell maturation anterior/posterior axis specification anterior/posterior pattern specification positive regulation of odontoblast differentiation regulation of epithelial cell differentiation positive regulation of developmental process positive regulation of cell differentiation neuroepithelial cell differentiation odontoblast differentiation regulation of odontoblast differentiation positive regulation of epithelial cell differentiation columnar/cuboidal epithelial cell differentiation positive regulation of neuroepithelial cell differentiation apoptotic signaling pathway myeloid leukocyte differentiation hemopoiesis myeloid cell differentiation osteoclast differentiation leukocyte differentiation camera-type eye morphogenesis sensory organ development eye development visual system development eye morphogenesis lens morphogenesis in camera-type eye sensory organ morphogenesis camera-type eye development sensory system development lens development in camera-type eye negative regulation of blood vessel morphogenesis negative regulation of angiogenesis negative regulation of vasculature development negative regulation of post-translational protein modification regulation of protein sumoylation regulation of protein modification process peptidyl-lysine modification peptidyl-amino acid modification negative regulation of protein modification process protein modification process regulation of protein modification by small protein conjugation or removal negative regulation of protein sumoylation negative regulation of protein metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification protein sumoylation macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal outflow tract morphogenesis cell fate specification cell fate commitment forebrain development glial cell migration telencephalon glial cell migration cerebral cortex development telencephalon cell migration forebrain cell migration cell migration cell motility layer formation in cerebral cortex cerebral cortex cell migration head development brain development cerebral cortex radially oriented cell migration pallium development cerebral cortex radial glia-guided migration telencephalon development hindbrain development positive regulation of gene expression regulation of stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation in utero embryonic development intracellular signal transduction intracellular signaling cassette MAPK cascade cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation immune system process T cell differentiation neuron fate commitment cell fate determination neuron fate determination positive regulation of determination of dorsal identity regulation of determination of dorsal identity determination of bilateral symmetry determination of dorsal/ventral asymmetry positive regulation of multicellular organismal process determination of dorsal identity specification of symmetry intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of neuron apoptotic process negative regulation of signaling negative regulation of intracellular signal transduction regulation of intrinsic apoptotic signaling pathway negative regulation of cell communication regulation of intracellular signal transduction negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of response to stimulus negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of signal transduction neuron intrinsic apoptotic signaling pathway in response to oxidative stress negative regulation of intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of neuron apoptotic process regulation of apoptotic signaling pathway canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation stem cell differentiation mesenchymal stem cell differentiation mesonephric epithelium development kidney epithelium development nephron morphogenesis nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis branching involved in ureteric bud morphogenesis renal tubule development nephron development nephron epithelium development ureteric bud development mesonephros development kidney morphogenesis mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis microtubule organizing center organization regulation of cell cycle process microtubule cytoskeleton organization centriole-centriole cohesion organelle organization centrosome cycle microtubule-based process cell cycle regulation of cell cycle regulation of centriole-centriole cohesion cytoskeleton organization cell cycle process multicellular organismal-level homeostasis homeostatic process tissue remodeling bone remodeling anatomical structure homeostasis tissue homeostasis bone resorption ossification osteoblast differentiation immune system development hematopoietic or lymphoid organ development thymus development transcription by RNA polymerase II cranial ganglion development nerve development cranial nerve development foregut regionalization developmental induction regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis specification of animal organ identity regulation of branching involved in lung morphogenesis regulation of morphogenesis of an epithelium morphogenesis of an epithelial bud morphogenesis of an epithelial fold morphogenesis of embryonic epithelium regulation of embryonic development lung field specification lung induction primary lung bud formation positive regulation of animal organ morphogenesis regulation of animal organ formation organ induction glial cell fate determination glial cell fate commitment pancreas development positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade embryonic axis specification embryonic pattern specification positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process dopaminergic neuron differentiation midbrain development midbrain dopaminergic neuron differentiation neuron migration regulation of transcription by RNA polymerase II regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II positive regulation of transcription by RNA polymerase II transcription elongation by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II positive regulation of DNA-templated transcription, elongation DNA-templated transcription elongation response to chemical response to xenobiotic stimulus epithelial cell differentiation involved in prostate gland development digestive system development foregut morphogenesis digestive tract development embryonic foregut morphogenesis digestive tract morphogenesis myoblast proliferation astrocyte-dopaminergic neuron signaling glial cell-neuron signaling regulation of epithelial cell differentiation involved in kidney development regulation of nephron tubule epithelial cell differentiation epithelial cell differentiation involved in kidney development nephron tubule epithelial cell differentiation cell differentiation involved in kidney development establishment of organelle localization establishment of vesicle localization synaptic vesicle transport dorsal root ganglion development genitalia development sex differentiation male sex differentiation male genitalia development endothelium development morphogenesis of an endothelium endothelial tube morphogenesis epidermis morphogenesis hair follicle morphogenesis embryonic hindlimb morphogenesis hindlimb morphogenesis mesenchymal cell proliferation involved in lung development branching involved in blood vessel morphogenesis positive regulation of myoblast proliferation regulation of myoblast proliferation metanephros development metanephros morphogenesis positive regulation of organelle organization telomere organization regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening positive regulation of telomere maintenance via telomere lengthening positive regulation of telomere maintenance DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization telomere maintenance positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase DNA biosynthetic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization telomere maintenance via telomerase chromosome organization positive regulation of DNA biosynthetic process regulation of telomere maintenance via telomerase positive regulation of endothelial cell differentiation endothelial cell differentiation regulation of endothelial cell differentiation regulation of synapse structure or activity regulation of synapse assembly regulation of biological quality regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization synapse assembly connective tissue development chondrocyte differentiation cartilage development negative regulation of transcription by RNA polymerase II formation of primary germ layer gastrulation cell fate commitment involved in formation of primary germ layer endoderm development endoderm formation endodermal cell fate commitment endodermal cell differentiation gastrulation with mouth forming second regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development epithelial to mesenchymal transition mesenchymal cell differentiation regulation of localization regulation of protein localization regulation of cellular localization regulation of protein localization to cell surface renal vesicle morphogenesis regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis negative regulation of epithelial cell differentiation involved in kidney development metanephric renal vesicle morphogenesis renal vesicle development negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric nephron development mesenchymal to epithelial transition involved in metanephros morphogenesis negative regulation of epithelial cell differentiation mesenchymal to epithelial transition metanephric nephron morphogenesis cell differentiation involved in metanephros development hypothalamus development diencephalon development limbic system development regulation of reproductive process regulation of epithelial cell proliferation involved in prostate gland development positive regulation of reproductive process positive regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation involved in prostate gland development regulation of epithelial cell proliferation regulation of mitotic cell cycle, embryonic negative regulation of cell cycle mitotic cell cycle negative regulation of mitotic cell cycle mitotic cell cycle, embryonic regulation of mitotic cell cycle negative regulation of mitotic cell cycle, embryonic organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process fibroblast proliferation regulation of fibroblast proliferation establishment of blood-retinal barrier acinar cell differentiation glandular epithelial cell differentiation muscle structure development smooth muscle cell differentiation muscle cell differentiation regulation of protein ubiquitination protein ubiquitination regulation of cartilage development regulation of chondrocyte differentiation negative regulation of cartilage development negative regulation of chondrocyte differentiation negative regulation of gene expression proximal/distal pattern formation response to organic substance response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound embryonic digit morphogenesis ectoderm development regulation of muscle tissue development skeletal muscle tissue development positive regulation of skeletal muscle tissue development regulation of skeletal muscle tissue development skeletal muscle organ development positive regulation of muscle tissue development muscle tissue development muscle organ development neuroblast proliferation neural precursor cell proliferation embryonic forelimb morphogenesis forelimb morphogenesis regulation of calcium ion import regulation of calcium ion transport regulation of transport regulation of monoatomic ion transport calcium ion transport metal ion transport monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport regulation of leukocyte activation regulation of cell activation leukocyte proliferation lymphocyte proliferation regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of T cell activation regulation of T cell proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process regulation of leukocyte differentiation regulation of osteoclast differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of immune system process regulation of hemopoiesis embryonic brain development protein polyubiquitination central nervous system vasculogenesis vasculogenesis genitalia morphogenesis sister chromatid cohesion centromeric sister chromatid cohesion regulation of centromeric sister chromatid cohesion regulation of sister chromatid cohesion cell adhesion lung epithelium development lung epithelial cell differentiation lung cell differentiation positive regulation of morphogenesis of an epithelium positive regulation of branching involved in lung morphogenesis neural plate development cell-matrix adhesion cell-substrate adhesion ectodermal placode morphogenesis hair follicle placode formation ectodermal placode formation ectodermal placode development regulation of myelination myelination axon ensheathment ensheathment of neurons establishment of blood-brain barrier lung-associated mesenchyme development odontogenesis of dentin-containing tooth odontogenesis cranial skeletal system development embryonic epithelial tube formation tube formation epithelial tube formation nephron tubule formation renal vesicle formation embryonic heart tube development trachea morphogenesis trachea formation trachea development negative regulation of cell population proliferation regulation of osteoblast differentiation positive regulation of osteoblast differentiation renal inner medulla development cellular response to nitrogen compound response to alcohol response to organonitrogen compound cellular response to organic cyclic compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol cellular response to organonitrogen compound response to indole-3-methanol cellular response to indole-3-methanol cellular response to organic substance cell-cell adhesion renal outer medulla development positive regulation of nervous system development regulation of neuroblast proliferation positive regulation of neurogenesis regulation of neural precursor cell proliferation positive regulation of cell development positive regulation of neural precursor cell proliferation positive regulation of neuroblast proliferation tongue development fungiform papilla formation fungiform papilla development fungiform papilla morphogenesis tongue morphogenesis	membrane raft protein-containing complex plasma membrane protein complex plasma membrane raft membrane plasma membrane membrane protein complex caveola cellular anatomical entity membrane microdomain cell periphery flotillin complex plasma membrane region cell-cell junction membrane raft protein-containing complex plasma membrane protein complex plasma membrane raft membrane plasma membrane membrane protein complex caveola cellular anatomical entity membrane microdomain cell periphery flotillin complex plasma membrane region cell-cell junction intercalated disc anchoring junction cell junction fascia adherens cell-cell contact zone focal adhesion cell-substrate junction membrane-bounded organelle RNA polymerase II transcription regulator complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle beta-catenin-TCF7L2 complex intracellular organelle catenin-TCF7L2 complex organelle beta-catenin-TCF complex catalytic complex beta-catenin destruction complex intracellular protein-containing complex Schaffer collateral - CA1 synapse synapse protein-DNA complex euchromatin chromatin chromosome intracellular non-membrane-bounded organelle non-membrane-bounded organelle cell projection cell leading edge plasma membrane bounded cell projection lamellipodium postsynapse postsynaptic membrane synaptic membrane cytoskeleton spindle spindle pole microtubule cytoskeleton Z disc sarcomere I band contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex apical part of cell extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle actin-based cell projection microvillus microvillus membrane cell projection membrane presynapse presynaptic membrane cell cortex cytoplasmic region presynaptic active zone cytoplasmic component cell cortex region presynaptic active zone extrinsic component of plasma membrane catenin complex extrinsic component of membrane Scrib-APC-beta-catenin complex glutamatergic synapse RNA polymerase II transcription repressor complex beta-catenin-ICAT complex transcription repressor complex adherens junction centrosome microtubule organizing center membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytosol lateral plasma membrane basal part of cell basal plasma membrane basolateral plasma membrane perinuclear region of cytoplasm postsynaptic density, intracellular component postsynaptic specialization postsynaptic specialization, intracellular component postsynaptic density neuron to neuron synapse asymmetric synapse apicolateral plasma membrane Wnt signalosome apical junction complex bicellular tight junction tight junction
C, D	Adenomatous polyposis coli protein	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding enzyme regulator activity molecular function regulator activity protein kinase regulator activity kinase regulator activity microtubule plus-end binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding gamma-catenin binding cytoskeletal protein binding microtubule binding protein binding binding tubulin binding enzyme regulator activity molecular function regulator activity protein kinase regulator activity kinase regulator activity microtubule plus-end binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding gamma-catenin binding kinase binding protein kinase binding beta-catenin binding protein-containing complex binding dynein complex binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process cellular developmental process cell differentiation cell fate specification cell fate commitment multicellular organism development multicellular organismal process anatomical structure development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process cellular developmental process cell differentiation cell fate specification cell fate commitment multicellular organism development multicellular organismal process anatomical structure development pattern specification process regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization cell projection organization positive regulation of biological process plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization pseudopodium assembly cellular component assembly positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process regulation of biological process plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly biological regulation regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly positive regulation of pseudopodium assembly regulation of pseudopodium assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly pseudopodium organization signaling negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death regulation of microtubule-based process regulation of microtubule-based movement microtubule-based movement microtubule-based process cell migration cell motility bicellular tight junction assembly tight junction organization apical junction assembly cell junction organization cell junction assembly tight junction assembly cell-cell junction assembly cell-cell junction organization nervous system development system development cell adhesion establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore regulation of cell cycle process establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation regulation of attachment of spindle microtubules to kinetochore cell cycle establishment of chromosome localization regulation of cell cycle chromosome segregation cell cycle process protein-containing complex organization protein-containing complex assembly mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cytokinesis cell division mitotic cell cycle regulation of cell cycle phase transition spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling mitotic sister chromatid separation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition regulation of mitotic cell cycle mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation mitotic nuclear division negative regulation of mitotic cell cycle phase transition organelle fission chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling organelle organization nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition catabolic process positive regulation of protein metabolic process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process regulation of catalytic activity negative regulation of catalytic activity regulation of cyclin-dependent protein kinase activity regulation of transferase activity negative regulation of cellular metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process regulation of cyclin-dependent protein serine/threonine kinase activity phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of protein serine/threonine kinase activity negative regulation of macromolecule metabolic process negative regulation of cyclin-dependent protein kinase activity negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process heart development mesenchyme morphogenesis endocardial cushion morphogenesis animal organ development heart morphogenesis mesenchyme development tissue development circulatory system development tissue morphogenesis anatomical structure morphogenesis endocardial cushion development animal organ morphogenesis heart valve development cellular response to nitrogen compound response to organic substance response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone cellular response to organic substance enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus response to endogenous stimulus response to organonitrogen compound response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical response to insulin cellular response to insulin stimulus negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition negative regulation of G1/S transition of mitotic cell cycle negative regulation of cell cycle G1/S phase transition regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion protein localization protein localization to microtubule cytoskeleton regulation of localization regulation of protein localization regulation of protein localization to centrosome protein localization to microtubule organizing center regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to cytoskeleton protein localization to organelle positive regulation of protein localization positive regulation of protein localization to centrosome protein localization to centrosome regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization negative regulation of microtubule depolymerization microtubule cytoskeleton organization protein-containing complex disassembly regulation of protein-containing complex disassembly microtubule polymerization or depolymerization regulation of microtubule depolymerization negative regulation of protein-containing complex disassembly negative regulation of supramolecular fiber organization cellular component disassembly negative regulation of microtubule polymerization or depolymerization regulation of protein depolymerization negative regulation of cytoskeleton organization negative regulation of protein depolymerization microtubule depolymerization regulation of supramolecular fiber organization supramolecular fiber organization protein depolymerization cytoskeleton organization regulation of microtubule cytoskeleton organization regulation of developmental process regulation of cell differentiation	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane plasma membrane membrane protein complex extrinsic component of membrane cell-cell junction adherens junction anchoring junction cell junction membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system perinuclear region of cytoplasm polymeric cytoskeletal fiber cytoskeleton intracellular non-membrane-bounded organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle ruffle leading edge membrane ruffle membrane plasma membrane region cell projection membrane centrosome microtubule organizing center catalytic complex beta-catenin destruction complex intracellular protein-containing complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Wnt signalosome chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome apical junction complex bicellular tight junction tight junction lateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR000225	Armadillo	Repeat
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR013284	Beta-catenin	Family
C, D	IPR016024	Armadillo-type fold	Homologous Superfamily
C, D	IPR009240	Adenomatous polyposis coli protein, 15 residue repeat	Repeat
C, D	IPR009232	EB-1 binding	Domain
C, D	IPR000225	Armadillo	Repeat
C, D	IPR009223	Adenomatous polyposis coli protein repeat	Repeat
C, D	IPR026818	Adenomatous polyposis coli (APC) family	Family
C, D	IPR036149	APC, N-terminal coiled-coil domain superfamily	Homologous Superfamily
C, D	IPR009224	SAMP	Repeat
C, D	IPR011989	Armadillo-like helical	Homologous Superfamily
C, D	IPR041257	Adenomatous polyposis coli (APC) repeat	Repeat
C, D	IPR026831	Adenomatous polyposis coli protein	Homologous Superfamily
C, D	IPR009234	Adenomatous polyposis coli protein basic domain	Domain
C, D	IPR032038	Adenomatous polyposis coli, N-terminal dimerisation domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P35222	medulloblastoma pilomatrixoma ovarian cancer kidney Wilms tumor severe intellectual disability-progressive spastic diplegia syndrome colorectal cancer hepatoblastoma craniopharyngioma adrenal cortex carcinoma hepatocellular adenoma angiosarcoma muscular atrophy adenoma Stevens-Johnson syndrome desmoid tumor medulloblastoma pilomatrixoma ovarian cancer kidney Wilms tumor severe intellectual disability-progressive spastic diplegia syndrome colorectal cancer hepatoblastoma craniopharyngioma adrenal cortex carcinoma hepatocellular adenoma angiosarcoma muscular atrophy adenoma Stevens-Johnson syndrome desmoid tumor breast cancer cirrhosis of liver malignant mesothelioma melanotic medulloblastoma breast carcinoma prostate cancer liver cancer cecal neoplasm Neoplasm Metastasis cervical cancer adenocarcinoma tubular adenocarcinoma malignant pancreatic neoplasm papillary adenoma adult medulloblastoma mantle cell lymphoma intellectual disability medullomyoblastoma with myogenic differentiation microcystic adenoma cecum cancer childhood medulloblastoma exudative vitreoretinopathy 7 follicular thyroid adenoma papillary craniopharyngioma intestinal cancer cancer adamantinous craniopharyngioma malignant colon neoplasm granular cell carcinoma adrenal gland cancer hepatocellular carcinoma desmoplastic/nodular medulloblastoma parathyroid gland adenoma hereditary Wilms tumor atypical teratoid rhabdoid tumor medulloblastoma with extensive nodularity intestinal disease brain disease drug-induced liver injury plasma cell myeloma kidney disease endometrial carcinoma psoriasis liver neoplasm exudative vitreoretinopathy 1 lung benign neoplasm colon carcinoma non-small cell lung carcinoma stomach disease lymphatic system disease gastric carcinoma malignant ependymoma ovarian neoplasm hematologic disease adrenal cortex adenoma uterine disease cribriform carcinoma pancreatic intraductal papillary-mucinous neoplasm cystadenoma peritoneal neoplasm benign colon neoplasm Perlman syndrome intestinal neoplasm breast disease endometriosis prostate disease esophageal squamous cell carcinoma lung disease colonic neoplasm osteoporosis toxic epidermal necrolysis colorectal carcinoma ovarian carcinoma glioblastoma urinary bladder disease pancreatic ductal adenocarcinoma cribriform carcinoma of breast pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia melanoma Emery-Dreifuss muscular dystrophy primitive neuroectodermal tumor large cell medulloblastoma endometrium carcinoma in situ liver disease schizophrenia lung adenocarcinoma colorectal adenocarcinoma osteosarcoma gastric adenocarcinoma tuberculosis ovarian disease adrenal carcinoma pancreatic intraductal papillary-mucinous carcinoma vertebral column disease cutaneous melanoma pancreatic neoplasm adult hepatocellular carcinoma
C, D	Pharos: P25054	medulloblastoma classic familial adenomatous polyposis glioblastoma colorectal cancer desmoid tumor hepatocellular carcinoma intellectual disability Adenomatous Polyps malignant colon neoplasm mismatch repair cancer syndrome 1 non-small cell lung carcinoma gastric cancer adenoma papillary adenoma follicular thyroid adenoma medulloblastoma classic familial adenomatous polyposis glioblastoma colorectal cancer desmoid tumor hepatocellular carcinoma intellectual disability Adenomatous Polyps malignant colon neoplasm mismatch repair cancer syndrome 1 non-small cell lung carcinoma gastric cancer adenoma papillary adenoma follicular thyroid adenoma Cenani-Lenz syndactyly syndrome giant cell glioblastoma rectal neoplasm granular cell carcinoma adult medulloblastoma microcystic adenoma liver cancer Gardner syndrome Lynch syndrome cancer prostate cancer colorectal adenoma tubular adenocarcinoma medullomyoblastoma with myogenic differentiation intestinal cancer familial adenomatous polyposis 1 benign colon neoplasm macrocytic anemia childhood medulloblastoma hepatoblastoma adenocarcinoma melanotic medulloblastoma inflammatory bowel disease adult acute respiratory distress syndrome benign mesothelioma liver neoplasm malignant glioma psoriasis colorectal adenocarcinoma colorectal carcinoma stomach carcinoma in situ medulloblastoma with extensive nodularity cribriform carcinoma of breast digestive system cancer attenuated familial adenomatous polyposis large cell medulloblastoma ovarian cancer benign neoplasm of pancreas Pick disease lung adenocarcinoma gastric carcinoma colon carcinoma rectal cancer schizophrenia mammary neoplasms, animal hereditary diffuse gastric adenocarcinoma hyperlipidemia adrenal cortex carcinoma desmoplastic/nodular medulloblastoma digestive system disease intestinal polyp atypical teratoid rhabdoid tumor pancreatic neoplasm benign neoplasm of stomach pilocytic astrocytoma lung benign neoplasm primitive neuroectodermal tumor gastric neoplasm malignant ependymoma genetic intestinal polyposis colonic neoplasm rectal carcinoma glioma cribriform carcinoma mesothelioma diabetes mellitus intestinal neoplasm astrocytic tumor exocrine pancreatic carcinoma autism oligodendroglioma familial hyperlipidemia

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C, D	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046
C, D	TPO	Parent Component: THR RESID: AA0037 , AA0038 PSI-MOD : O-phospho-L-serine MOD:00046 , O-phospho-L-threonine MOD:00047

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.