1TDQ

Structural basis for the interactions between tenascins and the C-type lectin domains from lecticans: evidence for a cross-linking role for tenascins

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1tdqa1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Tenascin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d1tdqa4	Artifacts	Tags	Tags	Tags	N-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1tdqb_	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	Aggrecan core protein	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Fibronectin type III	8055112	4007555	SCOP2 (2022-06-29)
A	SCOP2 Family	Fibronectin type III	8055500	4007555	SCOP2 (2022-06-29)
A	SCOP2 Family	Fibronectin type III	8055502	4007555	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Fibronectin type III	8055113	3002063	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Fibronectin type III	8055501	3002063	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Fibronectin type III	8055503	3002063	SCOP2 (2022-06-29)
B	SCOP2 Family	C-type lectin domain	8027755	4002453	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	C-type lectin-like	8040134	3001261	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00041	e1tdqA3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)
B	PF00059	e1tdqB1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain	-	Domain
B	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tenascin-R	cell adhesion molecule binding protein-containing complex binding protein binding binding integrin binding signaling receptor binding	regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process positive regulation of cell communication multicellular organismal process system process nervous system process regulation of system process positive regulation of biological process positive regulation of transmission of nerve impulse transmission of nerve impulse regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process positive regulation of cell communication multicellular organismal process system process nervous system process regulation of system process positive regulation of biological process positive regulation of transmission of nerve impulse transmission of nerve impulse regulation of nervous system process cell communication regulation of transmission of nerve impulse positive regulation of nervous system process positive regulation of multicellular organismal process regulation of cell communication regulation of multicellular organismal process positive regulation of cellular process signaling modulation of chemical synaptic transmission synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic synaptic signaling trans-synaptic signaling regulation of signaling positive regulation of synaptic transmission cell-cell signaling positive regulation of synaptic transmission, glutamatergic chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling positive regulation of signaling axon extension regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization negative regulation of biological process regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development multicellular organism development cell projection morphogenesis neuron differentiation negative regulation of growth neuron projection morphogenesis cell differentiation anatomical structure development regulation of biological quality system development developmental process negative regulation of cellular component organization regulation of cell projection organization negative regulation of cell growth nervous system development developmental growth involved in morphogenesis generation of neurons negative regulation of axonogenesis negative regulation of developmental growth negative regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension cellular component organization regulation of nervous system development neurogenesis negative regulation of neurogenesis regulation of extent of cell growth regulation of axonogenesis negative regulation of cellular process negative regulation of nervous system development negative regulation of cell differentiation cellular component organization or biogenesis negative regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth negative regulation of developmental process growth negative regulation of axon extension axon development regulation of cell growth cell morphogenesis involved in neuron differentiation negative regulation of neuron projection development anatomical structure morphogenesis negative regulation of cell development neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size cellular response to stimulus response to stimulus regulation of cellular response to stress sprouting of injured axon regulation of sprouting of injured axon response to external stimulus regulation of response to stimulus regulation of response to external stimulus response to axon injury regulation of response to wounding axon regeneration regulation of response to stress negative regulation of axon extension involved in regeneration negative regulation of sprouting of injured axon axon extension involved in regeneration negative regulation of neuron projection regeneration regeneration neuron projection regeneration regulation of axon extension involved in regeneration response to wounding regulation of axon regeneration negative regulation of response to external stimulus regulation of neuron projection regeneration negative regulation of axon regeneration cellular response to stress response to stress negative regulation of response to stimulus negative regulation of response to wounding head development forebrain development animal organ development brain development telencephalon cell migration central nervous system development forebrain cell migration cell migration telencephalon development cell motility extracellular matrix organization extracellular structure organization external encapsulating structure organization neuromuscular process neuromuscular process controlling balance cell junction organization synapse organization regulation of cell motility regulation of locomotion regulation of cell migration locomotion behavior locomotory behavior exploration behavior locomotory exploration behavior negative regulation of cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion regulation of cell-cell adhesion neuron cell-cell adhesion negative regulation of signaling negative regulation of synaptic transmission negative regulation of cell communication learning learning or memory cognition associative learning neuroblast migration long-term synaptic potentiation regulation of synaptic plasticity	cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity cell surface protein-containing complex protein complex involved in cell-matrix adhesion tenascin complex protein complex involved in cell adhesion membrane microdomain membrane raft membrane synapse cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity cell surface protein-containing complex protein complex involved in cell-matrix adhesion tenascin complex protein complex involved in cell adhesion membrane microdomain membrane raft membrane synapse cell junction glutamatergic synapse neuron to neuron synapse hippocampal mossy fiber to CA3 synapse perisynaptic extracellular matrix synapse-associated extracellular matrix perineuronal net Schaffer collateral - CA1 synapse extracellular matrix of synaptic cleft extracellular region extracellular space
B	Aggrecan core protein	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding carbohydrate binding glycosaminoglycan binding carbohydrate derivative binding hyaluronic acid binding	response to stimulus response to chemical response to xenobiotic stimulus developmental process multicellular organism development multicellular organismal process spinal cord development central nervous system development anatomical structure development nervous system development system development heart development animal organ development circulatory system development response to stimulus response to chemical response to xenobiotic stimulus developmental process multicellular organism development multicellular organismal process spinal cord development central nervous system development anatomical structure development nervous system development system development heart development animal organ development circulatory system development cellular developmental process connective tissue development cell development tissue development skeletal system development cell differentiation chondrocyte differentiation cellular process chondrocyte development cartilage development chondroblast differentiation response to hexose response to organic substance response to monosaccharide response to carbohydrate response to glucose response to oxygen-containing compound cell aggregation cartilage condensation anatomical structure morphogenesis skeletal system morphogenesis animal organ morphogenesis cellular component organization collagen fibril organization extracellular matrix organization cellular component organization or biogenesis supramolecular fiber organization extracellular structure organization external encapsulating structure organization carbohydrate derivative biosynthetic process proteoglycan biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process proteoglycan metabolic process response to mechanical stimulus response to abiotic stimulus response to external stimulus cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus response to growth factor negative regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process biological regulation negative regulation of biological process regulation of locomotion negative regulation of cellular process regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion ossification cell adhesion response to organic cyclic compound response to pH response to acidic pH response to gravity neuroblast proliferation positive regulation of nervous system development positive regulation of cell population proliferation regulation of developmental process positive regulation of biological process regulation of neuroblast proliferation regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process neurogenesis positive regulation of cell differentiation positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of cellular process regulation of neural precursor cell proliferation regulation of multicellular organismal development cell population proliferation positive regulation of cell development generation of neurons positive regulation of neural precursor cell proliferation regulation of cell population proliferation positive regulation of multicellular organismal process positive regulation of neuroblast proliferation neural precursor cell proliferation gliogenesis glial cell differentiation	basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity GABA-ergic synapse synapse cell junction glutamatergic synapse perisynaptic extracellular matrix synapse-associated extracellular matrix perineuronal net somatodendritic compartment basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity GABA-ergic synapse synapse cell junction glutamatergic synapse perisynaptic extracellular matrix synapse-associated extracellular matrix perineuronal net somatodendritic compartment cell body neuronal cell body extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013111	EGF-like domain, extracellular	Domain
A	IPR041161	Tenascin, EGF-like domain	Domain
A	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Homologous Superfamily
A	IPR000742	EGF-like domain	Domain
A	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Domain
A	IPR003961	Fibronectin type III	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR036056	Fibrinogen-like, C-terminal	Homologous Superfamily
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR003599	Immunoglobulin subtype	Domain
B	IPR016187	C-type lectin fold	Homologous Superfamily
B	IPR001304	C-type lectin-like	Domain
B	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
B	IPR013106	Immunoglobulin V-set domain	Domain
B	IPR000436	Sushi/SCR/CCP domain	Domain
B	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
B	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
B	IPR000538	Link domain	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR018378	C-type lectin, conserved site	Conserved Site
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR033987	Aggrecan/versican, C-type lectin-like domain	Domain