Annotations: 1T3B

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1t3ba1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	DsbC/DsbG C-terminal domain-like	Disulfide bond isomerase, DsbC, C-terminal domain	(Haemophilus influenzae ) [TaxId: 727 ],	SCOPe (2.08)
A	d1t3ba2	Alpha and beta proteins (a+b)	Cystatin-like	DsbC/DsbG N-terminal domain-like	DsbC/DsbG N-terminal domain-like	Disulfide bond isomerase, DsbC, N-terminal domain	(Haemophilus influenzae ) [TaxId: 727 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DsbC/DsbG C-terminal domain-like	8027539	4000486	SCOP2 (2022-06-29)
A	SCOP2 Family	DsbC/DsbG N-terminal domain-like	8027541	4001018	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioredoxin-like	8039918	3000031	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DsbC/DsbG N-terminal domain-like	8039920	3000466	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DsbC_N	e1t3bA1	A: a+b two layers	X: Cystatin-like	H: DsbC/DsbG N-terminal domain-like (From Topology)	T: DsbC/DsbG N-terminal domain-like	F: DsbC_N	ECOD (1.6)
A	DSBA_1	e1t3bA2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: DSBA_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.450.70	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF10411	Disulfide bond isomerase protein N-terminus (DsbC_N)	Disulfide bond isomerase protein N-terminus	This is the N-terminal domain of the disulfide bond isomerase DsbC. The whole molecule is V-shaped, where each arm is a DsbC monomer of two domains linked by a hinge; and the N-termini of each monomer join to form the dimer interface at the base of t ...	This is the N-terminal domain of the disulfide bond isomerase DsbC. The whole molecule is V-shaped, where each arm is a DsbC monomer of two domains linked by a hinge; and the N-termini of each monomer join to form the dimer interface at the base of the V, so are vital for dimerisation [1]. DsbC is required for disulfide bond formation and functions as a disulfide bond isomerase during oxidative protein-folding in bacterial periplasm. It also has chaperone activity [2].	Domain
A	PF13098	Thioredoxin-like domain (Thioredoxin_2)	Thioredoxin-like domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Thiol:disulfide interchange protein dsbC	-	-	periplasmic space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR012336	Thioredoxin-like fold	Domain
A	IPR033954	Disulphide bond isomerase, DsbC/G	Family
A	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
A	IPR018950	Disulphide bond isomerase, DsbC/G, N-terminal	Domain
A	IPR009094	Disulphide bond isomerase DsbC/G, N-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.