1T2K

Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D [auth B]	d1t2kb_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	Interferon regulatory factor	Interferon regulatory factor 3, IRF-3	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth A]	d1t2ka_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	Interferon regulatory factor	Interferon regulatory factor 3, IRF-3	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth C]	d1t2kc1	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	C-jun	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth C]	d1t2kc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth D]	d1t2kd_	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	Cyclic-AMP-dependent transcription factor ATF-2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth B]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057688	3000034	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057688	3000034	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	Leucine zipper-like	8032289	3001609	SCOP2B (2022-06-29)
F [auth D]	SCOP2 Family	Leucine zipper domain	8029999	4003836	SCOP2 (2022-06-29)
F [auth D]	SCOP2 Superfamily	Leucine zipper-like	8042378	3001609	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth B]	PF00605	e1t2kB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00605	ECOD (1.6)
C [auth A]	PF00605	e1t2kA1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00605	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D [auth B]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
C [auth A]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
E [auth C]	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
F [auth D]	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth B]	PF00605	Interferon regulatory factor transcription factor (IRF)	Interferon regulatory factor transcription factor	This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.	Domain
E [auth C]	PF00170	bZIP transcription factor (bZIP_1)	bZIP transcription factor	-	Coiled-coil
F [auth D]	PF00170	bZIP transcription factor (bZIP_1)	bZIP transcription factor	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E]	31-MER	-	-	-
B [auth F]	31-MER	-	-	-
C [auth A], D [auth B]	Interferon regulatory factor 3	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity sequence-specific double-stranded DNA binding double-stranded DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity sequence-specific double-stranded DNA binding double-stranded DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding protein binding protein domain specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein homodimerization activity protein dimerization activity	cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response cellular process activation of immune response cellular response to stress DNA damage response apoptotic process cell death programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of cell communication response to organic substance positive regulation of signal transduction regulation of type I interferon-mediated signaling pathway response to cytokine regulation of signal transduction interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus regulation of response to cytokine stimulus response to chemical response to type I interferon positive regulation of type I interferon-mediated signaling pathway positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cellular response to organic substance positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway cellular response to chemical stimulus type I interferon-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA transcription mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process organic cyclic compound metabolic process DNA-templated transcription nucleic acid biosynthetic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process MDA-5 signaling pathway defense response to virus response to virus multicellular organismal process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of biosynthetic process positive regulation of type I interferon production type I interferon production regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process regulation of type I interferon production regulation of primary metabolic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription regulation of RNA biosynthetic process positive regulation of RNA biosynthetic process interferon-alpha production regulation of interferon-alpha production positive regulation of interferon-alpha production positive regulation of canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction immune response-regulating cell surface receptor signaling pathway cell surface toll-like receptor signaling pathway immune response-activating cell surface receptor signaling pathway innate immune response activating cell surface receptor signaling pathway cell surface pattern recognition receptor signaling pathway toll-like receptor 4 signaling pathway response to lipid cellular response to lipopolysaccharide lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to lipid response to molecule of bacterial origin cellular response to nitrogen compound cellular response to dsRNA cellular response to exogenous dsRNA cellular response to organic cyclic compound response to dsRNA response to nitrogen compound response to exogenous dsRNA response to organic cyclic compound toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway regulation of interferon-beta production interferon-beta production positive regulation of interferon-beta production antiviral innate immune response regulation of inflammatory response inflammatory response programmed necrotic cell death macrophage apoptotic process myeloid cell apoptotic process leukocyte apoptotic process inflammatory cell apoptotic process cellular response to virus	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle mitochondrion intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle mitochondrion intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
E [auth C]	Transcription factor AP-1	SMAD binding protein binding binding R-SMAD binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding cAMP response element binding organic cyclic compound binding SMAD binding protein binding binding R-SMAD binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding cAMP response element binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding transcription factor binding general transcription initiation factor binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA binding	regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process ncRNA metabolic process positive regulation of cellular biosynthetic process regulation of miRNA transcription viral gene expression biological process involved in interspecies interaction between organisms modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription positive regulation by host of viral transcription biological process involved in symbiotic interaction cellular response to stimulus response to stimulus signaling integrated stress response signaling intracellular signal transduction cell communication cellular response to stress response to stress intracellular signaling cassette signal transduction negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process cellular response to inorganic substance cellular response to metal ion response to cadmium ion response to inorganic substance cellular response to chemical stimulus response to metal ion response to chemical cellular response to cadmium ion positive regulation of transcription by RNA polymerase II cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cell surface receptor signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway response to endoplasmic reticulum stress negative regulation by host of viral transcription latent virus replication viral latency release from viral latency regulation of vascular associated smooth muscle cell proliferation cell population proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress SMAD protein signal transduction regulation of DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation DNA-templated transcription initiation regulation of molecular function regulation of DNA binding regulation of binding negative regulation of binding negative regulation of molecular function negative regulation of DNA binding cell cycle regulation of cell cycle	protein-containing complex transcription regulator complex intracellular organelle intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen protein-containing complex transcription regulator complex intracellular organelle intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen nuclear lumen RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription factor AP-1 complex nucleoplasm euchromatin
F [auth D]	Cyclic-AMP-dependent transcription factor ATF-2	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding cAMP response element binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding catalytic activity, acting on a protein DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding cAMP response element binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone H2B acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding transcription factor binding cAMP response element binding protein binding DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein heterodimerization activity protein dimerization activity protein homodimerization activity kinase binding enzyme binding protein kinase binding LRR domain binding protein domain specific binding leucine zipper domain binding histone H4 acetyltransferase activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process regulation of cellular process signaling biological regulation p38MAPK cascade intracellular signal transduction cell communication intracellular signaling cassette cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process regulation of cellular process signaling biological regulation p38MAPK cascade intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription transcription by RNA polymerase II chromatin organization organic substance biosynthetic process positive regulation of macromolecule metabolic process transcription initiation at RNA polymerase II promoter cellular metabolic process regulation of cellular metabolic process primary metabolic process regulation of gene expression organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process protein-DNA complex organization cellular component organization RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process chromatin remodeling cellular component organization or biogenesis positive regulation of cellular process regulation of biosynthetic process protein-containing complex organization epigenetic regulation of gene expression regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of cellular biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process developmental process anatomical structure development brainstem development multicellular organismal process connective tissue development cellular developmental process developmental growth endochondral bone morphogenesis organ growth multicellular organism development skeletal system development chondrocyte differentiation involved in endochondral bone morphogenesis cell differentiation growth plate cartilage development endochondral bone growth animal organ morphogenesis bone development system development animal organ development growth tissue development anatomical structure morphogenesis growth plate cartilage chondrocyte differentiation bone growth chondrocyte differentiation skeletal system morphogenesis cartilage development involved in endochondral bone morphogenesis bone morphogenesis cartilage development positive regulation of DNA-binding transcription factor activity regulation of primary metabolic process positive regulation of molecular function regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription organonitrogen compound metabolic process protein phosphorylation phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein metabolic process protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport regulation of transforming growth factor beta production regulation of transforming growth factor beta2 production positive regulation of transforming growth factor beta2 production cytokine production regulation of cytokine production regulation of multicellular organismal process transforming growth factor beta production transforming growth factor beta2 production positive regulation of multicellular organismal process positive regulation of transforming growth factor beta production positive regulation of cytokine production response to oxidative stress cellular response to chemical stimulus response to chemical cellular response to oxidative stress cellular response to chemical stress growth plate cartilage chondrocyte proliferation cell population proliferation embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development JNK cascade mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process DNA damage checkpoint signaling regulation of cell cycle phase transition negative regulation of biological process negative regulation of cell cycle cell cycle phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition cell cycle mitotic intra-S DNA damage checkpoint signaling regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling mitotic cell cycle process signal transduction in response to DNA damage negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process fat cell differentiation white fat cell differentiation hepaticobiliary system development gland development liver development adipose tissue development cellular response to BMP stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus cell surface receptor signaling pathway response to endogenous stimulus cellular response to endogenous stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor BMP signaling pathway enzyme-linked receptor protein signaling pathway apoptotic process involved in development apoptotic process cell death programmed cell death neuron apoptotic process motor neuron apoptotic process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation alpha-beta T cell differentiation T cell activation immune system process alpha-beta T cell activation NK T cell differentiation T cell differentiation leukocyte differentiation response to nutrient levels cellular response to leucine starvation cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels response to amino acid starvation response to starvation cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels intrinsic apoptotic signaling pathway response to decreased oxygen levels apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to hypoxia response to hypoxia response to oxygen levels response to abiotic stimulus detection of stimulus detection of cell density detection of biotic stimulus response to biotic stimulus pons development head development brain development nervous system development central nervous system development metencephalon development facial nucleus development hindbrain development neural nucleus development positive regulation of myoblast proliferation myoblast proliferation positive regulation of cell population proliferation regulation of myoblast proliferation regulation of cardiac muscle myoblast proliferation positive regulation of cardiac muscle myoblast proliferation regulation of cell population proliferation cardiac muscle myoblast proliferation cellular lipid metabolic process lipid metabolic process abducens nucleus development hepatocyte apoptotic process epithelial cell apoptotic process hypoglossal nucleus development medulla oblongata development positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process regulation of protein metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of developmental process angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process hematopoietic progenitor cell differentiation response to organic substance response to organic cyclic compound apoptotic mitochondrial changes mitochondrial outer membrane permeabilization involved in programmed cell death mitochondrial membrane organization positive regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability regulation of biological quality regulation of mitochondrial membrane permeability mitochondrial transport mitochondrion organization membrane organization organelle organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process vacuole organization intermediate filament-based process neurofilament cytoskeleton organization cytoskeleton organization intermediate filament cytoskeleton organization response to osmotic stress cellular response to nitrogen compound cellular response to anisomycin response to organonitrogen compound response to nitrogen compound cellular response to organonitrogen compound response to anisomycin cellular response to organic substance cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus heart development heart morphogenesis outflow tract morphogenesis	protein-containing complex intracellular anatomical structure catalytic complex protein-DNA complex chromatin chromosome transferase complex cellular anatomical entity histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex protein-DNA complex chromatin chromosome transferase complex cellular anatomical entity histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein acetyltransferase complex intracellular protein-containing complex non-membrane-bounded organelle cytoplasm membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane RNA polymerase II transcription regulator complex nucleus nuclear protein-containing complex transcription regulator complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen site of double-strand break site of DNA damage

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth B]	IPR019817	Interferon regulatory factor, conserved site	Conserved Site
C [auth A], D [auth B]	IPR019471	Interferon regulatory factor-3	Domain
C [auth A], D [auth B]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR017855	SMAD-like domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR001346	Interferon regulatory factor, DNA-binding domain	Domain
C [auth A], D [auth B]	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
E [auth C]	IPR002112	Transcription factor Jun	Family
E [auth C]	IPR004827	Basic-leucine zipper domain	Domain
E [auth C]	IPR008917	Transcription factor, Skn-1-like, DNA-binding domain superfamily	Homologous Superfamily
E [auth C]	IPR005643	Jun-like transcription factor	Domain
E [auth C]	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily
F [auth D]	IPR013087	Zinc finger C2H2-type	Domain
F [auth D]	IPR016378	Transcription factor cyclic AMP-dependent, CRE-BP1-type	Family
F [auth D]	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
F [auth D]	IPR004827	Basic-leucine zipper domain	Domain
F [auth D]	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A], D [auth B]	Pharos: Q14653	herpes simplex encephalitis, susceptibility to, 7 Hashimoto thyroiditis Hodgkins lymphoma microphthalmia with limb anomalies rheumatoid arthritis systemic sclerosis Herpes encephalitis hypothyroidism myositis skin basal cell carcinoma vitiligo herpes simplex encephalitis influenza pancreatic ductal adenocarcinoma systemic lupus erythematosus
E [auth C]	Pharos: P05412	osteosarcoma angiosarcoma status epilepticus malignant colon neoplasm breast carcinoma peripheral nervous system disease gastric cancer hypertensive disorder breast cancer liver cancer peripheral neuropathy extrahepatic cholestasis hepatocellular carcinoma brain ischemia cancer osteosarcoma angiosarcoma status epilepticus malignant colon neoplasm breast carcinoma peripheral nervous system disease gastric cancer hypertensive disorder breast cancer liver cancer peripheral neuropathy extrahepatic cholestasis hepatocellular carcinoma brain ischemia cancer Heat Stroke juvenile idiopathic arthritis liver disease lung cancer colonic neoplasm exocrine pancreatic carcinoma pituitary cancer glioblastoma acute myeloid leukemia schizophrenia hematologic disease malignant pancreatic neoplasm type 2 diabetes mellitus medulloblastoma atypical teratoid rhabdoid tumor benign colon neoplasm ischemia reperfusion injury Minamata disease brain injury nephrosclerosis non-small cell lung carcinoma breast fibroadenoma liver neoplasm ovarian cancer lung carcinoma lymphatic system disease psoriasis gastric carcinoma rheumatoid arthritis adenoma silicosis arthritic joint disease inborn carbohydrate metabolic disorder autoimmune disease intestinal polyp myopathy neurodegenerative disease obesity disorder lung benign neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cerebrovascular disorder lung disease fetal methylmercury syndrome lymphoplasmacytic lymphoma pterygium gastric neoplasm malignant mesothelioma sarcoma amyotrophic lateral sclerosis tuberculosis hereditary diffuse gastric adenocarcinoma astrocytic tumor B-cell chronic lymphocytic leukemia large cell medulloblastoma breast disease
F [auth D]	Pharos: P15336	cancer atypical teratoid rhabdoid tumor Disease Exacerbation osteosarcoma benign neoplasm medulloblastoma ovarian cancer large cell medulloblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.