1SZP

A Crystal Structure of the Rad51 Filament

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1szpa1	All alpha proteins	SAM domain-like	Rad51 N-terminal domain-like	DNA repair protein Rad51, N-terminal domain	DNA repair protein Rad51, N-terminal domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
A	d1szpa2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	DNA repair protein Rad51, catalytic domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d1szpc1	All alpha proteins	SAM domain-like	Rad51 N-terminal domain-like	DNA repair protein Rad51, N-terminal domain	DNA repair protein Rad51, N-terminal domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d1szpc2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	DNA repair protein Rad51, catalytic domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
D	d1szpd1	All alpha proteins	SAM domain-like	Rad51 N-terminal domain-like	DNA repair protein Rad51, N-terminal domain	DNA repair protein Rad51, N-terminal domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
D	d1szpd2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	DNA repair protein Rad51, catalytic domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
E	d1szpe1	All alpha proteins	SAM domain-like	Rad51 N-terminal domain-like	DNA repair protein Rad51, N-terminal domain	DNA repair protein Rad51, N-terminal domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
E	d1szpe2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	DNA repair protein Rad51, catalytic domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
F	d1szpf1	All alpha proteins	SAM domain-like	Rad51 N-terminal domain-like	DNA repair protein Rad51, N-terminal domain	DNA repair protein Rad51, N-terminal domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
F	d1szpf2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	DNA repair protein Rad51, catalytic domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d1szpb1	All alpha proteins	SAM domain-like	Rad51 N-terminal domain-like	DNA repair protein Rad51, N-terminal domain	DNA repair protein Rad51, N-terminal domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d1szpb2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	DNA repair protein Rad51, catalytic domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Rad51 N-terminal domain-like	8056636	4001033	SCOP2 (2022-06-29)
A	SCOP2 Family	RecA/Rad51/KaiC-like ATPases	8056638	4004007	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Helix-hairpin-helix tandem	8056637	3000163	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RecA-like P-loop NTPases	8056639	3002019	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Helix-hairpin-helix tandem	8056637	3000163	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RecA-like P-loop NTPases	8056639	3002019	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Helix-hairpin-helix tandem	8056637	3000163	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RecA-like P-loop NTPases	8056639	3002019	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	RecA-like P-loop NTPases	8056639	3002019	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Helix-hairpin-helix tandem	8056637	3000163	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Helix-hairpin-helix tandem	8056637	3000163	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	RecA-like P-loop NTPases	8056639	3002019	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Helix-hairpin-helix tandem	8056637	3000163	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RecA-like P-loop NTPases	8056639	3002019	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HHH_5	e1szpA1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: HHH_5	ECOD (1.6)
A	RecA	e1szpA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
C	HHH_5	e1szpC3	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: HHH_5	ECOD (1.6)
C	RecA	e1szpC4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
D	HHH_5	e1szpD1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: HHH_5	ECOD (1.6)
D	RecA	e1szpD2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
E	HHH_5	e1szpE1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: HHH_5	ECOD (1.6)
E	RecA	e1szpE2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
F	HHH_5	e1szpF1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: HHH_5	ECOD (1.6)
F	RecA	e1szpF2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
B	HHH_5	e1szpB3	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: HHH_5	ECOD (1.6)
B	RecA	e1szpB4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.150.20	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	1.10.150.20	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
D	1.10.150.20	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
D	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
E	1.10.150.20	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
E	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
F	1.10.150.20	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
F	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	1.10.150.20	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF08423	Rad51 (Rad51)	Rad51	Rad51 is a DNA repair and recombination protein and is a homologue of the bacterial ATPase RecA protein.	Domain
A, B, C, D, E A, B, C, D, E, F	PF14520	Helix-hairpin-helix domain (HHH_5)	Helix-hairpin-helix domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	DNA repair protein RAD51	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA strand exchange activity DNA damage sensor activity small molecule sensor activity ATP-dependent DNA damage sensor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA strand exchange activity DNA damage sensor activity small molecule sensor activity ATP-dependent DNA damage sensor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding double-stranded DNA binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides identical protein binding protein binding single-stranded DNA binding	sexual reproduction reproductive process meiotic cell cycle chromosome organization meiotic cell cycle process cellular component organization chromosome organization involved in meiotic cell cycle organelle organization cellular process cellular component organization or biogenesis cell cycle cell cycle process homologous recombination nucleobase-containing compound metabolic process sexual reproduction reproductive process meiotic cell cycle chromosome organization meiotic cell cycle process cellular component organization chromosome organization involved in meiotic cell cycle organelle organization cellular process cellular component organization or biogenesis cell cycle cell cycle process homologous recombination nucleobase-containing compound metabolic process organic substance metabolic process meiosis I meiotic nuclear division reciprocal homologous recombination DNA recombination organelle fission primary metabolic process DNA metabolic process nucleic acid metabolic process reciprocal meiotic recombination organic cyclic compound metabolic process nuclear division meiosis I cell cycle process metabolic process macromolecule metabolic process mitotic recombination telomere organization telomere maintenance telomere maintenance via recombination heteroduplex formation meiotic joint molecule formation DNA strand invasion mitotic DNA replication DNA-templated DNA replication maintenance of fidelity nuclear DNA replication cell cycle DNA replication mitotic cell cycle cell cycle DNA replication maintenance of fidelity DNA-templated DNA replication DNA replication mitotic cell cycle process mitotic recombination-dependent replication fork processing mitotic DNA replication maintenance of fidelity replication fork processing cellular response to stimulus double-strand break repair response to stimulus cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair nucleotide-excision repair mitochondrial genome maintenance mitochondrial DNA metabolic process mitochondrial DNA repair mitochondrion organization cellular component biogenesis protein-DNA complex organization DNA recombinase assembly cellular component assembly protein-containing complex assembly DNA repair complex assembly protein-containing complex organization protein-DNA complex assembly double-strand break repair via synthesis-dependent strand annealing	membrane-bounded organelle condensed nuclear chromosome intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle membrane-bounded organelle condensed nuclear chromosome intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle condensed chromosome non-membrane-bounded organelle nuclear lumen mitochondrion mitochondrial matrix cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR013632	DNA recombination and repair protein Rad51-like, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR020587	DNA recombination and repair protein RecA, monomer-monomer interface	Domain
A, B, C, D, E A, B, C, D, E, F	IPR003593	AAA+ ATPase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR011941	DNA recombination/repair protein Rad51	Family
A, B, C, D, E A, B, C, D, E, F	IPR016467	DNA recombination and repair protein, RecA-like	Family
A, B, C, D, E A, B, C, D, E, F	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR010995	DNA repair Rad51/transcription factor NusA, alpha-helical	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.