1STD

CRYSTAL STRUCTURE OF SCYTALONE DEHYDRATASE: A DISEASE DETERMINANT OF THE RICE PATHOGEN, MAGNAPORTHE GRISEA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1stda_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Scytalone dehydratase	Scytalone dehydratase	(Pyricularia grisea ) [TaxId: 148305 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	NTF2-like	8044551	3000472	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Scytalone_dh	e1stdA1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: Scytalone_dh	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02982	Scytalone dehydratase (Scytalone_dh)	Scytalone dehydratase	Scytalone dehydratases are structurally related to the NTF2 family (see Pfam:PF02136).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SCYTALONE DEHYDRATASE	cation binding ion binding binding metal ion binding small molecule binding scytalone dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity	pigment metabolic process organic hydroxy compound metabolic process pigment biosynthetic process melanin metabolic process secondary metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process secondary metabolite biosynthetic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process phenol-containing compound biosynthetic process pigment metabolic process organic hydroxy compound metabolic process pigment biosynthetic process melanin metabolic process secondary metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process secondary metabolite biosynthetic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process phenol-containing compound biosynthetic process metabolic process melanin biosynthetic process	membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A	IPR004235	Scytalone dehydratase	Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	scytalone dehydratase M-CSA #910	Scytalone dehydratase (SD) catalySes the dehydrations of scytalone and vermelone in the fungal melanin biosynthetic pathway. It was first identified in a phytopathogenic fungus, Magnaporthe grisea (Rice blast fungus), which causes rice blast disease. Scytalone dehydratase is a molecular target of inhibitor design efforts aimed at protecting rice plants from fungal disease [PMID:9922139, PMID:14716498].	Defined by 5 residues: TYR:A-30ASP:A-31TYR:A-50HIS:A-85HIS:A-110 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 4.2.1.94 (PDB Primary Data) Search M-CSA Motif + EC 4.2.1.94

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.