Annotations: 1SRS

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1srsa_	Alpha and beta proteins (a+b)	SRF-like	SRF-like	SRF-like	Serum response factor (SRF) core	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth B]	d1srsb_	Alpha and beta proteins (a+b)	SRF-like	SRF-like	SRF-like	Serum response factor (SRF) core	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	SRF-like	8023006	4001594	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	SRF-like	8035386	3001928	SCOP2 (2022-06-29)
D [auth B]	SCOP2B Superfamily	SRF-like	8035386	3001928	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	SRF-TF	e1srsA1	A: a+b three layers	X: SRF-like (From Topology)	H: SRF-like (From Topology)	T: SRF-like	F: SRF-TF	ECOD (1.6)
D [auth B]	SRF-TF	e1srsB1	A: a+b three layers	X: SRF-like (From Topology)	H: SRF-like (From Topology)	T: SRF-like	F: SRF-TF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	3.40.1810.10	Alpha Beta	3-Layer(aba) Sandwich	SRF-like	Transcription factor, MADS-box	CATH (4.3.0)
D [auth B]	3.40.1810.10	Alpha Beta	3-Layer(aba) Sandwich	SRF-like	Transcription factor, MADS-box	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth B]	PF00319	SRF-type transcription factor (DNA-binding and dimerisation domain) (SRF-TF)	SRF-type transcription factor (DNA-binding and dimerisation domain)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth W]	DNA (5'-D(CPCP(5IU)PTPCPCPTPAPAPTPTPAPGPGPCPCPAPTP*G)-3')	-	-	-
B [auth C]	DNA (5'-D(CPCPAPTPGPGPCPCPTPAPAPTPTPAPGPGPA PAP*G)-3')	-	-	-
C [auth A], D [auth B]	PROTEIN (SERUM RESPONSE FACTOR (SRF))	histone deacetylase binding protein binding binding enzyme binding DNA binding sequence-specific DNA binding serum response element binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding histone deacetylase binding protein binding binding enzyme binding DNA binding sequence-specific DNA binding serum response element binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA binding primary miRNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding identical protein binding protein homodimerization activity protein dimerization activity protein-containing complex binding chromatin binding chromatin DNA binding	developmental process multicellular organismal process trachea cartilage development connective tissue development animal organ development tissue development multicellular organism development skeletal system development trachea development anatomical structure development respiratory system development system development cartilage development head development developmental process multicellular organismal process trachea cartilage development connective tissue development animal organ development tissue development multicellular organism development skeletal system development trachea development anatomical structure development respiratory system development system development cartilage development head development forebrain development olfactory lobe development brain development nervous system development tangential migration from the subventricular zone to the olfactory bulb telencephalon cell migration central nervous system development forebrain cell migration cell migration cellular process telencephalon development cell motility olfactory bulb development regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation heart development circulatory system development tissue morphogenesis anatomical structure morphogenesis epithelium development morphogenesis of an epithelium morphogenesis of an epithelial sheet cell-cell adhesion epithelial cell-cell adhesion tube development respiratory tube development lung morphogenesis lung development animal organ morphogenesis erythrocyte development cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation myeloid cell development homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis lung smooth muscle development smooth muscle tissue development muscle tissue development establishment of skin barrier skin development skin epidermis development epidermis development positive regulation of DNA-binding transcription factor activity cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process smooth muscle cell differentiation regulation of developmental process regulation of smooth muscle cell differentiation regulation of cell differentiation muscle cell differentiation muscle structure development regulation of muscle cell differentiation actomyosin structure organization actin cytoskeleton organization actin filament organization cellular component organization cellular component biogenesis organelle organization cellular component assembly actin filament bundle organization contractile actin filament bundle assembly actin filament-based process actin filament bundle assembly stress fiber assembly cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization axon extension positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron differentiation neuron projection morphogenesis positive regulation of cell projection organization regulation of biological quality positive regulation of developmental growth regulation of cell projection organization positive regulation of cell development developmental growth involved in morphogenesis generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization plasma membrane bounded cell projection morphogenesis positive regulation of biological process cell growth cell morphogenesis regulation of axon extension regulation of nervous system development neurogenesis regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension positive regulation of cellular process positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size cell migration involved in sprouting angiogenesis endothelial cell migration angiogenesis tube morphogenesis tissue migration ameboidal-type cell migration blood vessel endothelial cell migration epithelial cell migration blood vessel development blood vessel morphogenesis sprouting angiogenesis vasculature development epithelium migration anatomical structure formation involved in morphogenesis response to stimulus response to chemical response to toxic substance cellular response to stimulus cellular response to stress response to stress cellular senescence positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process miRNA transcription positive regulation of biosynthetic process positive regulation of RNA biosynthetic process ncRNA metabolic process positive regulation of cellular biosynthetic process regulation of miRNA transcription bicellular tight junction assembly tight junction organization apical junction assembly cell junction organization cell junction assembly tight junction assembly cell-cell junction assembly cell-cell junction organization regulation of body fluid levels wound healing cell activation hemostasis blood coagulation coagulation response to wounding platelet activation branching morphogenesis of an epithelial tube epithelial tube morphogenesis branching involved in blood vessel morphogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium negative regulation of locomotion regulation of cell motility negative regulation of biological process regulation of locomotion negative regulation of cellular process regulation of cell migration negative regulation of cell motility negative regulation of cell migration locomotion response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus skin morphogenesis angiogenesis involved in wound healing transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II response to organic substance response to hormone response to endogenous stimulus heart morphogenesis pattern specification process embryo development embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry embryonic organ development determination of left/right symmetry specification of symmetry embryonic organ morphogenesis embryonic morphogenesis determination of heart left/right asymmetry regionalization left/right pattern formation face development formation of primary germ layer mesoderm morphogenesis gastrulation mesoderm formation mesoderm development cellular homeostasis muscle cell cellular homeostasis primitive streak formation anterior/posterior pattern specification anterior/posterior axis specification gastrulation with mouth forming second axis specification bronchus development bronchus cartilage development cell-matrix adhesion cell-substrate adhesion pallium development hippocampus development limbic system development megakaryocyte differentiation megakaryocyte development immune system development gland development hematopoietic or lymphoid organ development thymus development thyroid gland development endocrine system development response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular response to chemical stimulus chemical homeostasis response to glucose glucose homeostasis thymic T cell selection mononuclear cell differentiation lymphocyte activation lymphocyte differentiation positive thymic T cell selection leukocyte activation T cell differentiation in thymus T cell activation positive T cell selection T cell differentiation T cell selection leukocyte differentiation carbon catabolite regulation of transcription positive regulation of transcription by glucose cellular response to nutrient levels carbon catabolite activation of transcription response to nutrient levels response to nutrient cellular response to nutrient regulation of transcription by glucose response to cytokine cardiac chamber morphogenesis heart trabecula formation cardiac chamber development heart trabecula morphogenesis trabecula formation trabecula morphogenesis trophectodermal cell differentiation chordate embryonic development in utero embryonic development blastocyst formation embryo development ending in birth or egg hatching blastocyst development cardiac vascular smooth muscle cell differentiation coronary vasculature development cardiocyte differentiation vascular associated smooth muscle cell differentiation behavior system process learning or memory long-term memory nervous system process cognition memory negative regulation of miRNA transcription negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process negative regulation of miRNA metabolic process regulation of DNA-templated transcription initiation transcription initiation at RNA polymerase II promoter positive regulation of DNA-templated transcription initiation positive regulation of transcription initiation by RNA polymerase II DNA-templated transcription initiation regulation of transcription initiation by RNA polymerase II stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation platelet morphogenesis platelet formation filopodium assembly plasma membrane bounded cell projection assembly cell projection assembly negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation positive regulation of smooth muscle contraction regulation of system process muscle contraction muscle system process regulation of muscle system process smooth muscle contraction regulation of muscle contraction regulation of smooth muscle contraction positive regulation of muscle contraction cardiac muscle cell development cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly striated muscle tissue development striated muscle cell development cellular anatomical entity morphogenesis muscle cell development cardiac cell development organelle assembly cardiac muscle tissue development cardiac muscle cell differentiation myofibril assembly cardiac myofibril assembly striated muscle cell differentiation learning associative learning regulation of filopodium assembly positive regulation of filopodium assembly positive regulation of cellular component biogenesis regulation of cell projection assembly regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly positive regulation of plasma membrane bounded cell projection assembly negative regulation of signaling signaling modulation of chemical synaptic transmission negative regulation of synaptic transmission negative regulation of cell communication cell communication synaptic signaling regulation of synaptic plasticity trans-synaptic signaling regulation of signaling cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling long-term synaptic depression anterograde trans-synaptic signaling regulation of cell communication cardiac muscle cell myoblast differentiation cardioblast differentiation myoblast differentiation neuron migration negative regulation of amyloid-beta clearance amyloid-beta clearance regulation of amyloid-beta clearance negative regulation of multicellular organismal process eyelid development in camera-type eye sensory organ development eye development visual system development camera-type eye development sensory system development epithelial structure maintenance anatomical structure homeostasis tissue homeostasis sarcomere organization aorta morphogenesis artery development aorta development dorsal aorta morphogenesis artery morphogenesis dorsal aorta development	intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth B]	IPR033897	MADS SRF-like	Domain
C [auth A], D [auth B]	IPR036879	Transcription factor, MADS-box superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR002100	Transcription factor, MADS-box	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A], D [auth B]	Pharos: P11831	HIV infectious disease cancer benign neoplasm fetal alcohol spectrum disorder ovarian cancer breast cancer fetal alcohol syndrome Neoplasms psoriasis osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.