Annotations: 1SRK

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1srka1	Small proteins	beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	Classic zinc finger, C2H2	Zinc finger protein ZFPM1 (FOG-1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1srka2	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Classic zinc finger C2H2	8027366	4003583	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	beta-beta-alpha zinc fingers	8039745	3001077	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e1srkA1	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Zinc finger protein ZFPM1	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding DNA binding organic cyclic compound binding nucleic acid binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cation binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding DNA binding organic cyclic compound binding nucleic acid binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cation binding ion binding metal ion binding small molecule binding	developmental process heart development multicellular organismal process atrioventricular valve development heart valve development animal organ development tricuspid valve formation circulatory system development multicellular organism development anatomical structure morphogenesis tricuspid valve development atrioventricular valve formation heart valve morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis developmental process heart development multicellular organismal process atrioventricular valve development heart valve development animal organ development tricuspid valve formation circulatory system development multicellular organism development anatomical structure morphogenesis tricuspid valve development atrioventricular valve formation heart valve morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis heart valve formation tricuspid valve morphogenesis atrioventricular valve morphogenesis system development regulation of cellular process cellular developmental process regulation of developmental process homeostatic process cell development regulation of cell differentiation regulation of cell development cell differentiation regulation of immune system process regulation of multicellular organismal process myeloid cell homeostasis erythrocyte homeostasis regulation of biological process regulation of multicellular organismal development definitive hemopoiesis hemopoiesis regulation of myeloid cell differentiation biological regulation regulation of definitive erythrocyte differentiation erythrocyte differentiation definitive erythrocyte differentiation regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process regulation of hemopoiesis homeostasis of number of cells cellular process megakaryocyte differentiation megakaryocyte development myeloid cell development cardiac chamber morphogenesis heart morphogenesis ventricular septum development cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding negative regulation of molecular function cardiac atrium morphogenesis cardiac atrium development atrial septum morphogenesis atrial septum development cardiac muscle tissue development tissue development muscle tissue morphogenesis striated muscle tissue development muscle structure development tissue morphogenesis cardiac muscle tissue morphogenesis muscle organ development muscle tissue development muscle organ morphogenesis primitive hemopoiesis embryo development embryonic organ development embryonic hemopoiesis primitive erythrocyte differentiation myeloid leukocyte differentiation granulocyte differentiation leukocyte differentiation mitral valve morphogenesis mitral valve development mitral valve formation regulation of leukocyte differentiation negative regulation of mast cell differentiation negative regulation of biological process negative regulation of cellular process negative regulation of cell differentiation negative regulation of hemopoiesis regulation of mast cell differentiation negative regulation of leukocyte differentiation negative regulation of developmental process regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development negative regulation of immune system process mast cell differentiation negative regulation of multicellular organismal process regulation of interleukin-4 production cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of interleukin-4 production organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process interleukin-4 production negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process platelet morphogenesis cell morphogenesis platelet formation regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II primary metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of type II interferon production type II interferon production positive regulation of type II interferon production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production regulation of chemokine production chemokine production outflow tract morphogenesis	protein-containing complex transcription regulator complex transcription repressor complex membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013087	Zinc finger C2H2-type	Domain
A	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
A	IPR049361	Zinc finger protein ZFPM1/2, PR domain	Domain
A	IPR039746	FOG family	Family
A	IPR034731	Zinc finger CCHC FOG-type	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.