1SMR

The 3-d structure of mouse submaxillary renin complexed with a decapeptide inhibitor ch-66 based on the 4-16 fragment of rat angiotensinogen

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1smra_	All beta proteins	Acid proteases	Acid proteases	Pepsin-like	Chymosin (synonym: renin)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d1smrc_	All beta proteins	Acid proteases	Acid proteases	Pepsin-like	Chymosin (synonym: renin)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d1smre_	All beta proteins	Acid proteases	Acid proteases	Pepsin-like	Chymosin (synonym: renin)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d1smrg_	All beta proteins	Acid proteases	Acid proteases	Pepsin-like	Chymosin (synonym: renin)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Pepsin-like	8030117	4002301	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Acid proteases	8042496	3001059	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Acid proteases	8042496	3001059	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Acid proteases	8042496	3001059	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Acid proteases	8042496	3001059	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00026	e1smrA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF00026	ECOD (1.6)
C	PF00026	e1smrC3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF00026	ECOD (1.6)
E	PF00026	e1smrE3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF00026	ECOD (1.6)
G	PF00026	e1smrG3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF00026	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
C	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
E	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
G	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF00026	Eukaryotic aspartyl protease (Asp)	Eukaryotic aspartyl protease	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	RENIN	aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity aspartic-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding signaling receptor binding insulin-like growth factor receptor binding	regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process cellular biosynthetic process signaling receptor ligand precursor processing protein maturation organic substance metabolic process circulatory system process proteolysis organic substance biosynthetic process amide metabolic process regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process cellular biosynthetic process signaling receptor ligand precursor processing protein maturation organic substance metabolic process circulatory system process proteolysis organic substance biosynthetic process amide metabolic process protein metabolic process regulation of biological quality blood circulation organonitrogen compound metabolic process regulation of blood pressure regulation of hormone levels cellular metabolic process biological regulation regulation of systemic arterial blood pressure by circulatory renin-angiotensin primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process regulation of systemic arterial blood pressure endocrine process biosynthetic process regulation of angiotensin levels in blood protein processing metabolic process cellular process macromolecule metabolic process angiotensin maturation response to stimulus response to chemical response to xenobiotic stimulus response to organic substance response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to cGMP response to purine-containing compound response to organic cyclic compound positive regulation of blood pressure cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process signaling regulation of signal transduction regulation of MAPK cascade intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette MAPK cascade regulation of cell communication signal transduction response to cAMP developmental process multicellular organism development anatomical structure development animal organ development kidney development renal system development system development	apical part of cell cellular anatomical entity extracellular region extracellular space
B, D, F, H	INHIBITOR CH-66	angiotensin receptor binding protein binding binding signaling receptor binding type 1 angiotensin receptor binding G protein-coupled receptor binding type 2 angiotensin receptor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity angiotensin receptor binding protein binding binding signaling receptor binding type 1 angiotensin receptor binding G protein-coupled receptor binding type 2 angiotensin receptor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity hormone activity molecular function activator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process regulation of cellular process cellular metabolic process reactive oxygen species metabolic process regulation of superoxide metabolic process regulation of cellular metabolic process positive regulation of cellular metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process superoxide anion generation cellular process positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of reactive oxygen species metabolic process positive regulation of cellular process response to stimulus response to stress response to abiotic stimulus response to cold response to temperature stimulus regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process regulation of blood volume by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal system process regulation of blood pressure regulation of systemic arterial blood pressure circulatory system process endocrine process regulation of renal output by angiotensin regulation of biological quality blood circulation cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization regulation of localization regulation of cellular component organization positive regulation of cellular component organization transport positive regulation of extracellular matrix constituent secretion positive regulation of extracellular matrix organization positive regulation of secretion by cell localization regulation of secretion by cell secretion by cell positive regulation of secretion regulation of extracellular matrix constituent secretion regulation of transport secretion export from cell establishment of localization regulation of secretion positive regulation of transport extracellular matrix constituent secretion regulation of extracellular matrix organization regulation of tube diameter regulation of tube size vascular process in circulatory system blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size developmental process epithelium development endothelial cell differentiation cellular developmental process endothelium development cell development peripheral nervous system development nervous system development tissue development epithelial cell differentiation endothelial cell development multicellular organism development epithelial cell development cell differentiation anatomical structure development establishment of blood-nerve barrier system development cellular response to stimulus cellular response to growth factor stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cell communication cellular response to endogenous stimulus neurotrophin signaling pathway negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway negative regulation of signal transduction regulation of neurotrophin TRK receptor signaling pathway regulation of response to stimulus negative regulation of neurotrophin TRK receptor signaling pathway regulation of cell communication response to growth factor positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of protein modification process organic substance metabolic process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation macromolecule metabolic process import into cell nitrogen compound transport positive regulation of L-lysine import across plasma membrane carboxylic acid transmembrane transport amino acid transmembrane transport L-amino acid transport positive regulation of amine transport regulation of L-lysine import across plasma membrane positive regulation of transmembrane transport regulation of amino acid transport regulation of amino acid transmembrane transport organic acid transmembrane transport L-lysine transmembrane transport organic anion transport carboxylic acid transport organic substance transport import across plasma membrane organic cation transport positive regulation of organic acid transport transmembrane transport organic acid transport amino acid transport amine transport regulation of amino acid import across plasma membrane L-lysine transport regulation of transmembrane transport positive regulation of amino acid transport regulation of organic acid transport L-alpha-amino acid transmembrane transport regulation of amine transport amino acid import across plasma membrane L-lysine import across plasma membrane positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process regulation of miRNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of miRNA transcription regulation of aldosterone secretion regulation of system process regulation of steroid hormone secretion aldosterone secretion mineralocorticoid secretion regulation of hormone levels lipid transport regulation of corticosteroid hormone secretion endocrine hormone secretion lipid export from cell renin-angiotensin regulation of aldosterone production regulation of mineralocorticoid secretion regulation of endocrine process corticosteroid hormone secretion regulation of hormone secretion steroid hormone secretion regulation of lipid transport organic hydroxy compound transport hormone secretion signal release regulation of multicellular organismal process renal system process involved in regulation of systemic arterial blood pressure renal system process lipid localization cell-cell signaling regulation of lipid localization macromolecule localization hormone transport regulation of neuron projection development cell projection organization neuron projection development neurogenesis neuron differentiation positive regulation of neuron projection development positive regulation of cell projection organization plasma membrane bounded cell projection organization regulation of cell projection organization generation of neurons neuron development regulation of plasma membrane bounded cell projection organization fibroblast proliferation cell population proliferation astrocyte differentiation astrocyte activation glial cell development astrocyte development gliogenesis defense response cell activation central nervous system development glial cell differentiation glial cell activation inflammatory response neuroinflammatory response muscle hypertrophy regulation of muscle adaptation positive regulation of cardiac muscle hypertrophy striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process vasculature development blood vessel development circulatory system development response to osmotic stress response to salt stress regulation of vascular associated smooth muscle cell proliferation negative regulation of cell population proliferation regulation of smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation smooth muscle contraction phasic smooth muscle contraction muscle contraction peristalsis nervous system process brain renin-angiotensin system nervous system process involved in regulation of systemic arterial blood pressure positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of signaling developmental growth growth organ growth mesonephric epithelium development kidney epithelium development branching morphogenesis of an epithelial tube nephron tubule morphogenesis regulation of kidney development regulation of branching involved in ureteric bud morphogenesis positive regulation of developmental process tube morphogenesis animal organ morphogenesis nephron development regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis mesonephric tubule development renal tubule morphogenesis regulation of developmental process nephron morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis positive regulation of morphogenesis of an epithelium branching involved in ureteric bud morphogenesis renal tubule development regulation of morphogenesis of an epithelium epithelial tube morphogenesis regulation of anatomical structure morphogenesis nephron epithelium development ureteric bud development tube development mesonephros development animal organ development morphogenesis of an epithelium tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis morphogenesis of a branching structure positive regulation of branching involved in ureteric bud morphogenesis mesonephric tubule morphogenesis kidney development morphogenesis of a branching epithelium regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition regulation of cell differentiation mesenchyme development positive regulation of cell differentiation epithelial to mesenchymal transition mesenchymal cell differentiation MAPK cascade ERK1 and ERK2 cascade ovulation cycle process ovulation sexual reproduction reproductive process sex differentiation development of primary female sexual characteristics female gamete generation developmental process involved in reproduction gamete generation ovulation from ovarian follicle ovulation cycle development of primary sexual characteristics reproductive structure development rhythmic process gonad development reproductive system development female gonad development multicellular organismal reproductive process ovarian follicle rupture female sex differentiation positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component biogenesis cellular component assembly regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly extracellular matrix assembly regulation of programmed cell death extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway macrophage derived foam cell differentiation foam cell differentiation regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation positive regulation of cardiac muscle cell apoptotic process muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process positive regulation of cell population proliferation response to mechanical stimulus response to external stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus neuron apoptotic process muscle structure development smooth muscle cell differentiation muscle cell differentiation regulation of growth regulation of developmental growth positive regulation of organ growth positive regulation of growth regulation of organ growth positive regulation of developmental growth vascular associated smooth muscle contraction artery smooth muscle contraction tonic smooth muscle contraction L-arginine import across plasma membrane regulation of L-arginine import across plasma membrane positive regulation of L-arginine import across plasma membrane behavior learning learning or memory cognition associative learning cytokine production regulation of cytokine production positive regulation of gene expression positive regulation of cytokine production uterine smooth muscle contraction G protein-coupled receptor signaling pathway angiogenesis regulation of vasculature development regulation of multicellular organismal development blood vessel morphogenesis negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process operant conditioning response to organic substance response to lipid response to chemical response to estradiol response to oxygen-containing compound response to organic cyclic compound regulation of systemic arterial blood pressure by circulatory renin-angiotensin renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure heart process regulation of cardiac conduction regulation of heart contraction regulation of blood circulation cardiac conduction heart contraction regulation of heart rate feeding behavior drinking behavior angiotensin-mediated drinking behavior regulation of calcium ion transport regulation of monoatomic ion transport metal ion transport calcium ion transport monoatomic ion transport regulation of metal ion transport monoatomic cation transport gap junction assembly positive regulation of gap junction assembly cell junction assembly cell-cell junction assembly cell-cell junction organization regulation of gap junction assembly regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization negative regulation of tissue remodeling tissue remodeling regulation of tissue remodeling oxoacid metabolic process regulation of lipid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process cellular ketone metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process regulation of cellular ketone metabolic process cellular lipid metabolic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process monocarboxylic acid metabolic process lipid biosynthetic process positive regulation of fatty acid biosynthetic process positive regulation of fatty acid metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process fatty acid biosynthetic process positive regulation of lipid biosynthetic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process lipid metabolic process response to angiotensin response to hormone response to organonitrogen compound response to peptide hormone response to nitrogen compound negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth cellular response to nitrogen compound angiotensin-activated signaling pathway cellular response to angiotensin cellular response to organic substance cellular response to hormone stimulus cellular response to peptide hormone stimulus cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound protein localization establishment of protein localization cellular localization nucleocytoplasmic transport nuclear transport intracellular transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway regulation of neuronal synaptic plasticity regulation of synaptic plasticity trans-synaptic signaling regulation of long-term neuronal synaptic plasticity modulation of chemical synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling insulin receptor signaling pathway regulation of cellular response to insulin stimulus positive regulation of cellular response to insulin stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway response to insulin cellular response to insulin stimulus positive regulation of systemic arterial blood pressure positive regulation of blood pressure renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure maintenance of blood vessel diameter homeostasis by renin-angiotensin angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure cardiac muscle cell development striated muscle tissue development muscle cell development cardiac cell development muscle tissue development cardiac muscle tissue growth heart development heart growth developmental cell growth cardiac muscle tissue development physiological muscle hypertrophy cardiac muscle cell differentiation cardiocyte differentiation cell growth involved in cardiac muscle cell development physiological cardiac muscle hypertrophy striated muscle cell differentiation peptide secretion amide transport vasopressin secretion peptide transport peptide hormone secretion cell adhesion cell-matrix adhesion cell-substrate adhesion sodium ion homeostasis inorganic ion homeostasis homeostatic process intracellular sodium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis positive regulation of cytosolic calcium ion concentration positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration epithelial cell migration cell motility regulation of epithelial cell migration locomotion epithelium migration regulation of locomotion positive regulation of endothelial cell migration multi-multicellular organism process female pregnancy multi-organism reproductive process stress-activated MAPK cascade stress-activated protein kinase signaling cascade cellular response to stress response to muscle activity involved in regulation of muscle adaptation response to activity response to stimulus involved in regulation of muscle adaptation response to muscle activity regulation of fibroblast proliferation positive regulation of fibroblast proliferation hormone metabolic process positive regulation of vascular associated smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation monoamine transport regulation of catecholamine secretion catecholamine transport norepinephrine transport catecholamine secretion norepinephrine secretion regulation of norepinephrine secretion regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of neuron apoptotic process negative regulation of programmed cell death negative regulation of apoptotic process regulation of neuron apoptotic process regulation of vascular associated smooth muscle cell migration vascular associated smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of smooth muscle cell migration smooth muscle cell migration muscle cell migration positive regulation of vascular associated smooth muscle cell migration vasodilation positive regulation of MAPK cascade regulation of MAPK cascade regulation of defense response regulation of response to external stimulus regulation of inflammatory response regulation of response to stress regulation of multicellular organism growth positive regulation of multicellular organism growth multicellular organism growth transmission of nerve impulse regulation of nervous system process regulation of transmission of nerve impulse	extracellular region extracellular space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR001461	Aspartic peptidase A1 family	Family
A, C, E, G	IPR012848	Aspartic peptidase, N-terminal	Domain
A, C, E, G	IPR033121	Peptidase family A1 domain	Domain
A, C, E, G	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
A, C, E, G	IPR001969	Aspartic peptidase, active site	Active Site
A, C, E, G	IPR034135	Renin-like domain	Domain
B, D, F, H	IPR033834	Angiotensinogen, serpin domain	Domain
B, D, F, H	IPR036186	Serpin superfamily	Homologous Superfamily
B, D, F, H	IPR000227	Angiotensinogen	Family
B, D, F, H	IPR023796	Serpin domain	Domain
B, D, F, H	IPR042185	Serpin superfamily, domain 2	Homologous Superfamily
B, D, F, H	IPR000215	Serpin family	Family
B, D, F, H	IPR042178	Serpin superfamily, domain 1	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.