Annotations: 1SKZ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1skza1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Leech antihemostatic proteins	Huristasin-like	Factor Xa inhibitor antistasin	Mexican leech (Haementeria officinalis ) [TaxId: 6410 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Huristasin-like	8026002	4003247	SCOP2 (2022-06-29)
A	SCOP2 Family	Huristasin-like	8026003	4003247	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Leech antihemostatic proteins	8038381	3000489	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Leech antihemostatic proteins	8038382	3000489	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e1skzA2	A: few secondary structure elements	X: Huristasin-like (From Topology)	H: Huristasin-like (From Topology)	T: Huristasin-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF02822	e1skzA1	A: few secondary structure elements	X: Huristasin-like (From Topology)	H: Huristasin-like (From Topology)	T: Huristasin-like	F: PF02822	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.22.10	Mainly Beta	Ribbon	Antistasin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02822	Antistasin family (Antistasin)	Antistasin family	Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ANTISTASIN	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity heparin binding glycosaminoglycan binding binding carbohydrate derivative binding sulfur compound binding	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of biological process negative regulation of coagulation negative regulation of biological process multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of biological process negative regulation of coagulation negative regulation of biological process regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of coagulation	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004094	Antistasin-like domain	Domain
A	IPR008086	Proteinase inhibitor I15, leech antistasin	Family
A	IPR011061	Hirudin/antistatin	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.