Annotations: 1SKN

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth P]	d1sknp_	All alpha proteins	A DNA-binding domain in eukaryotic transcription factors	A DNA-binding domain in eukaryotic transcription factors	A DNA-binding domain in eukaryotic transcription factors	Skn-1	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth P]	SCOP2 Family	A DNA-binding domain in eukaryotic transcription factors	8024855	4000910	SCOP2 (2022-06-29)
C [auth P]	SCOP2 Superfamily	A DNA-binding domain in eukaryotic transcription factors	8037234	3001953	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth P]	PF03131	e1sknP1	A: alpha bundles	X: A DNA-binding domain in eukaryotic transcription factors (From Topology)	H: A DNA-binding domain in eukaryotic transcription factors (From Topology)	T: A DNA-binding domain in eukaryotic transcription factors	F: PF03131	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth P]	1.10.880.10	Mainly Alpha	Orthogonal Bundle	Transcription Factor Skn-1	Chain P	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth P]	PF03131	bZIP Maf transcription factor (bZIP_Maf)	bZIP Maf transcription factor	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA (5'-D(TPGPAPCPAPAPTPGPTPCPAPTPCPCP*C)-3')	-	-	-
B	DNA (5'-D(CPAPGPGPGPAPTPGPAPCPAPTPTPGP*T)-3')	-	-	-
C [auth P]	DNA-BINDING DOMAIN OF SKN-1	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding Hsp70 protein binding DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding Hsp70 protein binding protein-folding chaperone binding heat shock protein binding transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific	developmental process cellular developmental process cell differentiation cellular process cell fate specification cell fate commitment regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process developmental process cellular developmental process cell differentiation cellular process cell fate specification cell fate commitment regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process multicellular organism development multicellular organismal process digestive system development tube development anatomical structure development digestive tract development system development animal organ development embryo development embryonic organ development embryonic digestive tract development organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression protein metabolic process organonitrogen compound metabolic process regulation of protein metabolic process primary metabolic process translation regulation of translation response to oxidative stress response to stimulus response to stress response to chemical response to oxygen-containing compound response to superoxide response to reactive oxygen species response to oxygen radical response to inorganic substance biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus determination of adult lifespan cellular response to stimulus positive regulation of cellular response to oxidative stress cellular response to oxidative stress regulation of cellular response to stress cellular response to chemical stress regulation of cellular response to oxidative stress positive regulation of response to stimulus cellular response to stress regulation of response to stress regulation of response to oxidative stress positive regulation of response to oxidative stress cellular response to chemical stimulus regulation of response to stimulus cellular detoxification detoxification cellular response to toxic substance response to toxic substance defense response to Gram-negative bacterium response to organic substance response to paraquat formation of primary germ layer endodermal cell fate specification embryonic morphogenesis tissue development gastrulation cell fate commitment involved in formation of primary germ layer anatomical structure morphogenesis endoderm development anatomical structure formation involved in morphogenesis endoderm formation endodermal cell fate commitment endodermal cell differentiation cellular response to inorganic substance cellular response to metal ion cellular response to manganese ion regulation of cellular response to manganese ion response to metal ion response to manganese ion positive regulation of cellular response to manganese ion RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription mesendoderm development mesoderm development embryonic pattern specification pattern specification process response to heat response to abiotic stimulus response to temperature stimulus positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth P]	IPR004827	Basic-leucine zipper domain	Domain
C [auth P]	IPR008917	Transcription factor, Skn-1-like, DNA-binding domain superfamily	Homologous Superfamily
C [auth P]	IPR004826	Basic leucine zipper domain, Maf-type	Domain
C [auth P]	IPR047167	Nuclear Factor Erythroid-derived 2-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.