Annotations: 1SHX

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1shxb_	All beta proteins	Cupredoxin-like	Cupredoxins	Ephrin ectodomain	Ephrin-a5	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1shxa_	All beta proteins	Cupredoxin-like	Cupredoxins	Ephrin ectodomain	Ephrin-a5	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Cupredoxins	8032406	3000886	SCOP2B (2022-06-29)
A	SCOP2 Family	Ephrin ectodomain	8020026	4002092	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cupredoxins	8032406	3000886	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00812	e1shxB1	A: beta sandwiches	X: Cupredoxin-like	H: Cupredoxin-related (From Topology)	T: Cupredoxin-related	F: PF00812	ECOD (1.6)
A	PF00812	e1shxA1	A: beta sandwiches	X: Cupredoxin-like	H: Cupredoxin-related (From Topology)	T: Cupredoxin-related	F: PF00812	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.60.40.420	Mainly Beta	Sandwich	Immunoglobulin-like	Cupredoxins - blue copper proteins	CATH (4.3.0)
A	2.60.40.420	Mainly Beta	Sandwich	Immunoglobulin-like	Cupredoxins - blue copper proteins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00812	Ephrin (Ephrin)	Ephrin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Ephrin-A5	protein binding binding signaling receptor binding ephrin receptor binding neurotrophin TRK receptor binding neurotrophin TRKB receptor binding cytokine receptor binding neurotrophin receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity chemorepellent activity receptor ligand activity signaling receptor activator activity	regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion regulation of cellular process regulation of cellular component organization cell-substrate junction assembly cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly regulation of biological process regulation of cell-substrate adhesion regulation of cell adhesion biological regulation cell-substrate adhesion regulation of cellular component biogenesis regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization cellular process regulation of focal adhesion assembly regulation of cell-substrate junction assembly positive regulation of nervous system development multicellular organismal process positive regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process multicellular organism development anatomical structure development regulation of multicellular organismal process regulation of synapse structure or activity synapse organization regulation of synapse assembly regulation of biological quality positive regulation of cellular process system development developmental process regulation of multicellular organismal development positive regulation of cellular component biogenesis nervous system development positive regulation of cell junction assembly regulation of synapse organization positive regulation of multicellular organismal process synapse assembly positive regulation of synapse assembly cell-cell adhesion synaptic membrane adhesion cell-cell adhesion via plasma-membrane adhesion molecules axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation plasma membrane bounded cell projection organization axon guidance axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development retinal ganglion cell axon guidance regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway regulation of cell morphogenesis regulation of anatomical structure morphogenesis regulation of substrate adhesion-dependent cell spreading negative regulation of biological process negative regulation of cell adhesion negative regulation of substrate adhesion-dependent cell spreading negative regulation of cellular process substrate adhesion-dependent cell spreading negative regulation of cell-substrate adhesion regulation of cell-cell adhesion protein localization regulation of localization establishment of protein localization response to organic substance nitrogen compound transport localization carbohydrate homeostasis cellular macromolecule localization establishment of localization in cell regulation of peptide hormone secretion regulation of hormone levels organic substance transport establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion establishment of localization cellular response to oxygen-containing compound regulation of protein secretion regulation of secretion cellular response to carbohydrate stimulus chemical homeostasis response to glucose response to chemical glucose homeostasis insulin secretion involved in cellular response to glucose stimulus cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport homeostatic process hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance regulation of signaling secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell response to oxygen-containing compound cellular response to glucose stimulus regulation of protein transport peptide transport response to hexose cellular response to chemical stimulus cellular homeostasis protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport regulation of cell communication insulin secretion microtubule cytoskeleton organization regulation of microtubule-based process microtubule-based process regulation of microtubule cytoskeleton organization developmental growth cell growth collateral sprouting developmental cell growth growth developmental growth involved in morphogenesis cellular response to gonadotropin stimulus response to endogenous stimulus response to gonadotropin cellular response to endogenous stimulus response to hormone cellular response to follicle-stimulating hormone stimulus response to follicle-stimulating hormone cellular response to hormone stimulus regulation of growth regulation of cellular component size regulation of cell differentiation regulation of neurogenesis regulation of cell development positive regulation of cell projection organization positive regulation of developmental growth positive regulation of collateral sprouting regulation of cell projection organization positive regulation of cell development regulation of neuron projection development regulation of collateral sprouting regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis positive regulation of axonogenesis regulation of cell size regulation of developmental growth positive regulation of cell growth regulation of cell growth positive regulation of growth regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size regulation of molecular function regulation of catalytic activity regulation of hydrolase activity regulation of GTPase activity response to ketone response to lipid response to alcohol cellular response to forskolin cellular response to organic cyclic compound cellular response to alcohol response to forskolin cellular response to lipid cellular response to ketone response to organic cyclic compound regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process organic substance metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process regulation of peptidyl-tyrosine phosphorylation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process peptidyl-tyrosine phosphorylation regulation of metabolic process	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane basement membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix membrane microdomain membrane raft plasma membrane raft cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane basement membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola GABA-ergic synapse synapse cell junction cell-cell junction adherens junction anchoring junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR019765	Ephrin, conserved site	Conserved Site
A, B	IPR008972	Cupredoxin	Homologous Superfamily
A, B	IPR031328	Ephrin	Family
A, B	IPR034252	Ephrin-A ectodomain	Domain
A, B	IPR001799	Ephrin receptor-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.