1SGH

Moesin FERM domain bound to EBP50 C-terminal peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1sgha1	All alpha proteins	Acyl-CoA binding protein-like	Second domain of FERM	Second domain of FERM	Moesin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1sgha2	All beta proteins	PH domain-like barrel	PH domain-like	Third domain of FERM	Moesin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1sgha3	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	First domain of FERM	Moesin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1sghb_	Peptides	Ezrin-radixin-moesin binding phosphoprotein 50 (ebp50) fragments	Ezrin-radixin-moesin binding phosphoprotein 50 (ebp50) fragments	Ezrin-radixin-moesin binding phosphoprotein 50 (ebp50) fragments	Ezrin-radixin-moesin binding phosphoprotein 50 (ebp50) fragments	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	FERM central domain-like	8036735	3001227	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ubiquitin-like	8034471	3000157	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PH domain-like	8042506	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FERM_C	e1sghA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: FERM_C	ECOD (1.6)
A	FERM_M	e1sghA2	A: alpha bundles	X: Acyl-CoA binding protein-like (From Topology)	H: Acyl-CoA binding protein-like (From Topology)	T: Acyl-CoA binding protein-like	F: FERM_M	ECOD (1.6)
A	FERM_N	e1sghA3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: FERM_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
A	1.20.80.10	Mainly Alpha	Up-down Bundle	Acyl-CoA Binding Protein		CATH (4.3.0)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09379	FERM N-terminal domain (FERM_N)	FERM N-terminal domain	This domain is the N-terminal ubiquitin-like structural domain of the FERM domain.	Domain
A	PF09380	FERM C-terminal PH-like domain (FERM_C)	FERM C-terminal PH-like domain	-	Domain
A	PF00373	FERM central domain (FERM_M)	FERM central domain	This domain is the central structural domain of the FERM domain.	Domain
B	PF09007	EBP50, C-terminal (EBP50_C)	EBP50, C-terminal	This C terminal domain allows interaction of EBP50 with FERM (four-point one ERM) domains, resulting in the activation of Ezrin-radixin-moesin (ERM), with subsequent cytoskeletal modulation and cellular growth control [1]. It includes a disordered se ...	This C terminal domain allows interaction of EBP50 with FERM (four-point one ERM) domains, resulting in the activation of Ezrin-radixin-moesin (ERM), with subsequent cytoskeletal modulation and cellular growth control [1]. It includes a disordered section between two reasonably well conserved hydrophobic regions.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Moesin	RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding protein binding signaling receptor binding cell adhesion molecule binding kinase binding enzyme binding protein kinase binding cytoskeletal protein binding actin binding structural constituent of cytoskeleton RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding protein binding signaling receptor binding cell adhesion molecule binding kinase binding enzyme binding protein kinase binding cytoskeletal protein binding actin binding structural constituent of cytoskeleton structural molecule activity	membrane to membrane docking cellular process membrane docking regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process membrane to membrane docking cellular process membrane docking regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cellular component organization regulation of cellular component size cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size leukocyte migration immune system process mononuclear cell migration lymphocyte migration cell migration T cell migration cell motility regulation of cellular component organization organelle assembly regulation of cellular component biogenesis regulation of organelle organization cellular component biogenesis organelle organization cellular component assembly regulation of organelle assembly multicellular organismal process cell population proliferation cell activation lymphocyte activation leukocyte proliferation leukocyte activation mononuclear cell proliferation T cell activation lymphocyte proliferation T cell proliferation developmental process anatomical structure morphogenesis gland morphogenesis gland development animal organ development anatomical structure development animal organ morphogenesis T cell aggregation cell adhesion cell-cell adhesion lymphocyte aggregation leukocyte cell-cell adhesion leukocyte aggregation positive regulation of organelle organization positive regulation of cellular component organization non-membrane-bounded organelle assembly positive regulation of podosome assembly positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly regulation of podosome assembly protein-containing complex assembly podosome assembly positive regulation of cellular component biogenesis protein-containing complex organization positive regulation of organelle assembly catabolic process positive regulation of protein metabolic process macromolecule catabolic process regulation of primary metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process primary metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process organic substance catabolic process regulation of protein catabolic process polarized epithelial cell differentiation establishment of monopolar cell polarity establishment or maintenance of monopolar cell polarity cellular developmental process establishment or maintenance of cell polarity epithelial cell differentiation morphogenesis of a polarized epithelium cell differentiation establishment or maintenance of apical/basal cell polarity establishment or maintenance of bipolar cell polarity epithelium development establishment of epithelial cell apical/basal polarity morphogenesis of an epithelium tissue development establishment of cell polarity tissue morphogenesis establishment or maintenance of epithelial cell apical/basal polarity establishment of apical/basal cell polarity establishment of epithelial cell polarity protein localization regulation of localization cellular localization positive regulation of protein localization to early endosome regulation of protein localization protein localization to endosome protein localization to early endosome localization regulation of protein localization to endosome regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization positive regulation of protein localization to endosome regulation of protein localization to early endosome regulation of developmental process regulation of cell shape cell morphogenesis regulation of cell morphogenesis regulation of anatomical structure morphogenesis endothelial cell differentiation endothelium development cell development endothelial cell development epithelial cell development establishment of endothelial barrier cellular response to testosterone stimulus cellular response to stimulus response to organic substance response to ketone response to stimulus response to lipid cellular response to organic cyclic compound response to oxygen-containing compound cellular response to oxygen-containing compound response to testosterone cellular response to chemical stimulus response to chemical cellular response to lipid cellular response to organic substance cellular response to ketone response to organic cyclic compound immunological synapse formation cell-cell recognition cell recognition positive regulation of early endosome to late endosome transport transport vesicle-mediated transport establishment of localization in cell positive regulation of intracellular transport regulation of intracellular transport regulation of transport intracellular transport regulation of vesicle-mediated transport establishment of localization endosomal transport vesicle-mediated transport between endosomal compartments regulation of early endosome to late endosome transport early endosome to late endosome transport positive regulation of transport regulation of cell motility regulation of leukocyte migration regulation of lymphocyte migration regulation of locomotion regulation of cell migration regulation of immune system process regulation of mononuclear cell migration locomotion	cell projection pseudopodium cellular anatomical entity plasma membrane bounded cell projection apical part of cell extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell projection pseudopodium cellular anatomical entity plasma membrane bounded cell projection apical part of cell extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane plasma membrane cell periphery actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane basal part of cell basal plasma membrane basolateral plasma membrane cell-cell junction adherens junction anchoring junction cell junction intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle perinuclear region of cytoplasm filopodium focal adhesion cell-substrate junction apical plasma membrane cell surface blood microparticle uropod cell trailing edge nucleus intracellular membrane-bounded organelle
B	Ezrin-radixin-moesin binding phosphoprotein 50	beta-2 adrenergic receptor binding protein binding binding adrenergic receptor binding signaling receptor binding G protein-coupled receptor binding cytoskeletal protein binding myosin II binding myosin binding type 2 metabotropic glutamate receptor binding glutamate receptor binding G protein-coupled glutamate receptor binding protein-containing complex binding channel regulator activity beta-2 adrenergic receptor binding protein binding binding adrenergic receptor binding signaling receptor binding G protein-coupled receptor binding cytoskeletal protein binding myosin II binding myosin binding type 2 metabotropic glutamate receptor binding glutamate receptor binding G protein-coupled glutamate receptor binding protein-containing complex binding channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity chloride channel regulator activity amino acid transmembrane transporter activity gamma-aminobutyric acid transmembrane transporter activity transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity phosphatase binding enzyme binding identical protein binding PDZ domain binding protein domain specific binding growth factor receptor binding type 3 metabotropic glutamate receptor binding dopamine receptor binding transmembrane transporter binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity transporter activator activity molecular function activator activity channel activator activity beta-catenin binding	multicellular organismal process inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation inner ear development anatomical structure development multicellular organismal process inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation inner ear development anatomical structure development animal organ morphogenesis system development developmental process embryonic organ morphogenesis mechanoreceptor differentiation epithelium development epidermal cell differentiation ear development embryonic morphogenesis nervous system development tissue development inner ear receptor cell differentiation generation of neurons auditory receptor cell development cellular developmental process cell development embryo development cell morphogenesis cellular component organization neurogenesis cellular component organization or biogenesis auditory receptor cell morphogenesis embryonic organ development ear morphogenesis plasma membrane bounded cell projection organization animal organ development inner ear auditory receptor cell differentiation cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis sensory organ morphogenesis neuron development inner ear morphogenesis cellular process inner ear receptor cell stereocilium organization cellular response to stimulus regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction regulation of platelet-derived growth factor receptor signaling pathway negative regulation of cell communication cell surface receptor protein tyrosine kinase signaling pathway cell communication negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling regulation of biological process cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of platelet-derived growth factor receptor signaling pathway biological regulation platelet-derived growth factor receptor signaling pathway negative regulation of signal transduction regulation of response to stimulus regulation of cell communication renal system process system process transport renal sodium ion transport establishment of localization metal ion transport localization monoatomic ion transport monoatomic cation transport sodium ion transport membrane organization plasma membrane organization endomembrane system organization tissue morphogenesis morphogenesis of an epithelium regulation of cellular component size regulation of biological quality regulation of cell size regulation of anatomical structure size regulation of localization regulation of transport regulation of monoatomic ion transport monoatomic ion transmembrane transport positive regulation of biological process regulation of monoatomic ion transmembrane transport transmembrane transport regulation of transmembrane transport positive regulation of transport positive regulation of monoatomic ion transport positive regulation of transmembrane transport positive regulation of monoatomic ion transmembrane transport positive regulation of cellular process establishment of organelle localization cellular localization nucleus localization intracellular transport organelle localization establishment of localization in cell nuclear migration regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of Wnt signaling pathway Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway protein localization protein localization to cell periphery protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane negative regulation of intracellular signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette regulation of MAPK cascade negative regulation of ERK1 and ERK2 cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity maintenance of cell polarity maintenance of epithelial cell apical/basal polarity maintenance of apical/basal cell polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity ameboidal-type cell migration cell migration fibroblast migration cell motility negative regulation of monoatomic ion transport negative regulation of transport regulation of sodium ion transport negative regulation of sodium ion transport regulation of metal ion transport organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization bile acid secretion organic anion transport carboxylic acid transport secretion organic substance transport acid secretion organic acid transport monocarboxylic acid transport plasma membrane bounded cell projection assembly microvillus organization cellular component biogenesis cellular component assembly microvillus assembly cell projection assembly nervous system process epithelial cilium movement involved in extracellular fluid movement extracellular transport microtubule-based transport microtubule-based movement microtubule-based process cerebrospinal fluid circulation cilium movement renal absorption regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction sensory perception sensory perception of sound sensory perception of mechanical stimulus gland morphogenesis gland development positive regulation of cell communication positive regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus intrinsic apoptotic signaling pathway positive regulation of programmed cell death regulation of apoptotic process positive regulation of intracellular signal transduction cell death positive regulation of apoptotic process apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling nitrogen compound transport gamma-aminobutyric acid import amino acid transport acidic amino acid transport gamma-aminobutyric acid transport cellular response to nitrogen compound response to dopamine response to organic substance dopamine receptor signaling pathway cellular response to dopamine response to monoamine cellular response to endogenous stimulus response to catecholamine adenylate cyclase-activating dopamine receptor signaling pathway cellular response to catecholamine stimulus cellular response to organic substance response to organic cyclic compound response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound adenylate cyclase-activating G protein-coupled receptor signaling pathway cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound cellular response to monoamine stimulus response to chemical adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway circulatory system process vascular process in circulatory system vascular transport transport across blood-brain barrier regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of transferase activity regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process organonitrogen compound metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function regulation of kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of locomotion regulation of cell motility regulation of fibroblast migration negative regulation of fibroblast migration regulation of locomotion regulation of cell migration negative regulation of cell motility negative regulation of cell migration locomotion phospholipase C-activating dopamine receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway Golgi localization establishment of Golgi localization phosphate ion homeostasis intracellular phosphate ion homeostasis cellular homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis protein-containing complex organization protein-containing complex assembly import into cell import across plasma membrane polarized epithelial cell differentiation establishment of monopolar cell polarity establishment or maintenance of monopolar cell polarity morphogenesis of a polarized epithelium establishment of epithelial cell apical/basal polarity establishment of cell polarity establishment of apical/basal cell polarity establishment of epithelial cell polarity excretion regulation of renal system process regulation of system process renal tubular secretion regulation of secretion regulation of renal phosphate excretion renal phosphate excretion regulation of multicellular organismal process regulation of excretion renal phosphate ion absorption regulation of developmental process regulation of cell shape regulation of cell morphogenesis regulation of anatomical structure morphogenesis negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation oligopeptide transport glutathione transport tripeptide transport amide transport sulfur compound transport modified amino acid transport cilium organization negative regulation of cell cycle negative regulation of mitotic cell cycle mitotic cell cycle regulation of mitotic cell cycle cell cycle regulation of cell cycle	membrane cellular anatomical entity cell projection stereocilium actin-based cell projection organelle stereocilium tip stereocilium bundle neuron projection cluster of actin-based cell projections plasma membrane bounded cell projection extracellular exosome membrane-bounded organelle extracellular vesicle membrane cellular anatomical entity cell projection stereocilium actin-based cell projection organelle stereocilium tip stereocilium bundle neuron projection cluster of actin-based cell projections plasma membrane bounded cell projection extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle plasma membrane cell periphery plasma membrane region microvillus microvillus membrane cell projection membrane sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium cytoplasm protein-containing complex plasma membrane protein complex membrane protein complex ruffle cell leading edge perinuclear region of cytoplasm filopodium endomembrane system apical part of cell apical plasma membrane brush border membrane brush border

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000299	FERM domain	Domain
A	IPR019748	FERM central domain	Domain
A	IPR018980	FERM, C-terminal PH-like domain	Domain
A	IPR000798	Ezrin/radixin/moesin-like	Family
A	IPR008954	Moesin tail domain superfamily	Homologous Superfamily
A	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A	IPR011259	Ezrin/radixin/moesin, C-terminal	Domain
A	IPR019747	FERM conserved site	Conserved Site
A	IPR018979	FERM, N-terminal	Domain
A	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A	IPR041789	ERM family, FERM domain C-lobe	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR046810	Ezrin/radixin/moesin, alpha-helical domain	Domain
A	IPR019749	Band 4.1 domain	Domain
A	IPR011174	Ezrin/radixin/moesin	Family
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B	IPR017300	Na(+)/H(+) exchange regulatory cofactor NHERF-1/2	Family
B	IPR015098	EBP50, C-terminal	Domain
B	IPR036034	PDZ superfamily	Homologous Superfamily
B	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P26038	combined immunodeficiency due to moesin deficiency juvenile idiopathic arthritis Liver Cirrhosis, Experimental lung cancer malignant ependymoma medulloblastoma osteoarthritis astrocytic tumor ovarian cancer pilocytic astrocytoma Down syndrome primitive neuroectodermal tumor exocrine pancreatic carcinoma glioblastoma juvenile dermatomyositis combined immunodeficiency due to moesin deficiency juvenile idiopathic arthritis Liver Cirrhosis, Experimental lung cancer malignant ependymoma medulloblastoma osteoarthritis astrocytic tumor ovarian cancer pilocytic astrocytoma Down syndrome primitive neuroectodermal tumor exocrine pancreatic carcinoma glioblastoma juvenile dermatomyositis lung carcinoma malignant glioma myocardial ischemia osteoarthritis susceptibility 1 Becker muscular dystrophy pancreatic ductal adenocarcinoma coronary artery disease pituitary cancer subependymal giant cell astrocytoma Duchenne muscular dystrophy gastric cancer interstitial cystitis lymphoplasmacytic lymphoma malignant pancreatic neoplasm myopathy breast cancer pancreatic intraductal papillary-mucinous carcinoma dermatomyositis plasma cell myeloma ulcerative colitis Emery-Dreifuss muscular dystrophy gastric carcinoma
B	Pharos: O14745	hypophosphatemic nephrolithiasis/osteoporosis 2 invasive ductal breast carcinoma adrenal cortex carcinoma ductal breast carcinoma in situ Mammary Ductal Carcinoma osteosarcoma atypical teratoid rhabdoid tumor medulloblastoma ovarian cancer breast carcinoma non-small cell lung carcinoma ulcerative colitis