1S40

SOLUTION STRUCTURE OF THE CDC13 DNA-BINDING DOMAIN COMPLEXED WITH A SINGLE-STRANDED TELOMERIC DNA 11-MER

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d1s40a_	All beta proteins	OB-fold	Nucleic acid-binding proteins	Single strand DNA-binding domain, SSB	CDC13 ssDNA-binding domain	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2 Family	Single strand DNA-binding domain SSB	8028944	4000346	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	Nucleic acid-binding proteins	8041323	3000135	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	POT1	e1s40A1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: POT1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A]	PF02765	Telomeric single stranded DNA binding POT1/CDC13 (POT1)	Telomeric single stranded DNA binding POT1/CDC13	This domain binds single stranded telomeric DNA and adopts an OB fold [1]. It includes the proteins POT1 and CDC13 which have been shown to regulate telomere length, replication and capping [2-4]. POT1 is one component of the shelterin complex that ...	This domain binds single stranded telomeric DNA and adopts an OB fold [1]. It includes the proteins POT1 and CDC13 which have been shown to regulate telomere length, replication and capping [2-4]. POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms [5,6].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	5'-D(GPTPGPTPGPGPGPTPGPTP*G)-3'	-	-	-
B [auth A]	Cell division control protein 13	sequence-specific DNA binding DNA binding G-rich strand telomeric DNA binding binding organic cyclic compound binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding nucleic acid binding telomeric DNA binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity sequence-specific DNA binding DNA binding G-rich strand telomeric DNA binding binding organic cyclic compound binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding nucleic acid binding telomeric DNA binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity telomerase inhibitor activity protein binding translation elongation factor binding identical protein binding	cellular process cell cycle cellular biosynthetic process telomere organization RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening cellular component organization nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis telomere maintenance via telomerase cellular metabolic process cellular process cell cycle cellular biosynthetic process telomere organization RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening cellular component organization nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis telomere maintenance via telomerase cellular metabolic process chromosome organization primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process telomere maintenance organic cyclic compound metabolic process organelle organization biosynthetic process organic cyclic compound biosynthetic process metabolic process macromolecule metabolic process DNA biosynthetic process regulation of telomere maintenance regulation of cellular component organization regulation of cellular process regulation of DNA biosynthetic process regulation of primary metabolic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of chromosome organization regulation of macromolecule metabolic process regulation of telomere maintenance via telomere lengthening regulation of organelle organization regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process regulation of DNA metabolic process localization cellular localization ribonucleoprotein complex localization cell division telomere capping	membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus nuclear protein-containing complex chromosome cellular anatomical entity intracellular membrane-bounded organelle chromosomal region intracellular organelle organelle telomere cap complex intracellular non-membrane-bounded organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus nuclear protein-containing complex chromosome cellular anatomical entity intracellular membrane-bounded organelle chromosomal region intracellular organelle organelle telomere cap complex intracellular non-membrane-bounded organelle chromosome, telomeric repeat region CST complex chromosome, telomeric region non-membrane-bounded organelle nuclear telomere cap complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth A]	IPR031749	Cell division control protein 13, N-terminal	Domain
B [auth A]	IPR011564	Telomeric single stranded DNA binding POT1/Cdc13	Domain
B [auth A]	IPR028389	Protection of telomeres protein 1	Family
B [auth A]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B [auth A]	IPR041028	Cdc13, OB4 dimerization domain	Domain
B [auth A]	IPR040650	Cell division control protein 13, OB2 domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.