1RZX

Crystal Structure of a Par-6 PDZ-peptide Complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1rzxa_	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	GTPase-binding domain of the cell polarity protein par6 (Par-6B)	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PDZ domain	8028767	4001790	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PDZ domain-like	8041146	3000388	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e1rzxA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CG5884-PA	enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity	developmental process neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process neuroblast division nervous system development asymmetric cell division generation of neurons neurogenesis multicellular organism development asymmetric neuroblast division cell differentiation anatomical structure development developmental process neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process neuroblast division nervous system development asymmetric cell division generation of neurons neurogenesis multicellular organism development asymmetric neuroblast division cell differentiation anatomical structure development cellular process cell division neural precursor cell proliferation cell fate commitment system development protein localization localization cellular localization apical protein localization cellular macromolecule localization macromolecule localization epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis branching involved in open tracheal system development tube morphogenesis terminal branching, open tracheal system morphogenesis of a branching structure respiratory system development epithelial tube morphogenesis open tracheal system development morphogenesis of a branching epithelium adherens junction organization adherens junction assembly apical junction assembly cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cellular component organization or biogenesis zonula adherens assembly cell-cell junction assembly cell-cell junction organization establishment or maintenance of cell polarity establishment or maintenance of neuroblast polarity cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of smoothened signaling pathway signal transduction positive regulation of cellular process regulation of smoothened signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation smoothened signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling establishment of neuroblast polarity establishment of cell polarity morphogenesis of embryonic epithelium embryonic morphogenesis embryo development establishment or maintenance of polarity of embryonic epithelium morphogenesis of a polarized epithelium microtubule organizing center organization microtubule cytoskeleton organization organelle organization centrosome cycle microtubule-based process cell cycle cytoskeleton organization cell cycle process filopodium assembly regulation of cellular component organization positive regulation of cellular component organization cell projection organization regulation of filopodium assembly plasma membrane bounded cell projection assembly positive regulation of cell projection organization positive regulation of filopodium assembly plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly synapse organization synapse assembly sexual reproduction reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction female gamete generation epithelial cell differentiation gamete generation follicle cell of egg chamber development tissue migration ameboidal-type cell migration epithelial cell migration cell migration cell motility oogenesis multicellular organismal reproductive process follicle cell of egg chamber migration epithelium migration epithelial cell development border follicle cell migration germ cell development regulation of lamellipodium assembly regulation of lamellipodium organization lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of lamellipodium organization lamellipodium organization establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity	cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane axon synapse neuron projection axon terminus cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane axon synapse neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton cell junction neuron projection terminus cell-cell junction protein-containing complex plasma membrane protein complex anchoring junction membrane protein complex apical junction complex subapical complex muscle cell postsynaptic specialization postsynapse neuromuscular junction postsynaptic specialization organelle postsynapse of neuromuscular junction bicellular tight junction tight junction cell cortex region cytoplasmic region apical cortex
B	Acetylated VKESLV Peptide	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000270	PB1 domain	Domain
A	IPR034868	Partitioning defective protein 6, PB1 domain	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.