1RZ0

Flavin reductase PheA2 in native state

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1rz0b_	All beta proteins	Split barrel-like	FMN-binding split barrel	NADH:FMN oxidoreductase-like	Phenol 2-hydroxylase component B (PheA2)	(Parageobacillus thermoglucosidasius ) [TaxId: 1426 ],	SCOPe (2.08)
C	d1rz0c_	All beta proteins	Split barrel-like	FMN-binding split barrel	NADH:FMN oxidoreductase-like	Phenol 2-hydroxylase component B (PheA2)	(Parageobacillus thermoglucosidasius ) [TaxId: 1426 ],	SCOPe (2.08)
D	d1rz0d_	All beta proteins	Split barrel-like	FMN-binding split barrel	NADH:FMN oxidoreductase-like	Phenol 2-hydroxylase component B (PheA2)	(Parageobacillus thermoglucosidasius ) [TaxId: 1426 ],	SCOPe (2.08)
E	d1rz0e_	All beta proteins	Split barrel-like	FMN-binding split barrel	NADH:FMN oxidoreductase-like	Phenol 2-hydroxylase component B (PheA2)	(Parageobacillus thermoglucosidasius ) [TaxId: 1426 ],	SCOPe (2.08)
F	d1rz0f_	All beta proteins	Split barrel-like	FMN-binding split barrel	NADH:FMN oxidoreductase-like	Phenol 2-hydroxylase component B (PheA2)	(Parageobacillus thermoglucosidasius ) [TaxId: 1426 ],	SCOPe (2.08)
G	d1rz0g_	All beta proteins	Split barrel-like	FMN-binding split barrel	NADH:FMN oxidoreductase-like	Phenol 2-hydroxylase component B (PheA2)	(Parageobacillus thermoglucosidasius ) [TaxId: 1426 ],	SCOPe (2.08)
H	d1rz0h_	All beta proteins	Split barrel-like	FMN-binding split barrel	NADH:FMN oxidoreductase-like	Phenol 2-hydroxylase component B (PheA2)	(Parageobacillus thermoglucosidasius ) [TaxId: 1426 ],	SCOPe (2.08)
A	d1rz0a_	All beta proteins	Split barrel-like	FMN-binding split barrel	NADH:FMN oxidoreductase-like	Phenol 2-hydroxylase component B (PheA2)	(Parageobacillus thermoglucosidasius ) [TaxId: 1426 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	FMN-binding split barrel	8041072	3000856	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	FMN-binding split barrel	8041072	3000856	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	FMN-binding split barrel	8041072	3000856	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	FMN-binding split barrel	8041072	3000856	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	FMN-binding split barrel	8041072	3000856	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	FMN-binding split barrel	8041072	3000856	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	FMN-binding split barrel	8041072	3000856	SCOP2B (2022-06-29)
A	SCOP2 Family	NADH:FMN oxidoreductase-like	8028693	4002136	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	FMN-binding split barrel	8041072	3000856	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF01613	e1rz0B1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: PF01613	ECOD (1.6)
C	PF01613	e1rz0C1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: PF01613	ECOD (1.6)
D	PF01613	e1rz0D1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: PF01613	ECOD (1.6)
E	PF01613	e1rz0E1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: PF01613	ECOD (1.6)
F	PF01613	e1rz0F1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: PF01613	ECOD (1.6)
G	PF01613	e1rz0G1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: PF01613	ECOD (1.6)
H	PF01613	e1rz0H1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: PF01613	ECOD (1.6)
A	PF01613	e1rz0A1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: PF01613	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.30.110.10	Mainly Beta	Roll	Pnp Oxidase	Chain A	CATH (4.3.0)
C	2.30.110.10	Mainly Beta	Roll	Pnp Oxidase	Chain A	CATH (4.3.0)
D	2.30.110.10	Mainly Beta	Roll	Pnp Oxidase	Chain A	CATH (4.3.0)
E	2.30.110.10	Mainly Beta	Roll	Pnp Oxidase	Chain A	CATH (4.3.0)
F	2.30.110.10	Mainly Beta	Roll	Pnp Oxidase	Chain A	CATH (4.3.0)
G	2.30.110.10	Mainly Beta	Roll	Pnp Oxidase	Chain A	CATH (4.3.0)
H	2.30.110.10	Mainly Beta	Roll	Pnp Oxidase	Chain A	CATH (4.3.0)
A	2.30.110.10	Mainly Beta	Roll	Pnp Oxidase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF01613	Flavin reductase like domain (Flavin_Reduct)	Flavin reductase like domain	This is a flavin reductase family consisting of enzymes known to be flavin reductases as well as various oxidoreductase and monooxygenase components. VlmR is a flavin reductase that functions in a two-component enzyme system to provide isobutylamine ...	This is a flavin reductase family consisting of enzymes known to be flavin reductases as well as various oxidoreductase and monooxygenase components. VlmR is a flavin reductase that functions in a two-component enzyme system to provide isobutylamine N-hydroxylase with reduced flavin and may be involved in the synthesis of valanimycin [1]. SnaC is a flavin reductase that provides reduced flavin for the oxidation of pristinamycin IIB to pristinamycin IIA as catalysed by SnaA, SnaB heterodimer [2]. This flavin reductase region characterised by enzymes of the family is present in the C-terminus of potential FMN proteins from Synechocystis sp. suggesting it is a flavin reductase domain [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	phenol 2-hydroxylase component B	binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-NH group of donors binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-NH group of donors catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR012349	FMN-binding split barrel	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR002563	Flavin reductase like domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.